Transcription Factor Sp1 in the Expression of Genes Encoding Components of Mapk, JAK/STAT, and PI3K/Akt Signaling Pathways

Sp1 is a transcription factor of the Sp/KLF family that binds to GC-rich motifs in regulatory regions of genes. Sp1 is involved in the regulation of cell proliferation, apoptosis and differentiation, and angiogenesis. A high level of SP1 expression, as well as its aberrant transcriptional activity d...

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Published in	Molecular biology (New York) Vol. 56; no. 5; pp. 756 - 769
Main Authors	Ivanenko, K. A., Prassolov, V. S., Khabusheva, E. R.
Format	Journal Article
Language	English
Published	Moscow Pleiades Publishing 01.10.2022 Springer Nature B.V
Subjects	1-Phosphatidylinositol 3-kinase AKT protein Amino acids Angiogenesis Apoptosis Biochemistry Biomedical and Life Sciences Breast cancer Cell death Cell differentiation Cell growth Cell proliferation Cofactors Coronary artery disease Gastric cancer Glioma Heart diseases Human Genetics Life Sciences Lung diseases MAP kinase Neurodegenerative diseases Pancreatic cancer Phosphorylation Post-translation Regulatory sequences Reviews Signal transduction Thyroid cancer Transcription factors transcription factor Sp1 signaling pathways malignant diseases
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Abstract	Sp1 is a transcription factor of the Sp/KLF family that binds to GC-rich motifs in regulatory regions of genes. Sp1 is involved in the regulation of cell proliferation, apoptosis and differentiation, and angiogenesis. A high level of SP1 expression, as well as its aberrant transcriptional activity due to post-translational modifications, is found in cells in oncological diseases, such as lung, breast, pancreatic, thyroid, gastric cancer, and glioma; congenital heart disease, as well as neurodegenerative disorders, including Huntington’s and Parkinson’s diseases. Binding of Sp1 to GC-rich motifs of the regulatory regions of the genes encoding components of the MAPK, p38, JAK/STAT, PI3K/Akt signaling pathways, is involved in the control of cell proliferation, differentiation, and death. In addition, kinases of these signaling pathways are able to change the transcriptional activity of Sp1 by phosphorylation of certain amino acid residues, which leads to a change in the efficiency of its binding to cofactors and DNA regulatory regions. This review presents data on the relationship between the Sp1 transcription factor and the activity of the MAPK, p38, JAK/STAT, and PI3K/Akt signaling pathways in normal tissues and in various pathologies, including malignant diseases.
AbstractList	Sp1 is a transcription factor of the Sp/KLF family that binds to GC-rich motifs in regulatory regions of genes. Sp1 is involved in the regulation of cell proliferation, apoptosis and differentiation, and angiogenesis. A high level of SP1 expression, as well as its aberrant transcriptional activity due to post-translational modifications, is found in cells in oncological diseases, such as lung, breast, pancreatic, thyroid, gastric cancer, and glioma; congenital heart disease, as well as neurodegenerative disorders, including Huntington’s and Parkinson’s diseases. Binding of Sp1 to GC-rich motifs of the regulatory regions of the genes encoding components of the MAPK, p38, JAK/STAT, PI3K/Akt signaling pathways, is involved in the control of cell proliferation, differentiation, and death. In addition, kinases of these signaling pathways are able to change the transcriptional activity of Sp1 by phosphorylation of certain amino acid residues, which leads to a change in the efficiency of its binding to cofactors and DNA regulatory regions. This review presents data on the relationship between the Sp1 transcription factor and the activity of the MAPK, p38, JAK/STAT, and PI3K/Akt signaling pathways in normal tissues and in various pathologies, including malignant diseases. Sp1 is a transcription factor of the Sp/KLF family that binds to GC-rich motifs in regulatory regions of genes. Sp1 is involved in the regulation of cell proliferation, apoptosis and differentiation, and angiogenesis. A high level of SP1 expression, as well as its aberrant transcriptional activity due to post-translational modifications, is found in cells in oncological diseases, such as lung, breast, pancreatic, thyroid, gastric cancer, and glioma; congenital heart disease, as well as neurodegenerative disorders, including Huntington’s and Parkinson’s diseases. Binding of Sp1 to GC-rich motifs of the regulatory regions of the genes encoding components of the MAPK, p38, JAK/STAT, PI3K/Akt signaling pathways, is involved in the control of cell proliferation, differentiation, and death. In addition, kinases of these signaling pathways are able to change the transcriptional activity of Sp1 by phosphorylation of certain amino acid residues, which leads to a change in the efficiency of its binding to cofactors and DNA regulatory regions. This review presents data on the relationship between the Sp1 transcription factor and the activity of the MAPK, p38, JAK/STAT, and PI3K/Akt signaling pathways in normal tissues and in various pathologies, including malignant diseases.
Author	Khabusheva, E. R. Prassolov, V. S. Ivanenko, K. A.
Author_xml	– sequence: 1 givenname: K. A. surname: Ivanenko fullname: Ivanenko, K. A. organization: Engelhardt Institute of Molecular Biology, Russian Academy of Sciences – sequence: 2 givenname: V. S. surname: Prassolov fullname: Prassolov, V. S. organization: Engelhardt Institute of Molecular Biology, Russian Academy of Sciences – sequence: 3 givenname: E. R. surname: Khabusheva fullname: Khabusheva, E. R. email: vr.elmira@gmail.com organization: Engelhardt Institute of Molecular Biology, Russian Academy of Sciences
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CitedBy_id	crossref_primary_10_1016_j_advms_2023_10_007 crossref_primary_10_1093_neuonc_noae015 crossref_primary_10_1080_08820139_2022_2157283 crossref_primary_10_1016_j_bbagrm_2023_195003 crossref_primary_10_1007_s10528_023_10412_x
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Copyright	Pleiades Publishing, Inc. 2022. ISSN 0026-8933, Molecular Biology, 2022, Vol. 56, No. 5, pp. 756–769. © Pleiades Publishing, Inc., 2022. Russian Text © The Author(s), 2022, published in Molekulyarnaya Biologiya, 2022, Vol. 56, No. 5, pp. 832–847.
Copyright_xml	– notice: Pleiades Publishing, Inc. 2022. ISSN 0026-8933, Molecular Biology, 2022, Vol. 56, No. 5, pp. 756–769. © Pleiades Publishing, Inc., 2022. Russian Text © The Author(s), 2022, published in Molekulyarnaya Biologiya, 2022, Vol. 56, No. 5, pp. 832–847.
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Snippet	Sp1 is a transcription factor of the Sp/KLF family that binds to GC-rich motifs in regulatory regions of genes. Sp1 is involved in the regulation of cell...
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SubjectTerms	1-Phosphatidylinositol 3-kinase AKT protein Amino acids Angiogenesis Apoptosis Biochemistry Biomedical and Life Sciences Breast cancer Cell death Cell differentiation Cell growth Cell proliferation Cofactors Coronary artery disease Gastric cancer Glioma Heart diseases Human Genetics Life Sciences Lung diseases MAP kinase Neurodegenerative diseases Pancreatic cancer Phosphorylation Post-translation Regulatory sequences Reviews Signal transduction Thyroid cancer Transcription factors
Title	Transcription Factor Sp1 in the Expression of Genes Encoding Components of Mapk, JAK/STAT, and PI3K/Akt Signaling Pathways
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