Case report on two-cathinones abuse: MPHP and N-ethyl-4′methylnorpentedrone, with a fatal outcome
Purpose The correlation between the rising consumption of new psychoactive drugs (NPS), including that of cathinones, and the occurrence of death has not been sufficiently backed up with published analytic data. In fact, the identification of cathinones in human biological samples remains difficult...
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Published in | Forensic toxicology Vol. 38; no. 1; pp. 243 - 254 |
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Main Authors | , , , , , , , , , , , |
Format | Journal Article |
Language | English |
Published |
Singapore
Springer Singapore
2020
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Subjects | |
Online Access | Get full text |
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Abstract | Purpose
The correlation between the rising consumption of new psychoactive drugs (NPS), including that of cathinones, and the occurrence of death has not been sufficiently backed up with published analytic data. In fact, the identification of cathinones in human biological samples remains difficult mainly due to the diversity of these substances and their high turnover. In this context, this manuscript aims at documenting a fatal case of a 39-year-old man: autopsy findings consisted in unspecific asphyxic syndrome.
Methods
Blood ethanol concentration determination and toxicological screenings were performed using gas chromatography with flame ionization detection, liquid chromatography with diode array detection and gas chromatography with mass spectrometry detection, respectively. Liquid chromatography with high-resolution mass spectrometry detection allowed the confirmation of the presence of NPS and the subsequent metabolic study.
Results
The analyses have shown the presence of ethanol, tetrahydrocannabinol and two cathinones, 4′-methyl-α-pyrrolidinohexanophenone (MPHP) and
N
-ethyl-4′-methylnorpentedrone (4-MEAP). MPHP/4-MEAP concentrations were 47/1.6, 97/3.5 and 2380/49,700 µg/L in femoral blood, cardiac blood and urine, respectively. The in vitro metabolic study has highlighted the presence of five metabolites derived from MPHP and three from 4-MEAP but only two metabolites of these products have been detected in biological samples. The 4′-carboxy-PHP, one of the metabolites of MPHP, was detected in every biological sample with higher chromatographic signals than MPHP itself.
Conclusions
The number of fatalities related to cathinones use is expected to increase in the coming years. This manuscript reports useful analytical data about MPHP, one of its metabolites (4′-carboxy-PHP) and 4-MEAP. |
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AbstractList | Purpose
The correlation between the rising consumption of new psychoactive drugs (NPS), including that of cathinones, and the occurrence of death has not been sufficiently backed up with published analytic data. In fact, the identification of cathinones in human biological samples remains difficult mainly due to the diversity of these substances and their high turnover. In this context, this manuscript aims at documenting a fatal case of a 39-year-old man: autopsy findings consisted in unspecific asphyxic syndrome.
Methods
Blood ethanol concentration determination and toxicological screenings were performed using gas chromatography with flame ionization detection, liquid chromatography with diode array detection and gas chromatography with mass spectrometry detection, respectively. Liquid chromatography with high-resolution mass spectrometry detection allowed the confirmation of the presence of NPS and the subsequent metabolic study.
Results
The analyses have shown the presence of ethanol, tetrahydrocannabinol and two cathinones, 4′-methyl-α-pyrrolidinohexanophenone (MPHP) and
N
-ethyl-4′-methylnorpentedrone (4-MEAP). MPHP/4-MEAP concentrations were 47/1.6, 97/3.5 and 2380/49,700 µg/L in femoral blood, cardiac blood and urine, respectively. The in vitro metabolic study has highlighted the presence of five metabolites derived from MPHP and three from 4-MEAP but only two metabolites of these products have been detected in biological samples. The 4′-carboxy-PHP, one of the metabolites of MPHP, was detected in every biological sample with higher chromatographic signals than MPHP itself.
Conclusions
The number of fatalities related to cathinones use is expected to increase in the coming years. This manuscript reports useful analytical data about MPHP, one of its metabolites (4′-carboxy-PHP) and 4-MEAP. |
Author | Camille, Richeval Marie, Deguigne Morgan, Brofferio Benedicte, Lelievre Severine, Ferec Deborah, Iwanikow Delphine, Allorge David, Boels Nathalie, Jousset Jean-Michel, Gaulier Guillaume, Drevin Audrey, Coulon |
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Cites_doi | 10.1016/j.lfs.2013.07.023 10.1002/dta.2099 10.1021/jm050797a 10.1016/j.euroneuro.2011.07.009 10.1007/s11419-017-0385-6 10.1016/j.forsciint.2006.05.021 10.1007/s11419-016-0307-z 10.1111/j.1360-0443.2011.03502.x 10.1016/j.forsciint.2011.02.026 10.1016/S1570-0232(03)00043-6 10.1007/s13181-011-0199-6 10.1002/dta.2326 10.1080/15563650.2016.1271132 10.1007/s00216-013-7574-x 10.1007/s11419-017-0393-6 10.1002/dta.2480 10.1002/dta.313 10.1016/j.aca.2004.08.055 10.1016/j.forsciint.2006.07.024 10.1007/s00414-015-1212-4 10.1007/s00769-011-0775-0 10.1002/dta.1865 10.1111/1556-4029.12712 10.1002/wps.20174 10.1007/s00204-013-1163-9 10.1038/npp.2011.304 10.1093/jat/bkx031 10.1002/hup.2423 10.1016/0006-2952(78)90180-6 10.2174/1389201018666171122124401 10.1093/clinchem/37.7.1210 |
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Keywords | Cathinones Fatal Ethyl-4′-methylnorpentedrone (4-MEAP) 4′-Methyl-α-pyrrolidinohexanophenone (MPHP) 4′-Carboxy-PHP |
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The correlation between the rising consumption of new psychoactive drugs (NPS), including that of cathinones, and the occurrence of death has not been... |
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Title | Case report on two-cathinones abuse: MPHP and N-ethyl-4′methylnorpentedrone, with a fatal outcome |
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