Expression heterogeneity, tumor immune characteristics and the prognosis effects of OPRL1 in patients with tumors: a pan-cancer study combined with bioinformation analyses and in vitro validation

• Published in: ANESTHESIOLOGY AND PERIOPERATIVE SCIENCE Vol. 2; no. 1; pp. 1 - 16
• Main Authors: Wang, Xiaoqiang, Tao, Yiying, Zhang, Chaojin, Tian, Jie, Yu, Weifeng
• Format: Journal Article
• Language: English
• Published: Singapore Springer Nature Singapore 23.01.2024; Springer
• Subjects: Anesthesiology; Cancer; Critical Care Medicine; Intensive; Medicine; Medicine & Public Health; Neurosciences; Opioid receptor; OPRL1; Original Research; Overall survival; Pharmacology/Toxicology; Surgery; TCGA; Tumor immune microenvironment; OPRL1; Tumor immune microenvironment; Overall survival; Opioid receptor; TCGA; Cancer

Purpose Opioids are currently the most frequently prescribed analgesics in clinical practice. However, their effect on cancer progression remains a topic of debate. Opioid receptors (ORs) are present in various types of tumor cells and their expression levels vary depending on the type of tumor. Thi...