Allergen-induced Increases in Sputum Levels of Group 2 Innate Lymphoid Cells in Subjects with Asthma

• Published in: American journal of respiratory and critical care medicine Vol. 196; no. 6; pp. 700 - 712
• Main Authors: Chen, Ruchong, Smith, Steven G., Salter, Brittany, El-Gammal, Amani, Oliveria, John Paul, Obminski, Caitlin, Watson, Rick, O’Byrne, Paul M., Gauvreau, Gail M., Sehmi, Roma
• Format: Journal Article
• Language: English
• Published: United States American Thoracic Society 15.09.2017
• Subjects: Allergens - immunology; Allergies; Asthma; Asthma - immunology; Asthma - physiopathology; Bone marrow; Cross-Over Studies; Cytokines; Eosinophils - immunology; Eosinophils - metabolism; Humans; Hypersensitivity, Immediate - physiopathology; Inflammation; Lymphocytes; Lymphocytes - immunology; Lymphocytes - metabolism; Sputum - immunology; Sputum - metabolism; allergic asthma; eosinophilic inflammation; innate lymphoid cells

Group 2 innate lymphoid cells (ILC2), a major source of type 2 cytokines, initiate eosinophilic inflammatory responses in murine models of asthma. To investigate the role of ILC2 in allergen-induced airway eosinophilic responses in subjects with atopy and asthma. Using a diluent-controlled allergen...