Transforming growth factor beta-1 An important biomarker for developing cardiovascular diseases in chronic renal failure

• Published in: Bratislavské lékarské listy Vol. 118; no. 3; pp. 175 - 178
• Main Authors: Avci, E, Avci, G Alp, Ozcelik, B, Cevher, S Coskun, Suicmez, M
• Format: Journal Article
• Language: English
• Published: Slovakia 2017
• Subjects: Biomarkers; Cardiovascular Diseases - blood; Cardiovascular Diseases - epidemiology; Case-Control Studies; Humans; Immunoenzyme Techniques; Kidney Failure, Chronic - blood; Kidney Failure, Chronic - therapy; Renal Dialysis; Transforming Growth Factor beta1 - blood; Treatment Outcome; cardiovascular disease; hemodialysis transforming growth factor beta; chronic kidney disease
• DOI: 10.4149/BLL_2017_035
• ISSN: 0006-9248

Our study focuses on the determination and evaluation of TGF-β1 levels of patients receiving hemodialysis treatment because of chronic renal failure. Chronic renal failure, characterized by irreversible loss of renal function, is a major public health problem in the world. Transforming growth factor-beta is a multifunctional cytokine involved in the cellular growth, differentiation, migration, apoptosis and immune regulation. Among the three TGF-β isoforms, TGF-β1 plays a key role in the pathogenesis of renal diseases. We studied 24 patients who were on regular hemodialysis, with non-diabetic nephropathy. 20 healthy people who proved to be in a good state of health and free from any signs of chronic diseases or disorders were enrolled as a control group. Serum samples were collected both before and after hemodialysis treatment from each patient. TGF-β1 levels were determined by Enzyme Immunoassay method. TGF-β1 levels were found significantly higher in the hemodialysis patients than those of the control groups. Also, the TGF-β1 was significantly reduced after hemodialysis treatment but it was still higher than in control groups. This result indicates that hemodialysis is an effective treatment method to decrease the serum TGF-B1 levels. Nevertheless, this decrease is not enough to reduce existing risks (Tab. 1, Fig. 2, Ref. 28).