An Association of UDP-Glucuronosyltransferase 2B7 C802T (His268Tyr) Polymorphism with Bladder Cancer in Benzidine-Exposed Workers in China

• Published in: Toxicological sciences Vol. 85; no. 1; pp. 502 - 506
• Main Authors: Lin, Guo-fang, Guo, Wei-chao, Chen, Ji-gang, Qin, Yi-qing, Golka, Klaus, Xiang, Cui-qing, Ma, Qing-wen, Lu, Da-ru, Shen, Jian-hua
• Format: Journal Article
• Language: English
• Published: United States Oxford University Press 01.05.2005
• Subjects: aromatic amines; Asian Continental Ancestry Group - genetics; Benzidines - toxicity; Carcinoma, Transitional Cell - chemically induced; Carcinoma, Transitional Cell - enzymology; Carcinoma, Transitional Cell - genetics; Chemical Industry; China; Chinese; Cohort Studies; Female; Gene Frequency; Genetic Predisposition to Disease; glucuronidation; Glucuronosyltransferase - genetics; Homozygote; Humans; Male; Occupational Exposure - adverse effects; Polymorphism, Genetic; transitional cell carcinoma; Urinary Bladder Neoplasms - chemically induced; Urinary Bladder Neoplasms - enzymology; Urinary Bladder Neoplasms - genetics; China

UDP-Glucuronyltransferase 2B7 (UGT2B7) is involved in benzidine metabolism, as demonstrated by in vitro experiments with liver slices. To evaluate the possible association of UGT2B7 gene polymorphism with bladder cancer risk for benzidine-exposed subjects, diagnosed bladder cancer cases (n = 36) who...