JRK binds satellite III DNA and is necessary for the heat shock response

• Published in: Cell biology international Vol. 48; no. 8; pp. 1212 - 1222
• Main Authors: Waldron, Rosalie, Rodriguez, Maria de los Angeles Becerra, Williams, John M., Ning, Zhenfei, Ahmed, Abrar, Lindsay, Andrew, Moore, Tom
• Format: Journal Article
• Language: English
• Published: England Wiley Subscription Services, Inc 01.08.2024
• Subjects: Antisera; CENP‐B; centromere; Centromeres; Chromosome 9; Epilepsy; Gene expression; heat shock factor protein 1; Heat shock factors; heat shock protein; Heat shock proteins; Homology; Mental disorders; Phenotypes; Protein B; Proteins; Satellite DNA; Tcf protein; TIGGER; Transposons; satellite DNA; centromere; heat shock protein; heat shock factor protein 1; CENP‐B; TIGGER

JRK is a DNA‐binding protein of the pogo superfamily of transposons, which includes the well‐known centromere binding protein B (CENP‐B). Jrk null mice exhibit epilepsy, and growth and reproductive disorders, consistent with its relatively high expression in the brain and reproductive tissues. Human...