A new β-carboline alkaloid from the Streptomyces flocculus CGMCC4.1223 mutant ΔstnK4

• Published in: Tetrahedron Vol. 130; p. 133170
• Main Authors: Xiaozheng, Wang, Jing, Wo, Fei, Xu, Xinyue, Xie, Tingting, Huang, Shuangjun, Lin
• Format: Journal Article
• Language: English
• Published: Elsevier Ltd 09.01.2023
• Subjects: alkaloids; biochemical pathways; biosynthesis; genetic engineering; indoles; multigene family; mutants; spectroscopy; Streptomyces flocculus; streptonigrin; β-carboline; Streptomyces flocculus; β-carboline; streptonigrin

The β-carboline alkaloids are a large group of natural and synthetic indole alkaloids with various pharmacological properties. Previously, the gene cluster of streptonigrin biosynthesis (stn) was identified in Streptomyces flocculus CGMCC4.1223, revealing a hypothetical protein (StnK4). In this work...