A new β-carboline alkaloid from the Streptomyces flocculus CGMCC4.1223 mutant ΔstnK4
The β-carboline alkaloids are a large group of natural and synthetic indole alkaloids with various pharmacological properties. Previously, the gene cluster of streptonigrin biosynthesis (stn) was identified in Streptomyces flocculus CGMCC4.1223, revealing a hypothetical protein (StnK4). In this work...
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| Published in | Tetrahedron Vol. 130; p. 133170 |
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| Main Authors | , , , , , |
| Format | Journal Article |
| Language | English |
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09.01.2023
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| Abstract | The β-carboline alkaloids are a large group of natural and synthetic indole alkaloids with various pharmacological properties. Previously, the gene cluster of streptonigrin biosynthesis (stn) was identified in Streptomyces flocculus CGMCC4.1223, revealing a hypothetical protein (StnK4). In this work, a mutant ΔstnK4 was constructed by genetic manipulation and the mutant produced three β-carboline alkaloids, including two known compounds (oxoproopaline D and oxoproopaline G) and one new compound, namely oxoproopaline H. Structure of the new β-carboline was established by spectroscopic analyses. A biosynthetic pathway for these β-carboline alkaloids was proposed. |
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| AbstractList | The β-carboline alkaloids are a large group of natural and synthetic indole alkaloids with various pharmacological properties. Previously, the gene cluster of streptonigrin biosynthesis (stn) was identified in Streptomyces flocculus CGMCC4.1223, revealing a hypothetical protein (StnK4). In this work, a mutant ΔstnK4 was constructed by genetic manipulation and the mutant produced three β-carboline alkaloids, including two known compounds (oxoproopaline D and oxoproopaline G) and one new compound, namely oxoproopaline H. Structure of the new β-carboline was established by spectroscopic analyses. A biosynthetic pathway for these β-carboline alkaloids was proposed. |
| ArticleNumber | 133170 |
| Author | Fei, Xu Xinyue, Xie Tingting, Huang Shuangjun, Lin Jing, Wo Xiaozheng, Wang |
| Author_xml | – sequence: 1 givenname: Wang surname: Xiaozheng fullname: Xiaozheng, Wang organization: State Key Laboratory of Microbial Metabolism, Joint International Laboratory of Metabolic & Developmental Sciences, School of Life Sciences & Biotechnology, Shanghai Jiao Tong University, Shanghai, 200240, China – sequence: 2 givenname: Wo surname: Jing fullname: Jing, Wo organization: State Key Laboratory of Microbial Metabolism, Joint International Laboratory of Metabolic & Developmental Sciences, School of Life Sciences & Biotechnology, Shanghai Jiao Tong University, Shanghai, 200240, China – sequence: 3 givenname: Xu surname: Fei fullname: Fei, Xu organization: State Key Laboratory of Microbial Metabolism, Joint International Laboratory of Metabolic & Developmental Sciences, School of Life Sciences & Biotechnology, Shanghai Jiao Tong University, Shanghai, 200240, China – sequence: 4 givenname: Xie surname: Xinyue fullname: Xinyue, Xie organization: State Key Laboratory of Microbial Metabolism, Joint International Laboratory of Metabolic & Developmental Sciences, School of Life Sciences & Biotechnology, Shanghai Jiao Tong University, Shanghai, 200240, China – sequence: 5 givenname: Huang surname: Tingting fullname: Tingting, Huang organization: State Key Laboratory of Microbial Metabolism, Joint International Laboratory of Metabolic & Developmental Sciences, School of Life Sciences & Biotechnology, Shanghai Jiao Tong University, Shanghai, 200240, China – sequence: 6 givenname: Lin surname: Shuangjun fullname: Shuangjun, Lin email: linsj@sjtu.edu.cn organization: State Key Laboratory of Microbial Metabolism, Joint International Laboratory of Metabolic & Developmental Sciences, School of Life Sciences & Biotechnology, Shanghai Jiao Tong University, Shanghai, 200240, China |
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| Title | A new β-carboline alkaloid from the Streptomyces flocculus CGMCC4.1223 mutant ΔstnK4 |
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