Hyperpolarizing 'alpha 2'-adrenoceptors in rat sympathetic ganglia

• Published in: British journal of pharmacology Vol. 65; no. 3; pp. 435 - 445
• Main Authors: Brown, D A, Caulfield, M P
• Format: Journal Article
• Language: English
• Published: England 01.03.1979
• Subjects: Animals; Catecholamines - pharmacology; Clonidine - pharmacology; Ganglia, Autonomic - physiology; In Vitro Techniques; Isoproterenol - pharmacology; Male; Norepinephrine - metabolism; Oxymetazoline - pharmacology; Phentolamine - pharmacology; Propranolol - pharmacology; Rats; Receptors, Adrenergic - physiology; Receptors, Adrenergic, alpha - drug effects; Receptors, Adrenergic, alpha - physiology; Receptors, Dopamine - drug effects; Time Factors

1 Receptors mediating catecholamine-induced hyperpolarization of isolated superior cervical sympathetic ganglia of the rat have been characterized by means of an extracellular recording method.2 (-)-Noradrenaline (EC(50), 1.7 +/- 0.6 muM) produced an immediate low-amplitude (< 400 muV) hyperpolar...