The effect of Vitamin B6 on chemotherapy induced nausea and vomiting in pediatric cancer
Background: Nausea and vomiting are the common side-effects of chemotherapy in children with malignancy. In this study, the effectiveness of vitamin B6 in reducing the chemo-induced nausea and vomiting (CINV) in children was tested. Material and methods: A triple-blind clinical trials was performed...
Saved in:
Published in | Iranian journal of pediatric hematology and oncology |
---|---|
Main Authors | , , , , , , |
Format | Journal Article |
Language | English |
Published |
01.01.2020
|
Online Access | Get full text |
Cover
Loading…
Abstract | Background: Nausea and vomiting are the common side-effects of chemotherapy in children with malignancy. In this study, the effectiveness of vitamin B6 in reducing the chemo-induced nausea and vomiting (CINV) in children was tested.
Material and methods: A triple-blind clinical trials was performed on 100 children with malignancy referring to the pediatric clinic of Amir Kabir Hospital, Arak, Iran. Besides the infusion of granisetron (3mg/3ml) half an hour before each chemotherapy cycle, an intravenous dose of vitamin B6 (100 mg for children from 2 to 5 years old, 200 mg for children from 5 to 10 years old, and 300 mg for children older than 10) was given 6 hours before the first chemotherapy cycle and placebo was injected (2-5 years old: 100 mg, 5-10 years old: 200 mg, age≥ 10 years old: 300mg) 6 hours before the second cycle. Then the severity of nausea and the frequency of vomiting episodes in each cycle were recorded to be compared.
Results: The mean age of children was 7.98 ± 3.133 years old. The most common and rare malignancy were acute lymphocytic leukemia (ALL) (46%) and ependymoma (0.5%), respectively. Vincristin was the most commonly used chemotherapy agent (28%). A positive correlation between the severity of nausea(R=0.313, P-value=0.0016) and frequency of vomiting with age was found (R=0.319, P-value=0.0012). However, no noticeable association was observed between N/V and gender (P-value.0.05). There was a considerable correlation between the frequency of vomiting and different tumor types in this study (P-value=0.0006).In comparison with placebo, Vitamin B6 significantly reduced the severity of nausea (P = 0.0001) as well as the frequency of vomiting (P-value = 0.0005). It was also more effective in ALL compared to rhabdomyosarcoma (P-value=0.001).
Conclusion: This study suggested that vitamin B6 can be considered as an appropriate alternative to treat CINV in children with malignancy. |
---|---|
AbstractList | Background: Nausea and vomiting are the common side-effects of chemotherapy in children with malignancy. In this study, the effectiveness of vitamin B6 in reducing the chemo-induced nausea and vomiting (CINV) in children was tested.
Material and methods: A triple-blind clinical trials was performed on 100 children with malignancy referring to the pediatric clinic of Amir Kabir Hospital, Arak, Iran. Besides the infusion of granisetron (3mg/3ml) half an hour before each chemotherapy cycle, an intravenous dose of vitamin B6 (100 mg for children from 2 to 5 years old, 200 mg for children from 5 to 10 years old, and 300 mg for children older than 10) was given 6 hours before the first chemotherapy cycle and placebo was injected (2-5 years old: 100 mg, 5-10 years old: 200 mg, age≥ 10 years old: 300mg) 6 hours before the second cycle. Then the severity of nausea and the frequency of vomiting episodes in each cycle were recorded to be compared.
Results: The mean age of children was 7.98 ± 3.133 years old. The most common and rare malignancy were acute lymphocytic leukemia (ALL) (46%) and ependymoma (0.5%), respectively. Vincristin was the most commonly used chemotherapy agent (28%). A positive correlation between the severity of nausea(R=0.313, P-value=0.0016) and frequency of vomiting with age was found (R=0.319, P-value=0.0012). However, no noticeable association was observed between N/V and gender (P-value.0.05). There was a considerable correlation between the frequency of vomiting and different tumor types in this study (P-value=0.0006).In comparison with placebo, Vitamin B6 significantly reduced the severity of nausea (P = 0.0001) as well as the frequency of vomiting (P-value = 0.0005). It was also more effective in ALL compared to rhabdomyosarcoma (P-value=0.001).
Conclusion: This study suggested that vitamin B6 can be considered as an appropriate alternative to treat CINV in children with malignancy. |
Author | Eghbali, Aygin Farokhmehr, Golrokh Zahedi, Sima Eghbali, Aziz Mousavi-Hasanzadeh, Morteza Adelnia, Arefeh Mehrabi, Sarvenaz |
Author_xml | – sequence: 1 givenname: Morteza surname: Mousavi-Hasanzadeh fullname: Mousavi-Hasanzadeh, Morteza – sequence: 2 givenname: Arefeh surname: Adelnia fullname: Adelnia, Arefeh – sequence: 3 givenname: Golrokh surname: Farokhmehr fullname: Farokhmehr, Golrokh – sequence: 4 givenname: Sarvenaz surname: Mehrabi fullname: Mehrabi, Sarvenaz – sequence: 5 givenname: Sima surname: Zahedi fullname: Zahedi, Sima – sequence: 6 givenname: Aygin surname: Eghbali fullname: Eghbali, Aygin – sequence: 7 givenname: Aziz surname: Eghbali fullname: Eghbali, Aziz |
BookMark | eNpNkE9LAzEUxIMoWGs_gLd8ga1JNml3j1r8BwUvVbwtLy8vboqbLNltod_eWj04MMzAwBx-V-w8pkiM3Ugxl5UR6jZs-zbN91IEOVdyoc_YRAlRFVVVq_N__ZLNhmErjloIaYSesI9NS5y8Jxx58vw9jNCFyO8XPEWOLXVpbClDf-Ahuh2S4xF2AwGH6Pg-dWEM8fO48Z5cgDEH5AgRKV-zCw9fA83-csreHh82q-di_fr0srpbF6i0GQu7VJV22pvSS3n0EpxEdOhA1ba0pUOrsLa1qbWx4HytpCXjjRbae62hnDL5-4s5DUMm3_Q5dJAPjRTNiU5zotOc6DQ_dMpv3t9dDQ |
CitedBy_id | crossref_primary_10_1007_s00404_023_06925_w |
ContentType | Journal Article |
DBID | AAYXX CITATION |
DOI | 10.18502/ijpho.v10i1.2164 |
DatabaseName | CrossRef |
DatabaseTitle | CrossRef |
DatabaseTitleList | CrossRef |
DeliveryMethod | fulltext_linktorsrc |
Discipline | Medicine |
EISSN | 2008-8892 |
ExternalDocumentID | 10_18502_ijpho_v10i1_2164 |
GroupedDBID | AAYXX ABDBF ADBBV ALMA_UNASSIGNED_HOLDINGS BAWUL CITATION DIK ESX KQ8 M~E OK1 RNS RPM TUS |
ID | FETCH-LOGICAL-c245t-b7284d4f53f113f17ad1ccdcda29b3b3dcb2c9b95945badf921be5f5404ff44a3 |
ISSN | 2008-8892 |
IngestDate | Fri Aug 23 03:46:59 EDT 2024 |
IsPeerReviewed | false |
IsScholarly | true |
Language | English |
LinkModel | OpenURL |
MergedId | FETCHMERGED-LOGICAL-c245t-b7284d4f53f113f17ad1ccdcda29b3b3dcb2c9b95945badf921be5f5404ff44a3 |
ParticipantIDs | crossref_primary_10_18502_ijpho_v10i1_2164 |
PublicationCentury | 2000 |
PublicationDate | 2020-01-01 |
PublicationDateYYYYMMDD | 2020-01-01 |
PublicationDate_xml | – month: 01 year: 2020 text: 2020-01-01 day: 01 |
PublicationDecade | 2020 |
PublicationTitle | Iranian journal of pediatric hematology and oncology |
PublicationYear | 2020 |
SSID | ssj0000601504 |
Score | 2.1623232 |
Snippet | Background: Nausea and vomiting are the common side-effects of chemotherapy in children with malignancy. In this study, the effectiveness of vitamin B6 in... |
SourceID | crossref |
SourceType | Aggregation Database |
Title | The effect of Vitamin B6 on chemotherapy induced nausea and vomiting in pediatric cancer |
hasFullText | 1 |
inHoldings | 1 |
isFullTextHit | |
isPrint | |
link | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwnV1Lb9NAEF6FIiEuiKeAAtoDJ5BDbe863mOKaNOiICG1KDdrn4pLY0etnUP-QP82s484bgtSyyFWvF6NLM-n3W9m54HQR7CMKVcjGumMywgYcRqJNFGRbWxtJEu0cK6B6Y9sckqOZ3Q2GFz1opbaRgzl-q95Jf-jVRgDvdos2XtothMKA_Af9AtX0DBc76xjH5BhOd8vMPMXZfV5P7MnAKCMRciusql9qnUH_by1qZHWWb6qF2UTElqWm34dNgZMhnjdwFiPYDMrg7c-MNftdFfxdVvFqa7kNS_9tG4v-aqMJvwSKChX2vlwXHzvutsOxkqfVz5kd2ybnnT-6QN-Uf-eL_TcgeqwPre3nWgY5qIMTm1Ysfm678BI9noODLfOuQiMPPct8Yb69titVT6nrmxsebac18NVvFeCoR_7YujXK2rf2Om6-ENr-VghhRNROBGFFfEAPUxGjNrY0O8_885ZZ4vWUNeKsnuxcEJupXy5-SI9jtMjKydP0ZNgZeCxh8wzNNDVc_RoGuIoXqAZIAd75ODa4IAcvJ_husJ95OCAHOyRg0HLeIMceIY7KGCPnJfo9ODbyddJFHpsRDIhtInECPiJIoamJo7hN-IqllJJxRMmUpEqKRLJBKOMUMGVYUksNDXA84kxhPD0Fdqp6kq_RjjmJDPC1suDycA8OWwfSS4F54oRwuI36NPmqxRLX0ql-Kci3t5n8i56vAXWO7TTXLT6PXDFRnxwevwDMyhuxg |
link.rule.ids | 315,786,790,27955,27956 |
linkProvider | Colorado Alliance of Research Libraries |
openUrl | ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=The+effect+of+Vitamin+B6+on+chemotherapy+induced+nausea+and+vomiting+in+pediatric+cancer&rft.jtitle=Iranian+journal+of+pediatric+hematology+and+oncology&rft.au=Mousavi-Hasanzadeh%2C+Morteza&rft.au=Adelnia%2C+Arefeh&rft.au=Farokhmehr%2C+Golrokh&rft.au=Mehrabi%2C+Sarvenaz&rft.date=2020-01-01&rft.issn=2008-8892&rft.eissn=2008-8892&rft_id=info:doi/10.18502%2Fijpho.v10i1.2164&rft.externalDBID=n%2Fa&rft.externalDocID=10_18502_ijpho_v10i1_2164 |
thumbnail_l | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=2008-8892&client=summon |
thumbnail_m | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=2008-8892&client=summon |
thumbnail_s | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=2008-8892&client=summon |