Runx2 alleviates high glucose‐suppressed osteogenic differentiation via PI3K/AKT/GSK3β/β‐catenin pathway

• Published in: Cell biology international Vol. 41; no. 8; pp. 822 - 832
• Main Authors: Chen, Yang, Hu, Yun, Yang, Lan, Zhou, Jie, Tang, Yuying, Zheng, Leilei, Qin, Pu
• Format: Journal Article
• Language: English
• Published: England 01.08.2017
• Subjects: Alkaline Phosphatase - metabolism; Animals; beta Catenin - metabolism; Calcification, Physiologic; Cell Differentiation - physiology; Core Binding Factor Alpha 1 Subunit - metabolism; Glucose - administration & dosage; Glucose - metabolism; Glycogen Synthase Kinase 3 beta - metabolism; GSK3β/β‐catenin; high glucose; Mesenchymal Stromal Cells - cytology; Mesenchymal Stromal Cells - metabolism; Osteoblasts - cytology; Osteoblasts - metabolism; osteogenesis; Osteogenesis - physiology; Phosphatidylinositol 3-Kinases - metabolism; PI3K/AKT; Proto-Oncogene Proteins c-akt - metabolism; Rats; Rats, Sprague-Dawley; Runx2; Signal Transduction; GSK3β/β-catenin; osteogenesis; high glucose; PI3K/AKT; Runx2

Hyperglycemia is one of the most important pathogenesis of diabetic osteopathy. Several lines of studies indicate Runx2 plays a critical role in the process of osteogenic differentiation. However, little studies have analyzed the effect of Runx2 on osteoblast differentiation of rat bone mesenchymal...