Novel targets in the treatment of neuroendocrine tumors: RBP2

• Published in: International journal of endocrine oncology Vol. 4; no. 1; pp. 31 - 41
• Main Authors: Maggi, Elaine C, Crabtree, Judy S
• Format: Journal Article
• Language: English
• Published: London Future Medicine Ltd 01.03.2017
• Subjects: Cancer; carcinoid; Cell cycle; Cyclin-dependent kinases; Deoxyribonucleic acid; DNA; Drug resistance; Epigenetics; Gene expression; Intellectual disabilities; JARID1A; KDM5A; Kinases; Localization; Lung cancer; NET; neuroendocrine; Neuroendocrine tumors; Notch; pNET; Proteins; RBP2; Retina; Retinoblastoma; small cell lung carcinoma/SCLC; Telomerase

Retinoblastoma binding protein 2, also known as RBP2, JARID1A or KDM5A, is an H3K4 demethylase implicated in a variety of non-neuroendocrine, and more recently, neuroendocrine tumors (NETs). NETs are tumors that form from neuroendocrine cells in tissues of the GI tract, endocrine pancreas, lung, ski...