Release characteristics of cannabidiol isolate based on polysaccharide edible film: comparative study

• Published in: Emergent materials (Online) Vol. 6; no. 3; pp. 917 - 926
• Main Authors: Sukhavattanakul, Pongpat, Thanyacharoen, Thanyaluck, Chuysinuan, Piyachat, Techasakul, Supanna, Ummartyotin, Sarute
• Format: Journal Article
• Language: English
• Published: Cham Springer International Publishing 01.06.2023
• Subjects: Chemistry and Materials Science; Energy Materials; Materials Engineering; Materials Science; Original Article; Antioxidant activities; Edible film; Release characteristic; Cannabidiol isolate
• ISSN: 2522-5731; 2522-574X
• DOI: 10.1007/s42247-023-00487-y

Various types of polysaccharide-based edible films were successfully prepared by the casting technique. Sodium alginate (Alg), gelatin (Gel), sodium alginate/hydrolyzed collagen (AlgCG), and carboxymethyl cellulose (CMC) were used as polysaccharide bases. The presence of cannabidiol isolate (CBDi) was loaded due to antioxidant activity enhancement. It was adhered to the hydroxyl group throughout the polysaccharide structure. When CBDi particles were incorporated, no observable change in structural characteristics and an irregular manner of swelling behavior were shown. The morphology was displayed as a thin layer of film that had CBDi particles that were evenly dispersed throughout the film. After a quick early onset, the swelling behavior in the food simulant solution stabilized after 4 h. The role of CBDi particles significantly provided antioxidant activity, as reported by the DPPH assay, ABTS assay, and FRAP assay. Gel-based edible polysaccharide films exhibited the highest antioxidant activity. Therefore, as prepared, CBDi loaded into AlgCG, CMC, Alg, and Gel-based edible polysaccharide films has the potential for edible film applications such as active film for food packaging. Graphical Abstract