A pragmatic, single-arm clinical trial of a dose modification algorithm for preventing cytopenia-related delays during FOLFOX chemotherapy - Wright, Heather N.; Tosteson, Tor D.; Hourdequin, Kathryn C.; Ripple, Gregory H.; Fuld, Alexander D.; Dragnev, Konstantin H.; Amin, Manik; Muralikrishnan, Sivraj; McGrath, Elizabeth B.; Stannard, Maureen G.; Schofield, Lora L.; Lord-Halvorson, Sierra; et al. (Supportive care in cancer, 2025)
Keywords: Adult; Aged; Algorithms; Antineoplastic Combined Chemotherapy Protocols - administration & dosage; Antineoplastic Combined Chemotherapy Protocols - adverse effects; Antineoplastic Combined Chemotherapy Protocols - therapeutic use; Blood platelets; Blood tests; Cancer therapies; Chemotherapy; Clinical medicine; Clinical trials; Cytopenia - blood; Cytopenia - chemically induced; Cytopenia - prevention & control; Dose-Response Relationship, Drug; Female; Fluorouracil - administration & dosage; Fluorouracil - adverse effects; Humans; Internet resources; Leucovorin - administration & dosage; Leucovorin - adverse effects; Male; Medicine; Medicine & Public Health; Middle Aged; Monoclonal antibodies; Neoplasms - blood; Neoplasms - drug therapy; Neutropenia; Neutrophils; Nursing; Nursing Research; Oncology; Organoplatinum Compounds - administration & dosage; Organoplatinum Compounds - adverse effects; Oxaliplatin - administration & dosage; Oxaliplatin - adverse effects; Pain Medicine; Patients; Platelet Count; Rehabilitation Medicine; Schedules; Thrombocytopenia; FOLFOX chemotherapy; Unplanned delay; Relative dose intensity