A2A receptor agonists and P2Y12 receptor antagonists modulate expression of thrombospondin-1 (TSP-1) and its secretion from Human Microvascular Endothelial Cells (HMEC-1)

• Published in: Microvascular research Vol. 138; p. 104218
• Main Authors: Gdula, Anna M., Swiatkowska, Maria
• Format: Journal Article
• Language: English
• Published: Elsevier Inc 01.11.2021
• Subjects: A2A receptor; Dual purinoceptor-dependent approach; P2Y12 receptor; Thrombospondin-1; P2Y12 receptor; Thrombospondin-1; A2A receptor; Dual purinoceptor-dependent approach

To address the problem of resistance to standard antiplatelet therapy in some patients, our team proposed a purinoceptor-dependent dual therapy. Its efficacy is also determined by the condition of the vascular endothelium which, by secreting numerous factors, is involved in hemostasis. Among them, t...