First structurally defined catalyst for the asymmetric addition of trimethylsilyl cyanide to benzaldehyde

Titanium complex TiCl2L [H2L = (R,R)-N,N'-bis(3,5-ditert-butylsalicylidene)hexane-1,2-diamine] 2 has been prepared, characterised by X-ray crystallography and shown to be an active catalyst for the asymmetric addition of Me3SiCN to benzaldehyde, producing ((S)-2-phenyl-2-trimethylsilyloxyaceton...

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Bibliographic Details
Published inChemical communications (Cambridge, England) no. 3; pp. 387 - 388
Main Authors Tararov, Hibbs, DE, Hursthouse, MB, Ikonnikov, NS, Malik, KMA, North, M, Orizu, C, Belokon, YN
Format Journal Article
LanguageEnglish
Published CAMBRIDGE Royal Soc Chemistry 07.02.1998
Subjects
Chemistry
Chemistry, Multidisciplinary
Physical Sciences
Science & Technology
COMPLEX
ALKYLATION
ARYLATION
LINEAR TITANOXANES
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Summary:Titanium complex TiCl2L [H2L = (R,R)-N,N'-bis(3,5-ditert-butylsalicylidene)hexane-1,2-diamine] 2 has been prepared, characterised by X-ray crystallography and shown to be an active catalyst for the asymmetric addition of Me3SiCN to benzaldehyde, producing ((S)-2-phenyl-2-trimethylsilyloxyacetonitrile in 86% ee at room temperature.
ISSN:1359-7345
1364-548X
DOI:10.1039/a706121h