64. Comparison of the effects of topical and intravenous administration of tranexamic acid on postoperative blood loss in single-level posterior lumbar interbody fusion

• Published in: North American Spine Society journal (NASSJ) Vol. 18; p. 100402
• Main Authors: Kitaguchi, Kazuma, Kaito, Takashi, Wada, Eiji
• Format: Journal Article
• Language: English
• Published: Elsevier Inc 01.07.2024
• Subjects: Orthopedics

Tranexamic acid (TXA), a synthetic antifibrinolytic drug, competitively blocks the lysine-binding sites of plasminogen, plasmin, and tissue plasminogen activator, thus reducing bleeding. Intravenous TXA has been used to effectively reduce perioperative blood loss in spinal surgery. However, high-dos...