Efficacy of Antidopaminergic Pharmacotherapy in Pediatric Autoimmune Neuropsychiatric Disorders Associated With Streptococcal Infections (PANDAS): A Case Report

• Published in: Curēus (Palo Alto, CA) Vol. 15; no. 8
• Main Authors: Hefelfinger, Donald, Kaufman, Hannah, Gilman, Alex, Gebhart, Rick
• Format: Journal Article
• Language: English
• Published: Palo Alto Cureus Inc 26.08.2023; Cureus
• Subjects: Antibiotics; Antibodies; Behavior; Biomarkers; Case reports; Dopamine; Drug therapy; Family/General Practice; Fever; Kinases; Medical diagnosis; Obsessive compulsive disorder; Pathophysiology; Patients; Pediatrics; Primary care; Psychiatry; Psychotherapy; Streptococcus infections; Throat surgery
• ISSN: 2168-8184; 2168-8184
• DOI: 10.7759/cureus.44164

PANDAS, or pediatric autoimmune neuropsychiatric disorders associated with streptococcal infections, is a neuropsychiatric disease seen in children that presents with prevailing symptoms of obsessive-compulsive disorder (OCD), tic disorder, or both. These symptoms appear suddenly following a streptococcal infection, such as strep throat or scarlet fever. The antibodies formed to eradicate the streptococcal infection have been shown to alter central dopamine signaling. In spite of being acknowledged in the medical community for the last two to three decades, PANDAS is a disorder that goes unnoticed by many healthcare professionals. Unfortunately, even with correct diagnosis and utilization of commonly prescribed pharmacotherapy and psychotherapy, medical management can often be ineffective at treating the neuropsychiatric symptoms.Here, we describe a case of a 15-year-old male who presented to the primary care office with complaints of episodic behavioral changes that would occur multiple times daily. The general symptoms were centered around body dysmorphia where the patient became obsessed with fixed portions of food and became highly focused on only specific food types. The symptoms would exacerbate and progress with a dire need to burn calories, leading the patient to damage carpeted areas in the home due to regular and fanatical pacing. The patient underwent trials with serotonergic pharmacotherapy with little to no relief of the psychiatric symptoms. After discussion with his primary care physician, the patient underwent trial management with antidopaminergic therapy that resulted in significant neurological and psychiatric improvement. The use of antidopaminergic pharmacotherapy to target the induction of D1 and D2 dopamine receptors was efficacious in this patient; however, it warrants additional research with a larger sample to determine its effectiveness in the treatment of this psychiatric condition.