Repeated administration of phytocannabinoid Δ9-THC or synthetic cannabinoids JWH-018 and JWH-073 induces tolerance to hypothermia but not locomotor suppression in mice, and reduces CB1 receptor expression and function in a brain region-specific manner

• Published in: Pharmacological research Vol. 102; pp. 22 - 32
• Main Authors: Tai, S., Hyatt, W.S., Gu, C., Franks, L.N., Vasiljevik, T., Brents, L.K., Prather, P.L., Fantegrossi, W.E.
• Format: Journal Article
• Language: English
• Published: Elsevier Ltd 01.12.2015
• Subjects: Cannabinoid; CB1R; Cross-tolerance; Desensitization; Downregulation; Tolerance; 9-THC; Desensitization; Cross-tolerance; Tolerance; AM-2201; JWH-018; Cannabinoid; HU-210; WIN-55,212-2; JWH-073; CP-55,940; Downregulation; CB1Rs; CP-47,497; [35S]GTPγS; CB1R

[Display omitted] These studies probed the relationship between intrinsic efficacy and tolerance/cross-tolerance between ∆9-THC and synthetic cannabinoid drugs of abuse (SCBs) by examining in vivo effects and cellular changes concomitant with their repeated administration in mice. Dose-effect relati...