Pharmacological properties of buprenorphine, a new analgesic agent. Part II. (author's transl)

• Published in: Nihon yakurigaku zasshi Vol. 79; no. 3; p. 173
• Main Authors: Shintani, S, Umezato, M, Toba, Y, Yamaji, Y, Kitaura, K, Tani, T, Ishiyama, H, Kikuchi, T, Mori, T, Nakai, S, Watanabe, K, Hiyama, T
• Format: Journal Article
• Language: Japanese
• Published: Japan 1982
• Subjects: Analgesics, Opioid - pharmacology; Animals; Arousal - drug effects; Buprenorphine - pharmacology; Cerebrovascular Circulation - drug effects; Coronary Circulation - drug effects; Dogs; Electroencephalography; Emetics; Female; Hemodynamics - drug effects; Hypothalamus - drug effects; Kidney - physiology; Male; Morphinans - pharmacology; Morphine - pharmacology; Myocardial Contraction - drug effects; Rabbits; Rats; Rats, Inbred Strains; Recruitment, Neurophysiological - drug effects; Sleep - drug effects; Wakefulness - drug effects

Pharmacological properties of buprenorphine were compared with those of morphine and pentazocine. Buprenorphine scarcely showed any effects on spontaneous EEGs and sleep-wakefulness cycles. Buprenorphine tended to depress the recruiting and augmenting responses and the spindle burst, and it also inh...