Potentiation of insulin-like growth factor-I (IGF-I) activity by an antibody: supportive evidence for enhancement of IGF-I bioavailability in vivo by IGF binding proteins

• Published in: Endocrinology (Philadelphia) Vol. 133; no. 3; p. 1462
• Main Authors: Stewart, C E, Bates, P C, Calder, T A, Woodall, S M, Pell, J M
• Format: Journal Article
• Language: English
• Published: United States 01.09.1993
• Subjects: Animals; Antibodies - metabolism; Carrier Proteins - physiology; Dwarfism - physiopathology; Female; Immune Sera - immunology; Immunization, Passive; Insulin-Like Growth Factor Binding Proteins; Insulin-Like Growth Factor I - immunology; Insulin-Like Growth Factor I - pharmacology; Insulin-Like Growth Factor I - physiology; Male; Mice; Mice, Mutant Strains; Rats; Rats, Mutant Strains; Recombinant Proteins - immunology; Sheep - immunology; Weight Gain

The effects of ovine polyclonal antibodies raised against human recombinant IGF-I were investigated in GH-deficient rodents in vivo both in the presence and absence of exogenous IGF-I. Dwarf mice (negligible endogenous serum IGF-I) treated with anti-IGF-I serum which had been pre-incubated with IGF-...