Pericellular Versican Regulates the Fibroblast-Myofibroblast Transition

• Published in: The Journal of biological chemistry Vol. 286; no. 39; pp. 34298 - 34310
• Main Authors: Hattori, Noriko, Carrino, David A., Lauer, Mark E., Vasanji, Amit, Wylie, James D., Nelson, Courtney M., Apte, Suneel S.
• Format: Journal Article
• Language: English
• Published: Elsevier Inc 01.09.2011
• Subjects: ADAM ADAMTS; Extracellular Matrix; Fibroblast; Fibrosis; Mouse Genetics; Myofibroblast; Pericellular Matrix; Proteoglycan Synthesis; Versican; ADAM ADAMTS; Pericellular Matrix; Extracellular Matrix; Proteoglycan Synthesis; Myofibroblast; Fibrosis; Mouse Genetics; Fibroblast; Versican

The cell and its glycosaminoglycan-rich pericellular matrix (PCM) comprise a functional unit. Because modification of PCM influences cell behavior, we investigated molecular mechanisms that regulate PCM volume and composition. In fibroblasts and other cells, aggregates of hyaluronan and versican are...