Impaired instructive and protective barrier functions of the endothelial cell glycocalyx pericellular matrix is impacted in COVID‐19 disease

• Published in: Journal of cellular and molecular medicine Vol. 28; no. 16; pp. e70033 - n/a
• Main Authors: Smith, Margaret M., Melrose, James
• Format: Journal Article
• Language: English
• Published: England John Wiley & Sons, Inc 01.08.2024
• Subjects: Biosensors; blood flow regulation; Blood pressure; Blood vessels; Blood-brain barrier; Blood-Brain Barrier - drug effects; Blood-Brain Barrier - metabolism; Cells; Central nervous system; COVID-19; COVID-19 - metabolism; COVID-19 - pathology; COVID-19 - virology; Cytokines; Disease; endothelial cell; Endothelial cells; Endothelial Cells - metabolism; Endothelial Cells - pathology; endothelium; Extracellular matrix; glycocalyx; Glycocalyx - metabolism; Glycoproteins; Glycosaminoglycans; Glycosaminoglycans - metabolism; glypican; Growth factors; Homeostasis; Humans; Hyaluronic acid; Hypertension; Inflammation; Information processing; Kinases; Leukocytes; Long COVID; Medical treatment; Metabolism; Molecular weight; Nitric oxide; Oxidative stress; perlecan; Permeability; Proteins; SARS-CoV-2 - drug effects; SARS-CoV-2 - metabolism; Severe acute respiratory syndrome coronavirus 2; shear flow; Smooth muscle; smooth muscle cell regulation; syndecan; Tight junctions; Viral infections; glycocalyx; endothelium; COVID‐19; blood flow regulation; shear flow; endothelial cell; perlecan; syndecan; smooth muscle cell regulation; glypican

The aim of this study was to review the roles of endothelial cells in normal tissue function and to show how COVID‐19 disease impacts on endothelial cell properties that lead to much of its associated symptomatology. This places the endothelial cell as a prominent cell type to target therapeutically...