Nitric Oxide Production and Endothelium-Dependent Vasorelaxation Ameliorated by N 1 -Methylnicotinamide in Human Blood Vessels

• Published in: Hypertension (Dallas, Tex. 1979) Vol. 59; no. 4; pp. 825 - 832
• Main Authors: Domagala, Teresa B., Szeffler, Agata, Dobrucki, Lawrence W., Dropinski, Jerzy, Polanski, Stanisław, Leszczynska-Wiloch, Magdalena, Kotula-Horowitz, Katarzyna, Wojciechowski, Jacek, Wojnowski, Leszek, Szczeklik, Andrzej, Kalinowski, Leszek
• Format: Journal Article
• Language: English
• Published: 01.04.2012

N 1 -methylnicotinamide (MNA + ) has until recently been thought to be a biologically inactive product of nicotinamide metabolism in the pyridine nucleotides pathway. However, the latest observations imply that MNA + may exert antithrombotic and anti-inflammatory effects through direct action on the...