Signal Transduction of Pregnenolone Sulfate in Insulinoma Cells

• Published in: The Journal of biological chemistry Vol. 286; no. 12; pp. 10084 - 10096
• Main Authors: Mayer, Sabine I., Müller, Isabelle, Mannebach, Stefanie, Endo, Takeshi, Thiel, Gerald
• Format: Journal Article
• Language: English
• Published: Elsevier Inc 01.03.2011
• Subjects: Chromogranin B; Egr-1; ERK; Insulin; Lentivirus; Pancreatic Islet; Pdx-1; Steroid; Synapsin I; Ternary Complex Factor; Pancreatic Islet; Steroid; Synapsin I; Chromogranin B; Ternary Complex Factor; Egr-1; Insulin; Lentivirus; Pdx-1; ERK

The neurosteroid pregnenolone sulfate acts on the nervous system by modifying neurotransmission and receptor functions, thus influencing synaptic strength, neuronal survival, and neurogenesis. Here we show that pregnenolone sulfate induces a signaling cascade in insulinoma cells leading to enhanced...