Microwave‐Assisted Synthesis of Porous Biomolecule‐Incorporated Metal‐Organic Frameworks as Efficient Nanocarriers for Anti‐Cancer Drugs

• Published in: ChemistrySelect (Weinheim) Vol. 8; no. 25
• Main Authors: Nguyen, Trang Thi Thu, Le, Bao Quang Gia, Nguyen, Vy Tran Hanh, Lee, Jae‐Hyoung, Mai, Ngoc Xuan Dat, Nguyen, Linh Ho Thuy, Doan, Tan Le Hoang
• Format: Journal Article
• Language: English
• Published: 07.07.2023
• Subjects: biomolecule incorporation; drug delivery; metal-organic frameworks; microwave; paclitaxel
• ISSN: 2365-6549; 2365-6549
• DOI: 10.1002/slct.202301543

Biomolecule‐incorporated metal‐organic frameworks (b‐MOFs) exhibit enhanced bioavailability and biocompatibility, making them an ideal option for use as drug delivery vehicles. While b‐MOFs possess outstanding drug loading and release capabilities, their microscale crystal sizes restrict their applicability as nanocarriers and drug delivery systems. To overcome this limitation, this paper presents a microwave‐irradiation‐based technique for the synthesis of porous adenine‐incorporated Zn‐based MOFs with particle sizes of approximately 200 nm as paclitaxel nanocarriers. The nanomaterial demonstrated a substantial paclitaxel loading capacity of 637 mg g−1. Moreover, it effectively increased the solubility of paclitaxel by 2.5‐fold compared to that of the free form. Thus, the nano MOF is a promising delivery vehicle for paclitaxel. Notably, the paclitaxel‐loaded nano MOF exhibited higher toxicity toward cancer cells than the free drug, further highlighting its potential as an effective anticancer agent. We demonstrate synthesis of nano porous biomolecule‐incorporated metal‐organic frameworks (b‐MOF) under microwave irradiation and strategy for using the MOF as anticancer drug delivery vehicle. The MOF showed good performance in paclitaxel (PTX) loading up to 637 mg g−1. The release profiles of PTX‐loaded b‐MOFs displayed an increase in PTX solubility with a gradual release over time. Besides, the paclitaxel‐loaded nano MOF exhibited higher toxicity toward cancer cells than the free drug, indicating its potential as an effective anticancer nanocarrier.