Endorepellin Affects Angiogenesis by Antagonizing Diverse Vascular Endothelial Growth Factor Receptor 2 (VEGFR2)-evoked Signaling Pathways

• Published in: The Journal of biological chemistry Vol. 287; no. 52; pp. 43543 - 43556
• Main Authors: Goyal, Atul, Poluzzi, Chiara, Willis, Chris D., Smythies, James, Shellard, Adam, Neill, Thomas, Iozzo, Renato V.
• Format: Journal Article
• Language: English
• Published: Elsevier Inc 01.12.2012
• Subjects: Angiogenesis; AP1; Calcineurin; Endothelial Cell; NFAT1; Perlecan; Proteoglycan; Vascular Biology; Vascular Endothelial Growth Factor (VEGF); VEGF Receptor 2; Proteoglycan; Angiogenesis; Vascular Endothelial Growth Factor (VEGF); AP1; VEGF Receptor 2; Vascular Biology; Calcineurin; Perlecan; Endothelial Cell; NFAT1

Endorepellin, the angiostatic C-terminal domain of the heparan sulfate proteoglycan perlecan, inhibits angiogenesis by simultaneously binding to the α2β1 integrin and the vascular endothelial growth factor (VEGF) receptor 2 (VEGFR2) on endothelial cells. This interaction triggers the down-regulation...