Pseudoxazolones, a new class of inhibitors for cysteine proteinases: inhibition of hepatitis A virus and human rhinovirus 3C proteinases

Monophenyl and diphenyl pseudoxazolone derivatives of glycine and alanine were prepared and found to be time-dependent inhibitors of hepatitis A virus (HAV) 3C and human rhinovirus (HRV) 3C proteinases with IC50 values in the micromolar range.

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Bibliographic Details
Published inChemical communications (Cambridge, England) no. 24; pp. 2740 - 2741
Main Authors Ramtohul, YK, Martin, NI, Silkin, L, James, MNG, Vederas, JC
Format Journal Article
LanguageEnglish
Published CAMBRIDGE Royal Soc Chemistry 19.12.2001
Subjects
Chemistry
Chemistry, Multidisciplinary
Physical Sciences
Science & Technology
DESIGN
CRYSTAL-STRUCTURE
PROTEASE
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Summary:Monophenyl and diphenyl pseudoxazolone derivatives of glycine and alanine were prepared and found to be time-dependent inhibitors of hepatitis A virus (HAV) 3C and human rhinovirus (HRV) 3C proteinases with IC50 values in the micromolar range.
ISSN:1359-7345
1364-548X
DOI:10.1039/b109095j