Prevalence of human herpesvirus in plasma and saliva of cirrhotic patients: A pilot study

• Published in: Special care in dentistry
• Main Authors: Bueno Marinho, Gabriella, Bertoldi Franco, Juliana, Tenório, Jefferson R, Silva Andrade, Natália, Zerbinati, Rodrigo Melim, Medina, Janaína B, Pérez-Sayáns, Mário, Braz-Silva, Paulo Henrique, Ortega, Karem L
• Format: Journal Article
• Language: English
• Published: United States 10.05.2024
• Subjects: EBV; HHV‐7; cirrhosis‐associated immune dysfunction; human herpesvirus; liver cirrhosis
• ISSN: 1754-4505
• DOI: 10.1111/scd.13016

The objective of this study was to identify the presence of human herpesvirus (HHV) in the plasma and saliva of hepatic-cirrhosis patients and correlate it with clinical data and laboratory tests. This is a pilot, observational, and cross-sectional study. Specimens of plasma and saliva from 72 cirrhotic individuals were analyzed by means of polymerase chain reaction. The patient population had a mean age of 54.84 years old (SD ± 10) and was 70% males (51/72). Approximately 47% (n = 34) of the patients had leukopenia and HHV was not identified in the plasma specimens. The main species of HHV identified in the saliva were HHV-7 (n = 42, 62%) and Epstein-Barr virus (EBV) (n = 30, 41%). Moreover, there was a significant decrease in the total number of leukocytes and lymphocytes in saliva containing EBV (P = .038 and P = .047, respectively). The results show that the presence of EBV in the saliva of cirrhotic patients was correlated with their circulating immune status. It may be possible that the immune dysfunction displayed by the cirrhotic patients plays a role in the shedding of EBV into saliva.