Antimicrobial Resistance in Urinary Tract Infections

• Published in: Current bladder dysfunction reports Vol. 18; no. 1; pp. 1 - 9
• Main Authors: Damm, Tiffany L., Cameron, Anne P.
• Format: Journal Article
• Language: English
• Published: New York Springer US 01.03.2023
• Subjects: Geriatrics/Gerontology; Gynecology; Inflammatory/Infectious Bladder Disorders (MS Mourad; Medicine; Medicine & Public Health; Section Editor; Topical Collection on Inflammatory/Infectious Bladder Disorders; Urology; Urinary tract infection; Multidrug-resistant urinary tract infection; Antimicrobial resistance; Antibiotic stewardship
• ISSN: 1931-7212; 1931-7220
• DOI: 10.1007/s11884-022-00674-3

Purpose of Review This review aims to summarize the recent literature regarding antimicrobial-resistant urinary tract infections in the United States and discuss the impact on the care of urologic patients. We discuss strategies to mitigate the development of antimicrobial resistance and outline basic recommendations for empiric treatment of antimicrobial-resistant urinary tract infections. Recent Findings Several studies have attempted to evaluate the prevalence, risk factors, burden, and implications of antimicrobial-resistant urinary tract infections. Recent guidelines from the Infectious Disease Society of America in 2011 and 2022 provide recommendations for empiric acute uncomplicated cystitis treatment and considerations for empiric treatment of antimicrobial-resistant infections, respectively. Summary Antimicrobial-resistant urinary tract infections are common in urologic patients and increase the risk of adverse effects when not appropriately treated. It is a urologists’ due diligence to prescribe appropriate antimicrobial prophylaxis and treatment and to prevent further development of antimicrobial resistance. Novel non-antimicrobial therapies are promising for treatment and reduction of antimicrobial-resistant infections but require further investigation.