Gastro-entero-pancreatic neuroendocrine tumors in multiple endocrine neoplasia type 1: a therapy update

Gastro-entero-pancreatic neuroendocrine tumors (GEP-NETs) are the second most common tumors in multiple endocrine neoplasia type 1 (MEN1), mainly occurring in pancreatic islets and duodenum, usually as multiple tumors. They can manifest as both nonfunctioning and functioning tumors. Currently, surgi...

Full description

Saved in:
Bibliographic Details
Published inInternational journal of endocrine oncology Vol. 4; no. 1; pp. 43 - 58
Main Authors Tonelli, Francesco, Marini, Francesca, Giusti, Francesca, Brandi, Maria Luisa
Format Journal Article
LanguageEnglish
Published London Future Medicine Ltd 01.03.2017
Subjects
Clinical trials
genetic test
GEP-NETs
Localization
Medical imaging
medical therapy
MEN1
Metastasis
Mutation
Neuroendocrine tumors
NMR
Nuclear magnetic resonance
Pancreatic cancer
Patients
Polypeptides
Proteins
surgical therapy
Tumorigenesis
Online AccessGet full text

Cover

Abstract Gastro-entero-pancreatic neuroendocrine tumors (GEP-NETs) are the second most common tumors in multiple endocrine neoplasia type 1 (MEN1), mainly occurring in pancreatic islets and duodenum, usually as multiple tumors. They can manifest as both nonfunctioning and functioning tumors. Currently, surgical removal of GEP-NETs in MEN1 represents the gold standard curative approach. Conventional medical therapies for sporadic GEP-NETs showed to be effective also in a percentage of MEN1 patients. Innovative medical therapies, that have demonstrated to be effective on sporadic GEP-NETs, still need to be evaluated on MEN1 patients in prospective clinical trials and long-term follow-up. This review resumes current knowledge of MEN1 GEP-NETs, discussing surgical and medical approaches, genetic and molecular bases of tumorigenesis, and presenting novel possible drug therapies.
AbstractList Gastro-entero-pancreatic neuroendocrine tumors (GEP-NETs) are the second most common tumors in multiple endocrine neoplasia type 1 (MEN1), mainly occurring in pancreatic islets and duodenum, usually as multiple tumors. They can manifest as both nonfunctioning and functioning tumors. Currently, surgical removal of GEP-NETs in MEN1 represents the gold standard curative approach. Conventional medical therapies for sporadic GEP-NETs showed to be effective also in a percentage of MEN1 patients. Innovative medical therapies, that have demonstrated to be effective on sporadic GEP-NETs, still need to be evaluated on MEN1 patients in prospective clinical trials and long-term follow-up. This review resumes current knowledge of MEN1 GEP-NETs, discussing surgical and medical approaches, genetic and molecular bases of tumorigenesis, and presenting novel possible drug therapies.
Author Brandi, Maria Luisa
Tonelli, Francesco
Marini, Francesca
Giusti, Francesca
AuthorAffiliation 1Department of Surgery & Translational Medicine, University of Florence, Florence, Italy
AuthorAffiliation_xml – name: 1Department of Surgery & Translational Medicine, University of Florence, Florence, Italy
Author_xml – sequence: 1
  givenname: Francesco
  surname: Tonelli
  fullname: Tonelli, Francesco
– sequence: 2
  givenname: Francesca
  surname: Marini
  fullname: Marini, Francesca
– sequence: 3
  givenname: Francesca
  surname: Giusti
  fullname: Giusti, Francesca
– sequence: 4
  givenname: Maria Luisa
  surname: Brandi
  fullname: Brandi, Maria Luisa
BookMark eNp1kMFPwyAUh4mZiXPu6J3EMwq0lM6bWXSaLPGiZ0Lpq7J0UIEe9t_LUqOJyU7v8fh-kPddopnzDhC6ZvSWcybv7A4Ip6wilDJ5huacloLQWsrZb1-tLtAyxh3NiJAFk_UcfWx0TMETcAlyGbQzAXSyBjsYgwfXehOsA5zGvQ8RW4f3Y5_s0AP-u3Tgh15Hq3E6DIDZPc7dJwQ9HPA4tDrBFTrvdB9h-VMX6P3p8W39TLavm5f1w5YYXopE2EqbsgJeli1tG6BN0xSiNhKKpqyrPGEUjDSCa80rxoxooK047TrRtWVtRLFAN9O7Q_BfI8Skdn4MLn-psqZKlLySdaaKiTLBxxigU8amvLV3KWjbK0aPtFRZqjpKVUepOUX-pYZg9zocTvKrie_GNAaIxoIzoKbTHlprsrsT2W_Cz5DS
CitedBy_id crossref_primary_10_1080_21678707_2020_1811086
Cites_doi 10.1530/EJE-11-0929
10.3748/wjg.v19.i45.8312
10.1200/JCO.2008.21.5988
10.1016/S0002-9440(10)61788-9
10.1016/j.ecl.2010.12.006
10.1210/jc.2012-1230
10.1530/EJE-14-0130
10.1002/humu.20605
10.1007/s00280-012-2055-z
10.1111/j.1365-2036.2009.04174.x
10.4251/wjgo.v8.i4.389
10.1159/000443167
10.1210/jc.2002-021314
10.1111/j.1365-2265.2008.03324.x
10.1007/s00259-013-2677-3
10.1016/j.beem.2015.09.004
10.1002/humu.21170
10.1111/jcmm.12552
10.1111/j.1365-2036.2011.04693.x
10.1136/bmjopen-2015-010765
10.1007/0-387-29512-7_7
10.1097/MD.0b013e3182954af1
10.1056/NEJMoa1316158
10.1210/jcem.86.12.8070
10.1073/pnas.0603877103
10.1016/B978-1-4160-5583-9.00150-7
10.1016/j.beem.2010.01.001
10.1136/gutjnl-2011-300831
10.1073/pnas.90.23.10914
10.1038/modpathol.2012.53
10.1016/j.beem.2015.10.005
10.1056/NEJMoa1003825
10.1111/cen.12411
10.1093/hmg/6.13.2285
10.1371/journal.pone.0039767
10.1007/s00428-007-0450-3
10.1210/jc.2008-2083
10.1016/S2213-8587(15)00043-1
10.1053/j.gastro.2013.10.020
10.1002/humu.21354
10.1530/EJE-14-0080
10.1200/JCO.2007.15.2553
10.1200/JCO.2004.04.024
10.1007/s00268-005-0354-9
10.1200/JCO.2009.22.8510
10.1016/j.ecl.2010.12.003
10.3109/02841868909111211
10.1371/journal.pgen.1003350
10.1056/NEJMc1406028
10.1002/cncr.25425
10.1007/s00259-014-2893-5
10.1128/MCB.24.15.6569-6580.2004
10.1152/ajpendo.00542.2013
10.1007/s00268-006-0360-y
10.1016/j.critrevonc.2015.11.003
10.1200/JCO.2005.08.066
10.1007/s00259-007-0691-z
10.1093/jnci/djs208
10.1056/NEJMoa1009290
10.1016/j.cancergen.2015.12.002
10.1038/modpathol.2010.58
10.5754/hge11212
10.1038/ng0897-375
10.1001/archderm.1997.03890430067009
10.1093/annonc/mdh216
ContentType Journal Article
Copyright Future Medicine Ltd
2017. This work is published under http://creativecommons.org/licenses/by-nc-nd/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.
Copyright_xml – notice: Future Medicine Ltd
– notice: 2017. This work is published under http://creativecommons.org/licenses/by-nc-nd/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.
DBID AAYXX
CITATION
3V.
7X7
7XB
8FI
8FJ
8FK
ABUWG
AFKRA
AZQEC
BENPR
CCPQU
DWQXO
FYUFA
GHDGH
K9.
M0S
PHGZM
PHGZT
PIMPY
PKEHL
PQEST
PQQKQ
PQUKI
DOI 10.2217/ije-2016-0017
DatabaseName CrossRef
ProQuest Central (Corporate)
Health & Medical Collection
ProQuest Central (purchase pre-March 2016)
Hospital Premium Collection
Hospital Premium Collection (Alumni Edition)
ProQuest Central (Alumni) (purchase pre-March 2016)
ProQuest Central (Alumni)
ProQuest Central UK/Ireland
ProQuest Central Essentials
ProQuest Central
ProQuest One Community College
ProQuest Central Korea
Health Research Premium Collection
Health Research Premium Collection (Alumni)
ProQuest Health & Medical Complete (Alumni)
ProQuest Health & Medical Collection
ProQuest Central Premium
ProQuest One Academic
Publicly Available Content Database
ProQuest One Academic Middle East (New)
ProQuest One Academic Eastern Edition (DO NOT USE)
ProQuest One Academic
ProQuest One Academic UKI Edition
DatabaseTitle CrossRef
Publicly Available Content Database
ProQuest One Academic Middle East (New)
ProQuest Central Essentials
ProQuest One Academic Eastern Edition
ProQuest Health & Medical Complete (Alumni)
ProQuest Central (Alumni Edition)
ProQuest One Community College
ProQuest Hospital Collection
Health Research Premium Collection (Alumni)
ProQuest Hospital Collection (Alumni)
ProQuest Central
ProQuest Health & Medical Complete
Health Research Premium Collection
ProQuest One Academic UKI Edition
Health and Medicine Complete (Alumni Edition)
ProQuest Central Korea
ProQuest Central (New)
ProQuest One Academic
ProQuest One Academic (New)
ProQuest Central (Alumni)
DatabaseTitleList Publicly Available Content Database
Database_xml – sequence: 1
  dbid: 7X7
  name: Health & Medical Collection
  url: https://search.proquest.com/healthcomplete
  sourceTypes: Aggregation Database
DeliveryMethod fulltext_linktorsrc
Discipline Medicine
EISSN 2045-0877
EndPage 58
ExternalDocumentID 10_2217_ije_2016_0017
GroupedDBID 3V.
7X7
8FI
8FJ
ABUWG
ACGFS
ADBBV
AFKRA
ALMA_UNASSIGNED_HOLDINGS
BBAFP
BENPR
BPHCQ
BVXVI
EBS
EJD
FYUFA
H13
MV1
NTCAX
PIMPY
PQEST
PQQKQ
PROAC
RFM
0YH
4.4
AAYXX
ABJNI
AGFEN
ALIPV
BCNDV
CCPQU
CITATION
HMCUK
OK1
PHGZM
PHGZT
TDBHL
TFMDE
TMEDX
UKHRP
7XB
8FK
AZQEC
DWQXO
K9.
PKEHL
PQUKI
ID FETCH-LOGICAL-c245t-19ac46e244d0dbe0bbb358c7e3b486dbe10ec7c52aa2611c5bed620ff5fd48c53
IEDL.DBID 7X7
ISSN 2045-0869
IngestDate Sun Jun 29 16:10:34 EDT 2025
Thu Apr 24 22:56:57 EDT 2025
Tue Jul 01 01:27:20 EDT 2025
Tue Jan 05 21:42:19 EST 2021
IsDoiOpenAccess true
IsOpenAccess true
IsPeerReviewed true
IsScholarly true
Issue 1
Language English
LinkModel DirectLink
MergedId FETCHMERGED-LOGICAL-c245t-19ac46e244d0dbe0bbb358c7e3b486dbe10ec7c52aa2611c5bed620ff5fd48c53
Notes ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 14
OpenAccessLink https://www.proquest.com/docview/2216542678?pq-origsite=%requestingapplication%
PQID 2216542678
PQPubID 3747997
PageCount 16
ParticipantIDs proquest_journals_2216542678
crossref_citationtrail_10_2217_ije_2016_0017
crossref_primary_10_2217_ije_2016_0017
futurescience_futuremedicine_10_2217_ije_2016_0017
ProviderPackageCode RFM
NTCAX
CITATION
AAYXX
PublicationCentury 2000
PublicationDate 2017-March-01
2017-03-00
20170301
PublicationDateYYYYMMDD 2017-03-01
PublicationDate_xml – month: 03
  year: 2017
  text: 2017-March-01
  day: 01
PublicationDecade 2010
PublicationPlace London
PublicationPlace_xml – name: London
PublicationTitle International journal of endocrine oncology
PublicationYear 2017
Publisher Future Medicine Ltd
Publisher_xml – name: Future Medicine Ltd
References e_1_3_2_28_1
e_1_3_2_49_1
e_1_3_2_20_1
e_1_3_2_41_1
e_1_3_2_66_1
e_1_3_2_22_1
e_1_3_2_43_1
Bordi C (e_1_3_2_52_1) 1995; 19
e_1_3_2_64_1
e_1_3_2_24_1
e_1_3_2_45_1
e_1_3_2_26_1
e_1_3_2_47_1
e_1_3_2_68_1
e_1_3_2_60_1
Tonelli F (e_1_3_2_46_1) 2016
e_1_3_2_16_1
e_1_3_2_39_1
e_1_3_2_9_1
e_1_3_2_7_1
Edge SB (e_1_3_2_10_1) 2010
e_1_3_2_31_1
e_1_3_2_54_1
e_1_3_2_33_1
e_1_3_2_75_1
e_1_3_2_12_1
e_1_3_2_35_1
e_1_3_2_58_1
e_1_3_2_5_1
e_1_3_2_14_1
e_1_3_2_37_1
e_1_3_2_56_1
e_1_3_2_3_1
Saif MW (e_1_3_2_44_1) 2013; 14
e_1_3_2_50_1
e_1_3_2_73_1
e_1_3_2_71_1
e_1_3_2_27_1
e_1_3_2_29_1
e_1_3_2_42_1
e_1_3_2_65_1
e_1_3_2_21_1
e_1_3_2_63_1
Zhuang Z (e_1_3_2_18_1) 1997; 57
e_1_3_2_23_1
e_1_3_2_69_1
e_1_3_2_25_1
e_1_3_2_48_1
e_1_3_2_67_1
e_1_3_2_61_1
e_1_3_2_40_1
e_1_3_2_17_1
e_1_3_2_38_1
e_1_3_2_8_1
Bosman F (e_1_3_2_11_1) 2010
Hessman O (e_1_3_2_19_1) 1998; 58
e_1_3_2_30_1
e_1_3_2_55_1
e_1_3_2_76_1
e_1_3_2_32_1
e_1_3_2_53_1
e_1_3_2_74_1
e_1_3_2_6_1
e_1_3_2_13_1
e_1_3_2_34_1
e_1_3_2_59_1
e_1_3_2_4_1
e_1_3_2_15_1
e_1_3_2_36_1
e_1_3_2_57_1
e_1_3_2_51_1
e_1_3_2_72_1
e_1_3_2_70_1
Qureshi SA (e_1_3_2_62_1) 2015; 46
References_xml – ident: e_1_3_2_27_1
  doi: 10.1530/EJE-11-0929
– ident: e_1_3_2_49_1
  doi: 10.3748/wjg.v19.i45.8312
– ident: e_1_3_2_73_1
  doi: 10.1200/JCO.2008.21.5988
– year: 2016
  ident: e_1_3_2_46_1
  article-title: Surgery for insulinomas in multiple endocrine neoplasia type 1: when pancreatoduodenectomy is appropriate
  publication-title: Surgery
– volume: 58
  start-page: 377
  issue: 3
  year: 1998
  ident: e_1_3_2_19_1
  article-title: Mutation of the multiple endocrine neoplasia type 1 gene in nonfamilial, malignant tumours of the endocrine pancreas
  publication-title: Cancer. Res.
– ident: e_1_3_2_5_1
  doi: 10.1016/S0002-9440(10)61788-9
– volume: 14
  start-page: 498
  issue: 5
  year: 2013
  ident: e_1_3_2_44_1
  article-title: A retrospective study of capecitabine/temozolomide (CAPTEM) regimen in the treatment of metastatic pancreatic neuroendocrine tumours (pNETs) after failing previous therapy
  publication-title: JOP
– ident: e_1_3_2_67_1
  doi: 10.1016/j.ecl.2010.12.006
– ident: e_1_3_2_8_1
  doi: 10.1210/jc.2012-1230
– ident: e_1_3_2_33_1
  doi: 10.1530/EJE-14-0130
– ident: e_1_3_2_22_1
  doi: 10.1002/humu.20605
– ident: e_1_3_2_43_1
  doi: 10.1007/s00280-012-2055-z
– ident: e_1_3_2_50_1
  doi: 10.1111/j.1365-2036.2009.04174.x
– ident: e_1_3_2_53_1
  doi: 10.4251/wjgo.v8.i4.389
– ident: e_1_3_2_58_1
  doi: 10.1159/000443167
– ident: e_1_3_2_51_1
  doi: 10.1210/jc.2002-021314
– ident: e_1_3_2_15_1
  doi: 10.1111/j.1365-2265.2008.03324.x
– ident: e_1_3_2_65_1
  doi: 10.1007/s00259-013-2677-3
– ident: e_1_3_2_47_1
  doi: 10.1016/j.beem.2015.09.004
– ident: e_1_3_2_25_1
  doi: 10.1002/humu.21170
– volume: 19
  start-page: 175
  issue: 1
  year: 1995
  ident: e_1_3_2_52_1
  article-title: Hypergastrinemia and gastric entrocromaffin-like cells
  publication-title: Am. J. Surg. Pathol.
– ident: e_1_3_2_34_1
  doi: 10.1111/jcmm.12552
– ident: e_1_3_2_59_1
  doi: 10.1111/j.1365-2036.2011.04693.x
– volume: 46
  start-page: e010765
  issue: 5
  year: 2015
  ident: e_1_3_2_62_1
  article-title: Screening for malnutrition in patients with gastro-entero-pancreatic neuroendocrine tumours: a cross-sectional study
  publication-title: BMJ Open
  doi: 10.1136/bmjopen-2015-010765
– ident: e_1_3_2_64_1
  doi: 10.1007/0-387-29512-7_7
– volume-title: AJCC Cancer Staging Manual
  year: 2010
  ident: e_1_3_2_10_1
– ident: e_1_3_2_14_1
  doi: 10.1097/MD.0b013e3182954af1
– ident: e_1_3_2_55_1
  doi: 10.1056/NEJMoa1316158
– ident: e_1_3_2_60_1
  doi: 10.1056/NEJMoa1316158
– ident: e_1_3_2_3_1
  doi: 10.1210/jcem.86.12.8070
– ident: e_1_3_2_31_1
  doi: 10.1073/pnas.0603877103
– ident: e_1_3_2_48_1
  doi: 10.1016/B978-1-4160-5583-9.00150-7
– ident: e_1_3_2_32_1
  doi: 10.1016/j.beem.2010.01.001
– ident: e_1_3_2_45_1
  doi: 10.1136/gutjnl-2011-300831
– ident: e_1_3_2_17_1
  doi: 10.1073/pnas.90.23.10914
– ident: e_1_3_2_37_1
  doi: 10.1038/modpathol.2012.53
– ident: e_1_3_2_69_1
  doi: 10.1016/j.beem.2015.10.005
– ident: e_1_3_2_76_1
  doi: 10.1056/NEJMoa1003825
– ident: e_1_3_2_57_1
  doi: 10.1111/cen.12411
– ident: e_1_3_2_21_1
  doi: 10.1093/hmg/6.13.2285
– ident: e_1_3_2_35_1
  doi: 10.1371/journal.pone.0039767
– ident: e_1_3_2_9_1
  doi: 10.1007/s00428-007-0450-3
– ident: e_1_3_2_30_1
  doi: 10.1210/jc.2008-2083
– ident: e_1_3_2_16_1
  doi: 10.1016/S2213-8587(15)00043-1
– ident: e_1_3_2_38_1
  doi: 10.1053/j.gastro.2013.10.020
– ident: e_1_3_2_26_1
  doi: 10.1002/humu.21354
– ident: e_1_3_2_29_1
  doi: 10.1530/EJE-14-0080
– ident: e_1_3_2_66_1
  doi: 10.1200/JCO.2007.15.2553
– ident: e_1_3_2_41_1
  doi: 10.1200/JCO.2004.04.024
– ident: e_1_3_2_63_1
– ident: e_1_3_2_39_1
  doi: 10.1007/s00268-005-0354-9
– ident: e_1_3_2_56_1
  doi: 10.1200/JCO.2009.22.8510
– ident: e_1_3_2_68_1
  doi: 10.1016/j.ecl.2010.12.003
– volume: 57
  start-page: 4682
  issue: 21
  year: 1997
  ident: e_1_3_2_18_1
  article-title: Somatic mutations of the MEN1 tumour suppressor gene in sporadic gastrinomas and insulinomas
  publication-title: Cancer Res.
– volume-title: WHO Classification of Tumours of the Digestive System
  year: 2010
  ident: e_1_3_2_11_1
– ident: e_1_3_2_7_1
  doi: 10.3109/02841868909111211
– ident: e_1_3_2_28_1
  doi: 10.1371/journal.pgen.1003350
– ident: e_1_3_2_6_1
  doi: 10.1056/NEJMc1406028
– ident: e_1_3_2_42_1
  doi: 10.1002/cncr.25425
– ident: e_1_3_2_72_1
  doi: 10.1007/s00259-014-2893-5
– ident: e_1_3_2_24_1
  doi: 10.1128/MCB.24.15.6569-6580.2004
– ident: e_1_3_2_36_1
  doi: 10.1152/ajpendo.00542.2013
– ident: e_1_3_2_40_1
  doi: 10.1007/s00268-006-0360-y
– ident: e_1_3_2_54_1
  doi: 10.1016/j.critrevonc.2015.11.003
– ident: e_1_3_2_71_1
  doi: 10.1200/JCO.2005.08.066
– ident: e_1_3_2_70_1
  doi: 10.1007/s00259-007-0691-z
– ident: e_1_3_2_12_1
  doi: 10.1093/jnci/djs208
– ident: e_1_3_2_75_1
  doi: 10.1056/NEJMoa1009290
– ident: e_1_3_2_23_1
  doi: 10.1016/j.cancergen.2015.12.002
– ident: e_1_3_2_13_1
  doi: 10.1038/modpathol.2010.58
– ident: e_1_3_2_74_1
  doi: 10.5754/hge11212
– ident: e_1_3_2_20_1
  doi: 10.1038/ng0897-375
– ident: e_1_3_2_4_1
  doi: 10.1001/archderm.1997.03890430067009
– ident: e_1_3_2_61_1
  doi: 10.1093/annonc/mdh216
SSID ssj0001573178
Score 1.9898605
Snippet Gastro-entero-pancreatic neuroendocrine tumors (GEP-NETs) are the second most common tumors in multiple endocrine neoplasia type 1 (MEN1), mainly occurring in...
SourceID proquest
crossref
futurescience
SourceType Aggregation Database
Enrichment Source
Index Database
Publisher
StartPage 43
SubjectTerms Clinical trials
genetic test
GEP-NETs
Localization
Medical imaging
medical therapy
MEN1
Metastasis
Mutation
Neuroendocrine tumors
NMR
Nuclear magnetic resonance
Pancreatic cancer
Patients
Polypeptides
Proteins
surgical therapy
Tumorigenesis
Title Gastro-entero-pancreatic neuroendocrine tumors in multiple endocrine neoplasia type 1: a therapy update
URI http://dx.doi.org/10.2217/ije-2016-0017
https://www.proquest.com/docview/2216542678
Volume 4
hasFullText 1
inHoldings 1
isFullTextHit
isPrint
link http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwfV3dS8MwEA-6gQgifuJ0jjyIT4a16bcvorI5hA0RB3srSZrJRNu5dv-_d21qEdGnfqQt9C65r9z9jpALUMJyzq2AuTLUzI24YEL7gkkhuAJJKRIb653HE380dR9n3swE3HKTVlnLxFJQJ5nCGHmfc6y74SBbb5afDLtG4e6qaaGxSdoIXYazOpgFTYzFC0A9lk3pwHJhYL1HFcwmfCzoL940zBEbHGqrbFfWqKWdCs_D6KBfUrpUPcM9smtsRnpbMXmfbOj0gGyNza74IXl9EHmxyhjCa8IB1ndlCipaolXqFP4Oi_xosf7IVjldpLTOI6TNYIq55FhTSTEsS-1rCmcV5gBdLzEwcESmw8HL_YiZBgpMcdcrmB0J5foaNHhiJVJbUkrHC1WgHemGPtyxLa0C5XFgjG_bypM68bk1n3vzxA2V5xyTVpql-oRQ8KF1JHHTFhZwAj4beGqWkA6YM6ELRl-HXNX0i5VBF8cmF-8xeBlI7hjIHSO5MYsu6JDL78eXFazGXw_yH8yIq6s68eCvl7o1x2KzJPO4mUCn_w-fkW2OurtMNOuSVrFa63OwPArZK6dXj7TvBpOn5y9289oM
linkProvider ProQuest
linkToHtml http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwtV1ZSwMxEA6lggoinlitmgf1ydDddK8KIuLV2uOphb6tSTYrFd3Wdov4p_yNzuxhEalvfdojuxAmwzfzJXMQcgJGWIbccJklPc2sGhdMaEcwKQRXgJQiMDHfud1x6j3rsW_3C-Qrz4XBsMocExOgDoYK98grnGPeDQdsvRq9M-wahaereQuNVC2a-vMDKNvksnEL63vK-f1d96bOsq4CTHHLjplZE8pyNJi1wAikNqSUVdtTrq5Ky3PgjWlo5Sqbw2wd01S21IHDjTC0w8DyFHaJAMhfAsNrINlz--5sT8d2wRwnTfDAU2LAFmppWU-YvFsZvGjQSRMIvJG0R5uZwbW0fkhm8_5YhcTU3W-Q9cxHpdepUm2Sgo62yHI7O4XfJs8PYhKPhwzLecIF8CR1PRVNqmPqCKSJSYU0nr4NxxM6iGget0hngxHGrmMOJ8VtYGpeULhLaxzQ6Qg3InZIbyGi3SXFaBjpPUKBs-uaxENiAIwAOCIwQ0PIKrhPngVOZomc5_LzVVbNHJtqvPrAalDcPojbR3Fj1J5bImc_n4_SMh7zPuS_FsNPn_JAh3k_lfMV8zMImPgzhd3_f_iYrNS77ZbfanSaB2SVo9-QBLmVSTEeT_UheD2xPEpUjZKnRev2N0ZQFy4
linkToPdf http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwtV1ZS8NAEB6khSKIeGI990F9cmmyzVVBxKveRUTBt7i72YiiaW1TxL_mr3Mmh0VE33zKsQkks8M38-3OAbCORljFwvK5owLDnZaQXBpPciWl0IiUMrIp3_my453cOmd37t0YfJS5MBRWWWJiBtRRV9MaeUMIyrsRiK2NuAiLuDps7_ZeOXWQop3Wsp1GriLn5v0N6dtg5_QQ53pDiPbRzcEJLzoMcC0cN-V2S2rHM2jiIitSxlJKNd1A-6apnMDDO7ZltK9dgV_u2bZ2lYk8YcWxG0dOoKljBMJ_1SdWVIHq_lHn6nq0wuP6aJyzlnjoN3HkDq28yCf-it94fDKooTbSeStrljYyihN5NZHCAv6wEZnha0_BZOGxsr1cxaZhzCQzULss9uRn4eFYDtJ-l1NxTzwguuSOqGZZrUyToGwpxZClw5duf8AeE1ZGMbLRYEKR7JTRyWhRmNnbDM_yigds2KNliTm4_RfhzkMl6SZmARgyeNNStGWM8BEhY0SeaEnVRGcqcNDlrMNWKb9QF7XNqcXGc4gch8QdorhDEjfF8Pl12Px6vJcX9fjtQfFtMsL8qgx7-O2l5XLGwgIQBuFIfRf_Hl6DGup1eHHaOV-CcUFORBbxtgyVtD80K-gCpWq10DUG9_-t3p_IehzJ
openUrl ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=Gastro-Entero-Pancreatic+Neuroendocrine+Tumors+in+Multiple+Endocrine+Neoplasia+Type+1%3A+A+Therapy+Update&rft.jtitle=International+journal+of+endocrine+oncology&rft.au=Tonelli%2C+Francesco&rft.au=Marini%2C+Francesca&rft.au=Giusti%2C+Francesca&rft.au=Brandi%2C+Maria+Luisa&rft.date=2017-03-01&rft.issn=2045-0869&rft.eissn=2045-0877&rft.volume=4&rft.issue=1&rft.spage=43&rft.epage=58&rft_id=info:doi/10.2217%2Fije-2016-0017&rft.externalDBID=n%2Fa&rft.externalDocID=10_2217_ije_2016_0017
thumbnail_l http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=2045-0869&client=summon
thumbnail_m http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=2045-0869&client=summon
thumbnail_s http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=2045-0869&client=summon