Functional Characterization of the m 6 A-Dependent Translational Modulator PfYTH.2 in the Human Malaria Parasite

• Published in: mBio Vol. 12; no. 2; pp. e00661 - 21
• Main Authors: Sinha, Ameya, Baumgarten, Sebastian, Distiller, Amy, McHugh, Emma, Chen, Patty, Singh, Meetali, Bryant, Jessica M., Liang, Jiaqi, Cecere, Germano, Dedon, Peter C., Preiser, Peter R., Ralph, Stuart A., Scherf, Artur
• Format: Journal Article
• Language: English
• Published: United States American Society for Microbiology 27.04.2021
• Subjects: Life Sciences; Microbiology and Parasitology; PfYTH; Plasmodium falciparum; malaria parasite; translational repression; m6A mRNA methylation
• ISSN: 2150-7511; 2161-2129; 2150-7511
• DOI: 10.1128/mBio.00661-21

Infection with the unicellular eukaryotic pathogen Plasmodium falciparum causes malaria, a mosquito-borne disease affecting more than 200 million and killing 400,000 people each year. Underlying the asexual replication within human red blood cells is a tight regulatory network of gene expression and...