A pragmatic, single-arm clinical trial of a dose modification algorithm for preventing cytopenia-related delays during FOLFOX chemotherapy

• Published in: Supportive care in cancer Vol. 33; no. 9; p. 769
• Main Authors: Wright, Heather N., Tosteson, Tor D., Hourdequin, Kathryn C., Ripple, Gregory H., Fuld, Alexander D., Dragnev, Konstantin H., Amin, Manik, Muralikrishnan, Sivraj, McGrath, Elizabeth B., Stannard, Maureen G., Schofield, Lora L., Lord-Halvorson, Sierra, Tosteson, Anna N. A., Brooks, Gabriel A.
• Format: Journal Article
• Language: English
• Published: Berlin/Heidelberg Springer Berlin Heidelberg 01.09.2025; Springer Nature B.V
• Subjects: Adult; Aged; Algorithms; Antineoplastic Combined Chemotherapy Protocols - administration & dosage; Antineoplastic Combined Chemotherapy Protocols - adverse effects; Antineoplastic Combined Chemotherapy Protocols - therapeutic use; Blood platelets; Blood tests; Cancer therapies; Chemotherapy; Clinical medicine; Clinical trials; Cytopenia - blood; Cytopenia - chemically induced; Cytopenia - prevention & control; Dose-Response Relationship, Drug; Female; Fluorouracil - administration & dosage; Fluorouracil - adverse effects; Humans; Internet resources; Leucovorin - administration & dosage; Leucovorin - adverse effects; Male; Medicine; Medicine & Public Health; Middle Aged; Monoclonal antibodies; Neoplasms - blood; Neoplasms - drug therapy; Neutropenia; Neutrophils; Nursing; Nursing Research; Oncology; Organoplatinum Compounds - administration & dosage; Organoplatinum Compounds - adverse effects; Oxaliplatin - administration & dosage; Oxaliplatin - adverse effects; Pain Medicine; Patients; Platelet Count; Rehabilitation Medicine; Schedules; Thrombocytopenia; FOLFOX chemotherapy; Unplanned delay; Relative dose intensity

Purpose Unplanned delays are common during FOLFOX chemotherapy. We evaluated a novel FOLFOX dose modification algorithm designed to reduce unplanned delays while maintaining dose intensity. Methods We conducted a pragmatic, single-arm clinical trial to evaluate PAGODA, a proactive graduated dose mod...