SHANK2 protein contributes to sevoflurane-induced developmental neurotoxicity and cognitive dysfunction in C57BL/6 male mice

• Published in: ANESTHESIOLOGY AND PERIOPERATIVE SCIENCE Vol. 1; no. 1; pp. 1 - 15
• Main Authors: Song, Shaoyong, Zhao, Weiming, Ji, Yumeng, Huang, Qinghong, Li, Yixuan, Chen, Shiwen, Yang, Jianping, Jin, Xin
• Format: Journal Article
• Language: English
• Published: Singapore Springer Nature Singapore 09.03.2023; Springer
• Subjects: Anesthesia; Anesthesiology; Critical Care Medicine; Intensive; Medicine; Medicine & Public Health; Methylation; Neurosciences; Neurotoxicity; Original Research; Pharmacology/Toxicology; Sevoflurane; Shank2; Surgery; TET3; Sevoflurane; Anesthesia; Neurotoxicity; Methylation; TET3

Purpose Repeated exposures to sevoflurane could induce epigenetic modifications in specific brain regions and cognitive impairments in the immature mice. Conflicting findings make neurobehavioral manifestations intricate and potential mechanisms elusive. Influence of neonatal anesthesia with sevoflu...