JRK binds satellite III DNA and is necessary for the heat shock response
JRK is a DNA‐binding protein of the pogo superfamily of transposons, which includes the well‐known centromere binding protein B (CENP‐B). Jrk null mice exhibit epilepsy, and growth and reproductive disorders, consistent with its relatively high expression in the brain and reproductive tissues. Human...
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| Published in | Cell biology international Vol. 48; no. 8; pp. 1212 - 1222 |
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| Main Authors | , , , , , , |
| Format | Journal Article |
| Language | English |
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01.08.2024
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| Abstract | JRK is a DNA‐binding protein of the pogo superfamily of transposons, which includes the well‐known centromere binding protein B (CENP‐B). Jrk null mice exhibit epilepsy, and growth and reproductive disorders, consistent with its relatively high expression in the brain and reproductive tissues. Human JRK DNA variants and gene expression levels are implicated in cancers and neuropsychiatric disorders. JRK protein modulates β‐catenin–TCF activity but little is known of its cellular functions. Based on its homology to CENP‐B, we determined whether JRK binds centromeric or other satellite DNAs. We show that human JRK binds satellite III DNA, which is abundant at the chromosome 9q12 juxtacentromeric region and on Yq12, both sites of nuclear stress body assembly. Human JRK‐GFP overexpressed in HeLa cells strongly localises to 9q12. Using an anti‐JRK antiserum we show that endogenous JRK co‐localises with a subset of centromeres in non‐stressed cells, and with heat shock factor 1 following heat shock. Knockdown of JRK in HeLa cells proportionately reduces heat shock protein gene expression in heat‐shocked cells. A role for JRK in regulating the heat shock response is consistent with the mouse Jrk null phenotype and suggests that human JRK may act as a modifier of diseases with a cellular stress component. |
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| AbstractList | JRK is a DNA‐binding protein of the pogo superfamily of transposons, which includes the well‐known centromere binding protein B (CENP‐B). Jrk null mice exhibit epilepsy, and growth and reproductive disorders, consistent with its relatively high expression in the brain and reproductive tissues. Human JRK DNA variants and gene expression levels are implicated in cancers and neuropsychiatric disorders. JRK protein modulates β‐catenin–TCF activity but little is known of its cellular functions. Based on its homology to CENP‐B, we determined whether JRK binds centromeric or other satellite DNAs. We show that human JRK binds satellite III DNA, which is abundant at the chromosome 9q12 juxtacentromeric region and on Yq12, both sites of nuclear stress body assembly. Human JRK‐GFP overexpressed in HeLa cells strongly localises to 9q12. Using an anti‐JRK antiserum we show that endogenous JRK co‐localises with a subset of centromeres in non‐stressed cells, and with heat shock factor 1 following heat shock. Knockdown of JRK in HeLa cells proportionately reduces heat shock protein gene expression in heat‐shocked cells. A role for JRK in regulating the heat shock response is consistent with the mouse Jrk null phenotype and suggests that human JRK may act as a modifier of diseases with a cellular stress component. JRK is a DNA-binding protein of the pogo superfamily of transposons, which includes the well-known centromere binding protein B (CENP-B). Jrk null mice exhibit epilepsy, and growth and reproductive disorders, consistent with its relatively high expression in the brain and reproductive tissues. Human JRK DNA variants and gene expression levels are implicated in cancers and neuropsychiatric disorders. JRK protein modulates β-catenin-TCF activity but little is known of its cellular functions. Based on its homology to CENP-B, we determined whether JRK binds centromeric or other satellite DNAs. We show that human JRK binds satellite III DNA, which is abundant at the chromosome 9q12 juxtacentromeric region and on Yq12, both sites of nuclear stress body assembly. Human JRK-GFP overexpressed in HeLa cells strongly localises to 9q12. Using an anti-JRK antiserum we show that endogenous JRK co-localises with a subset of centromeres in non-stressed cells, and with heat shock factor 1 following heat shock. Knockdown of JRK in HeLa cells proportionately reduces heat shock protein gene expression in heat-shocked cells. A role for JRK in regulating the heat shock response is consistent with the mouse Jrk null phenotype and suggests that human JRK may act as a modifier of diseases with a cellular stress component.JRK is a DNA-binding protein of the pogo superfamily of transposons, which includes the well-known centromere binding protein B (CENP-B). Jrk null mice exhibit epilepsy, and growth and reproductive disorders, consistent with its relatively high expression in the brain and reproductive tissues. Human JRK DNA variants and gene expression levels are implicated in cancers and neuropsychiatric disorders. JRK protein modulates β-catenin-TCF activity but little is known of its cellular functions. Based on its homology to CENP-B, we determined whether JRK binds centromeric or other satellite DNAs. We show that human JRK binds satellite III DNA, which is abundant at the chromosome 9q12 juxtacentromeric region and on Yq12, both sites of nuclear stress body assembly. Human JRK-GFP overexpressed in HeLa cells strongly localises to 9q12. Using an anti-JRK antiserum we show that endogenous JRK co-localises with a subset of centromeres in non-stressed cells, and with heat shock factor 1 following heat shock. Knockdown of JRK in HeLa cells proportionately reduces heat shock protein gene expression in heat-shocked cells. A role for JRK in regulating the heat shock response is consistent with the mouse Jrk null phenotype and suggests that human JRK may act as a modifier of diseases with a cellular stress component. |
| Author | Lindsay, Andrew Ahmed, Abrar Williams, John M. Ning, Zhenfei Waldron, Rosalie Rodriguez, Maria de los Angeles Becerra Moore, Tom |
| Author_xml | – sequence: 1 givenname: Rosalie surname: Waldron fullname: Waldron, Rosalie organization: University College Cork – sequence: 2 givenname: Maria de los Angeles Becerra surname: Rodriguez fullname: Rodriguez, Maria de los Angeles Becerra organization: University College Cork – sequence: 3 givenname: John M. surname: Williams fullname: Williams, John M. organization: University College Cork – sequence: 4 givenname: Zhenfei surname: Ning fullname: Ning, Zhenfei organization: University College Cork – sequence: 5 givenname: Abrar surname: Ahmed fullname: Ahmed, Abrar organization: University College Cork – sequence: 6 givenname: Andrew orcidid: 0000-0001-9693-7022 surname: Lindsay fullname: Lindsay, Andrew organization: University College Cork – sequence: 7 givenname: Tom orcidid: 0000-0001-9712-9625 surname: Moore fullname: Moore, Tom email: t.moore@ucc.ie organization: University College Cork |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/38946594$$D View this record in MEDLINE/PubMed |
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| Cites_doi | 10.1523/jneurosci.17-12-04562.1997 10.1096/fj00-0294rev 10.1073/pnas.93.8.3264 10.1016/s0920-1211(01)00275-3 10.3390/genes13010154 10.1083/jcb.200109018 10.1091/mbc.01-12-0569 10.1038/ng.152 10.1101/gr.275351.121 10.1016/s1046-2023(02)00006-3 10.1038/onc.2015.347 10.1196/annals.1391.032 10.1002/gene.10200 10.1038/35037669 10.1373/clinchem.2008.112797 10.1128/mcb.13.3.1392-1407.1993 10.1136/gutjnl-2015-310059 10.1371/journal.pgen.1006870 10.1006/abio.1976.9999 10.1083/jcb.200306104 10.3390/cancers13225837 10.1186/1471-2164-10-498 10.1023/a:1020694205003 10.1126/science.abl4178 10.1128/mcb.23.12.4083-4093.2003 10.1093/hmg/10.14.1511 10.1523/jneurosci.0006-07.2007 10.1073/pnas.96.12.6769 10.1093/emboj/21.11.2591 10.1128/mcb.15.3.1602 10.1038/ng0995-71 10.1002/gene.20005 10.1007/s00412-011-0348-3 10.1007/s00412-021-00751-2 10.1523/jneurosci.22-01-00176.2002 10.1016/s0015-0282(01)02892-8 10.1111/j.1365-2990.1991.tb00705.x 10.1038/emboj.2011.67 10.1523/jneurosci.4057-07.2007 10.1007/978-3-642-56348-5_13 10.1042/bst0320920 10.1152/japplphysiol.01267.2001 10.1242/jcs.01329 10.1126/science.1106478 10.1210/mend.15.4.0618 10.1007/bf00333988 10.1016/j.molcel.2021.09.022 10.1126/science.278.5344.1812 10.1016/j.nbd.2004.11.011 10.1379/csc-250.1 10.3390/genes12101524 10.1101/cshperspect.a000695 10.1073/pnas.1202189109 10.1111/j.0013-9580.2004.14904.x 10.1016/j.semcdb.2003.09.021 10.1016/0076-6879(90)82008-p 10.1186/s13100-020-00220-0 10.1093/molbev/msm221 10.1097/00004647-199611000-00011 |
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| Keywords | satellite DNA centromere heat shock protein heat shock factor protein 1 CENP‐B TIGGER |
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| References | 1997; 278 2022; 376 2004; 164 2012; 121 1991; 17 2002; 13 2002; 156 2003; 14 1990; 182 2020; 11 2001; 46 2016; 35 2000; 407 2004; 32 2009; 55 1998; 18 2009; 10 2001 2004; 38 1976; 72 1997; 17 2005; 307 2001; 15 2002; 92 1999; 96 2022; 32 2010; 2 2007; 25 2021; 81 2001; 10 2007; 27 1987; 95 1995; 15 2004; 45 1995; 11 2011; 30 1996; 93 2003; 36 1996; 16 2007; 12 2012; 109 2002; 28 2021; 13 1993; 13 2002; 26 2005; 19 2021; 12 2002; 21 2017; 13 2007; 1113 2002; 22 2016; 65 2022; 13 2021; 130 2008; 40 2004; 117 2001; 76 2003; 23 e_1_2_9_31_1 e_1_2_9_52_1 e_1_2_9_50_1 e_1_2_9_10_1 e_1_2_9_35_1 e_1_2_9_56_1 e_1_2_9_12_1 e_1_2_9_33_1 e_1_2_9_54_1 e_1_2_9_14_1 e_1_2_9_39_1 e_1_2_9_16_1 e_1_2_9_37_1 e_1_2_9_58_1 e_1_2_9_18_1 e_1_2_9_41_1 e_1_2_9_20_1 e_1_2_9_22_1 e_1_2_9_45_1 e_1_2_9_24_1 e_1_2_9_43_1 e_1_2_9_8_1 e_1_2_9_6_1 e_1_2_9_4_1 e_1_2_9_60_1 e_1_2_9_2_1 e_1_2_9_26_1 e_1_2_9_49_1 e_1_2_9_28_1 e_1_2_9_30_1 e_1_2_9_53_1 e_1_2_9_51_1 e_1_2_9_11_1 e_1_2_9_34_1 e_1_2_9_57_1 e_1_2_9_13_1 e_1_2_9_32_1 e_1_2_9_55_1 e_1_2_9_15_1 e_1_2_9_38_1 e_1_2_9_17_1 e_1_2_9_36_1 e_1_2_9_59_1 e_1_2_9_19_1 e_1_2_9_42_1 e_1_2_9_40_1 e_1_2_9_61_1 e_1_2_9_21_1 e_1_2_9_46_1 e_1_2_9_23_1 e_1_2_9_44_1 e_1_2_9_7_1 e_1_2_9_5_1 e_1_2_9_3_1 e_1_2_9_9_1 e_1_2_9_25_1 e_1_2_9_27_1 e_1_2_9_48_1 Sambrook J. (e_1_2_9_47_1) 2001 e_1_2_9_29_1 |
| References_xml | – volume: 32 start-page: 608 issue: 4 year: 2022 end-page: 615 article-title: The genetics and epigenetics of satellite centromeres publication-title: Genome Research – volume: 14 start-page: 283 year: 2003 end-page: 290 article-title: Heat shock proteins in mammalian development publication-title: Seminars in Cell & Developmental Biology – volume: 109 start-page: 4974 issue: 13 year: 2012 end-page: 4979 article-title: Common genetic variants in the gene influence gene expression and bladder cancer risk publication-title: Proceedings of the National Academy of Sciences – volume: 11 start-page: 25 year: 2020 article-title: Evolution of pogo, a separate superfamily of IS630‐Tc1‐mariner transposons, revealing recurrent domestication events in vertebrates publication-title: Mobile DNA – volume: 36 start-page: 48 issue: 1 year: 2003 end-page: 61 article-title: Targeted disruption of the heat shock transcription factor (hsf)‐2 gene results in increased embryonic lethality, neuronal defects, and reduced spermatogenesis publication-title: Genesis – volume: 376 issue: 6588 year: 2022 article-title: Complete genomic and epigenetic maps of human centromeres publication-title: Science – volume: 55 start-page: 611 issue: 4 year: 2009 end-page: 622 article-title: The MIQE guidelines: Minimum information for publication of quantitative real‐time PCR experiments publication-title: Clinical Chemistry – year: 2001 – volume: 22 start-page: 176 issue: 1 year: 2002 end-page: 182 article-title: Jerky, a protein deficient in a mouse epilepsy model, is associated with translationally inactive mRNA in neurons publication-title: The Journal of Neuroscience – volume: 17 start-page: 139 year: 1991 end-page: 147 article-title: Heat shock in cultured neurons and astrocytes: Correlation of ultrastructure and heat shock protein synthesis publication-title: Neuropathology and Applied Neurobiology – volume: 35 start-page: 2834 issue: 22 year: 2016 end-page: 2841 article-title: JRK is a positive regulator of β‐catenin transcriptional activity commonly overexpressed in colon, breast and ovarian cancer publication-title: Oncogene – volume: 16 start-page: 1165 year: 1996 end-page: 1175 article-title: DNA fragmentation and HSP70 protein induction in hippocampus and cortex occurs in separate neurons following permanent middle cerebral artery occlusions publication-title: Journal of Cerebral Blood Flow & Metabolism – volume: 92 start-page: 2177 issue: 5 year: 2002 end-page: 2186 article-title: Invited review: Heat shock proteins: Modifying factors in physiological stress responses and acquired thermotolerance publication-title: Journal of Applied Physiology – volume: 21 start-page: 2591 issue: 11 year: 2002 end-page: 2601 article-title: Brain abnormalities, defective meiotic chromosome synapsis and female subfertility in HSF2 null mice publication-title: The EMBO Journal – volume: 407 start-page: 693 issue: 6805 year: 2000 end-page: 694 article-title: Maternal effect of Hsf1 on reproductive success publication-title: Nature – volume: 12 issue: 10 year: 2021 article-title: The role of human satellite III (1q12) copy number variation in the adaptive response during aging, stress, and pathology: A pendulum model publication-title: Genes – volume: 27 start-page: 7974 issue: 30 year: 2007 end-page: 7986 article-title: Demyelination, astrogliosis, and accumulation of ubiquitinated proteins, hallmarks of CNS disease in hsf1‐deficient mice publication-title: The Journal of Neuroscience – volume: 2 issue: 6 year: 2010 article-title: Nuclear stress bodies publication-title: Cold Spring Harbor Perspectives in Biology – volume: 278 start-page: 1812 year: 1997 end-page: 1815 article-title: Requirement of NF‐κB activation to suppress p53‐independent apoptosis induced by oncogenic ras publication-title: Science – volume: 307 start-page: 421 issue: 5708 year: 2005 end-page: 423 article-title: Mechanism of hsp70i gene bookmarking publication-title: Science – volume: 65 start-page: 361 issue: 2 year: 2016 end-page: 364 article-title: Functional annotation of high‐quality SNP biomarkers of gastric cancer susceptibility: The Yin Yang of rs2294008 publication-title: Gut – volume: 156 start-page: 775 year: 2002 end-page: 781 article-title: In vivo binding of active heat shock transcription factor 1 to human chromosome 9 heterochromatin during stress publication-title: The Journal of Cell Biology – volume: 40 start-page: 730 issue: 6 year: 2008 end-page: 740 article-title: Genetic variation in PSCA is associated with susceptibility to diffuse‐type gastric cancer publication-title: Nature Genetics – volume: 10 year: 2009 article-title: Inherent promoter bidirectionality facilitates maintenance of sequence integrity and transcription of parasitic DNA in mammalian genomes publication-title: BMC Genomics – volume: 117 start-page: 4551 issue: Pt 19 year: 2004 end-page: 4558 article-title: A key role for stress‐induced satellite III transcripts in the relocalization of splicing factors into nuclear stress granules publication-title: Journal of Cell Science – volume: 81 start-page: 4843 issue: 23 year: 2021 end-page: 4860.e8 article-title: Gene bookmarking by the heat shock transcription factor programs the insulin‐like signaling pathway publication-title: Molecular Cell – volume: 182 start-page: 50 year: 1990 end-page: 68 article-title: Quantitation of protein publication-title: Methods in Enzymology – volume: 13 issue: 7 year: 2017 article-title: Intestinal stem cell overproliferation resulting from inactivation of the APC tumor suppressor requires the transcription cofactors earthbound and erect wing publication-title: PLoS Genetics – volume: 72 start-page: 248 year: 1976 end-page: 254 article-title: A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein‐dye binding publication-title: Analytical Biochemistry – volume: 45 start-page: 1549 issue: 12 year: 2004 end-page: 1559 article-title: Heat shock protein‐27 is upregulated in the temporal cortex of patients with epilepsy publication-title: Epilepsia – volume: 96 start-page: 6769 issue: 12 year: 1999 end-page: 6774 article-title: Rapid and reversible relocalization of heat shock factor 1 within seconds to nuclear stress granules publication-title: Proceedings of the National Academy of Sciences – volume: 13 issue: 1 year: 2022 article-title: Genotype‐phenotype comparison in POGZ‐related neurodevelopmental disorders by using clinical scoring publication-title: Genes – volume: 13 start-page: 1392 issue: 3 year: 1993 end-page: 1407 article-title: Activation of heat‐shock gene‐transcription by Heat‐Shock Factor‐1 involves oligomerization, acquisition of DNA‐binding activity, and nuclear‐localization and can occur in the absence of stress publication-title: Molecular and Cellular Biology – volume: 95 start-page: 375 issue: 6 year: 1987 end-page: 386 article-title: Human chromosome‐specific repetitive DNA sequences: novel markers for genetic analysis publication-title: Chromosoma – volume: 25 start-page: 29 issue: 1 year: 2007 end-page: 41 article-title: Convergent domestication of pogo‐like transposases into centromere‐binding proteins in fission yeast and mammals publication-title: Molecular Biology and Evolution – volume: 23 start-page: 4083 issue: 12 year: 2003 end-page: 4093 article-title: The RNA binding domain of jerky consists of tandemly arranged helix‐turn‐helix/homeodomain‐like motifs and binds specific sets of mRNAs publication-title: Molecular and Cellular Biology – volume: 93 start-page: 3264 issue: 8 year: 1996 end-page: 3268 article-title: Targeted gene disruption of Hsp70‐2 results in failed meiosis, germ cell apoptosis, and male infertility publication-title: Proceedings of the National Academy of Sciences – volume: 130 start-page: 53 issue: 1 year: 2021 end-page: 60 article-title: Chromosome Y pericentric heterochromatin is a primary target of HSF1 in male cells publication-title: Chromosoma – volume: 26 start-page: 37 year: 2002 end-page: 47 article-title: Identification of unknown target genes of human transcription factors using chromatin immunoprecipitation publication-title: Methods – volume: 38 start-page: 66 issue: 2 year: 2004 end-page: 80 article-title: Essential requirement for both hsf1 and hsf2 transcriptional activity in spermatogenesis and male fertility publication-title: Genesis – volume: 76 start-page: 1136 issue: 6 year: 2001 end-page: 1139 article-title: Decreased expression of the heat shock protein hsp70‐2 is associated with the pathogenesis of male infertility publication-title: Fertility and Sterility – volume: 17 start-page: 4562 issue: 12 year: 1997 end-page: 4569 article-title: Sensitivity to jerky gene dosage underlies epileptic seizures in mice publication-title: The Journal of Neuroscience – volume: 27 start-page: 13173 issue: 48 year: 2007 end-page: 13180 article-title: Exogenous delivery of heat shock protein 70 increases lifespan in a mouse model of amyotrophic lateral sclerosis publication-title: The Journal of Neuroscience – volume: 28 start-page: 235 year: 2002 end-page: 251 article-title: Hsp27 in the nervous system: Expression in pathophysiology and in the aging brain publication-title: Progress in Molecular and Subcellular Biology – volume: 10 start-page: 1511 issue: 14 year: 2001 end-page: 1518 article-title: Over‐expression of inducible HSP70 chaperone suppresses neuropathology and improves motor function in SCA1 mice publication-title: Human Molecular Genetics – volume: 11 start-page: 71 issue: 1 year: 1995 end-page: 75 article-title: Epileptic seizures caused by inactivation of a novel gene, jerky, related to centromere‐binding protein‐B in transgenic mice publication-title: Nature Genetics – volume: 13 issue: 22 year: 2021 article-title: A novel four‐gene prognostic signature for prediction of survival in patients with soft tissue sarcoma publication-title: Cancers – volume: 32 start-page: 920 issue: Pt year: 2004 end-page: 923 article-title: Complex regulation and nuclear localization of JRK protein publication-title: Biochemical Society Transactions – volume: 1113 start-page: 147 year: 2007 end-page: 158 article-title: Heat shock proteins and protection of the nervous system publication-title: Annals of the New York Academy of Sciences – volume: 15 start-page: 1602 issue: 3 year: 1995 end-page: 1612 article-title: Analysis of protein‐DNA and protein‐protein interactions of centromere protein B (CENP‐B) and properties of the DNA‐CENP‐B complex in the cell cycle publication-title: Molecular and Cellular Biology – volume: 13 start-page: 2069 issue: 6 year: 2002 end-page: 2079 article-title: Human chromosomes 9, 12, and 15 contain the nucleation sites of stress‐induced nuclear bodies publication-title: Molecular Biology of the Cell – volume: 164 start-page: 25 issue: 1 year: 2004 end-page: 33 article-title: Stress induced transcription of satellite III repeats publication-title: The Journal of Cell Biology – volume: 30 start-page: 1444 issue: 8 year: 2011 end-page: 1458 article-title: Jerky/Earthbound facilitates cell‐specific Wnt/Wingless signalling by modulating β‐catenin–TCF activity publication-title: The EMBO Journal – volume: 46 start-page: 157 issue: 2 year: 2001 end-page: 167 article-title: Polymorphism analysis of JRK/JH8, the human homologue of mouse jerky, and description of a rare mutation in a case of CAE evolving to JME publication-title: Epilepsy Research – volume: 15 start-page: 485 issue: 4 year: 2001 end-page: 500 article-title: The glucocorticoid receptor interacting protein 1 (GRIP1) localizes in discrete nuclear foci that associate with ND10 bodies and are enriched in components of the 26S proteasome publication-title: Molecular Endocrinology – volume: 18 start-page: 709 year: 1998 end-page: 719 article-title: Stress protein inductions after brain ischemia publication-title: Cellular and Molecular Neurobiology – volume: 19 start-page: 142 issue: 1–2 year: 2005 end-page: 149 article-title: Transient hyperthermia protects against subsequent seizures and epilepsy‐induced cell damage in the rat publication-title: Neurobiology of Disease – volume: 15 start-page: 1118 year: 2001 end-page: 1131 article-title: Roles of the heat shock transcription factors in regulation of the heat shock response and beyond publication-title: The FASEB Journal – volume: 121 start-page: 169 issue: 2 year: 2012 end-page: 179 article-title: Putative CENP‐B paralogues are not present at mammalian centromeres publication-title: Chromosoma – volume: 12 start-page: 283 issue: 3 year: 2007 end-page: 290 article-title: HSF2 binds to the Hsp90, Hsp27, and c‐Fos promoters constitutively and modulates their expression publication-title: Cell Stress & Chaperones – ident: e_1_2_9_18_1 doi: 10.1523/jneurosci.17-12-04562.1997 – ident: e_1_2_9_44_1 doi: 10.1096/fj00-0294rev – ident: e_1_2_9_17_1 doi: 10.1073/pnas.93.8.3264 – ident: e_1_2_9_38_1 doi: 10.1016/s0920-1211(01)00275-3 – ident: e_1_2_9_40_1 doi: 10.3390/genes13010154 – ident: e_1_2_9_26_1 doi: 10.1083/jcb.200109018 – ident: e_1_2_9_16_1 doi: 10.1091/mbc.01-12-0569 – ident: e_1_2_9_46_1 doi: 10.1038/ng.152 – ident: e_1_2_9_52_1 doi: 10.1101/gr.275351.121 – ident: e_1_2_9_58_1 doi: 10.1016/s1046-2023(02)00006-3 – volume-title: Molecular cloning: A Laboratory Manual year: 2001 ident: e_1_2_9_47_1 contributor: fullname: Sambrook J. – ident: e_1_2_9_42_1 doi: 10.1038/onc.2015.347 – ident: e_1_2_9_9_1 doi: 10.1196/annals.1391.032 – ident: e_1_2_9_56_1 doi: 10.1002/gene.10200 – ident: e_1_2_9_12_1 doi: 10.1038/35037669 – ident: e_1_2_9_10_1 doi: 10.1373/clinchem.2008.112797 – ident: e_1_2_9_48_1 doi: 10.1128/mcb.13.3.1392-1407.1993 – ident: e_1_2_9_51_1 doi: 10.1136/gutjnl-2015-310059 – ident: e_1_2_9_53_1 doi: 10.1371/journal.pgen.1006870 – ident: e_1_2_9_8_1 doi: 10.1006/abio.1976.9999 – ident: e_1_2_9_27_1 doi: 10.1083/jcb.200306104 – ident: e_1_2_9_60_1 doi: 10.3390/cancers13225837 – ident: e_1_2_9_28_1 doi: 10.1186/1471-2164-10-498 – ident: e_1_2_9_2_1 doi: 10.1023/a:1020694205003 – ident: e_1_2_9_3_1 doi: 10.1126/science.abl4178 – ident: e_1_2_9_34_1 doi: 10.1128/mcb.23.12.4083-4093.2003 – ident: e_1_2_9_14_1 doi: 10.1093/hmg/10.14.1511 – ident: e_1_2_9_24_1 doi: 10.1523/jneurosci.0006-07.2007 – ident: e_1_2_9_25_1 doi: 10.1073/pnas.96.12.6769 – ident: e_1_2_9_29_1 doi: 10.1093/emboj/21.11.2591 – ident: e_1_2_9_30_1 doi: 10.1128/mcb.15.3.1602 – ident: e_1_2_9_54_1 doi: 10.1038/ng0995-71 – ident: e_1_2_9_57_1 doi: 10.1002/gene.20005 – ident: e_1_2_9_35_1 doi: 10.1007/s00412-011-0348-3 – ident: e_1_2_9_43_1 doi: 10.1007/s00412-021-00751-2 – ident: e_1_2_9_33_1 doi: 10.1523/jneurosci.22-01-00176.2002 – ident: e_1_2_9_20_1 doi: 10.1016/s0015-0282(01)02892-8 – ident: e_1_2_9_41_1 doi: 10.1111/j.1365-2990.1991.tb00705.x – ident: e_1_2_9_5_1 doi: 10.1038/emboj.2011.67 – ident: e_1_2_9_23_1 doi: 10.1523/jneurosci.4057-07.2007 – ident: e_1_2_9_32_1 doi: 10.1007/978-3-642-56348-5_13 – ident: e_1_2_9_55_1 doi: 10.1042/bst0320920 – ident: e_1_2_9_31_1 doi: 10.1152/japplphysiol.01267.2001 – ident: e_1_2_9_37_1 doi: 10.1242/jcs.01329 – ident: e_1_2_9_61_1 doi: 10.1126/science.1106478 – ident: e_1_2_9_4_1 doi: 10.1210/mend.15.4.0618 – ident: e_1_2_9_39_1 doi: 10.1007/bf00333988 – ident: e_1_2_9_15_1 doi: 10.1016/j.molcel.2021.09.022 – ident: e_1_2_9_36_1 doi: 10.1126/science.278.5344.1812 – ident: e_1_2_9_19_1 doi: 10.1016/j.nbd.2004.11.011 – ident: e_1_2_9_59_1 doi: 10.1379/csc-250.1 – ident: e_1_2_9_45_1 doi: 10.3390/genes12101524 – ident: e_1_2_9_6_1 doi: 10.1101/cshperspect.a000695 – ident: e_1_2_9_21_1 doi: 10.1073/pnas.1202189109 – ident: e_1_2_9_7_1 doi: 10.1111/j.0013-9580.2004.14904.x – ident: e_1_2_9_13_1 doi: 10.1016/j.semcdb.2003.09.021 – ident: e_1_2_9_50_1 doi: 10.1016/0076-6879(90)82008-p – ident: e_1_2_9_22_1 doi: 10.1186/s13100-020-00220-0 – ident: e_1_2_9_11_1 doi: 10.1093/molbev/msm221 – ident: e_1_2_9_49_1 doi: 10.1097/00004647-199611000-00011 |
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| Snippet | JRK is a DNA‐binding protein of the pogo superfamily of transposons, which includes the well‐known centromere binding protein B (CENP‐B). Jrk null mice exhibit... JRK is a DNA-binding protein of the pogo superfamily of transposons, which includes the well-known centromere binding protein B (CENP-B). Jrk null mice exhibit... |
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| SubjectTerms | Antisera CENP‐B centromere Centromeres Chromosome 9 Epilepsy Gene expression heat shock factor protein 1 Heat shock factors heat shock protein Heat shock proteins Homology Mental disorders Phenotypes Protein B Proteins Satellite DNA Tcf protein TIGGER Transposons |
| Title | JRK binds satellite III DNA and is necessary for the heat shock response |
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