Latrophilins Function as Heterophilic Cell-adhesion Molecules by Binding to Teneurins

• Published in: The Journal of biological chemistry Vol. 289; no. 1; pp. 387 - 402
• Main Authors: Boucard, Antony A., Maxeiner, Stephan, Südhof, Thomas C.
• Format: Journal Article
• Language: English
• Published: Elsevier Inc 01.01.2014
• Subjects: Alternative Splicing; Cell Adhesion; FLRT3; G Protein-coupled Receptors (GPCR); Ligand-binding Protein; Neurexin; Neurons; Synapse Formation; Teneurin; α-Latrotoxin; α-Latrotoxin; Ligand-binding Protein; Synapse Formation; G Protein-coupled Receptors (GPCR); Neurexin; Alternative Splicing; Neurons; FLRT3; Teneurin; Cell Adhesion

Latrophilin-1, -2, and -3 are adhesion-type G protein-coupled receptors that are auxiliary α-latrotoxin receptors, suggesting that they may have a synaptic function. Using pulldowns, we here identify teneurins, type II transmembrane proteins that are also candidate synaptic cell-adhesion molecules,...