A Genome‐Wide Survey of DNA Methylation Status in Whole Blood of Patients With Hidradenitis Suppurativa Suggests Systemic Immune Dysregulation and Systemic Disease Burden

• Published in: Experimental dermatology Vol. 34; no. 2; pp. e70065 - n/a
• Main Authors: Montoya, Marco, Khetani, Radhika, Martinez, Rebeca, Mayur, Omkar, Yi, Julie Z., McGee, Jean S.
• Format: Journal Article
• Language: English
• Published: Denmark Wiley Subscription Services, Inc 01.02.2025
• Subjects: Adaptive immunity; Adult; and whole blood; Case-Control Studies; DNA Methylation; DNA probes; Epigenesis, Genetic; Epigenetics; Female; Genome-Wide Association Study; Genomes; hidradenitis suppurativa; Hidradenitis Suppurativa - blood; Hidradenitis Suppurativa - genetics; Hidradenitis Suppurativa - immunology; Humans; Immune response; Immunity, Innate - genetics; Interferon-gamma - metabolism; Male; Malignancy; Middle Aged; Signal transduction; Skin diseases; systemic disease burden; Systemic diseases; systemic malignancy risk; Tumor suppressor genes; systemic disease burden; DNA methylation; systemic malignancy risk; hidradenitis suppurativa; and whole blood; epigenetics

ABSTRACT Hidradenitis suppurativa (HS) is a chronic inflammatory skin disease with a significant systemic disease burden. In this study, we profiled and compared the DNA methylation patterns in whole blood of HS patients versus control subjects to identify associated genes and biological pathways en...