Synthesis, characterization, crystallographic, binding, in silico and antidiabetic studies of novel 2,4-thiazolidinedione-phenothiazine molecular hybrids

• Published in: Journal of molecular structure Vol. 1276; p. 134625
• Main Authors: Doddagaddavalli, Manasa A., Kalalbandi, Veerendra Kumar A., Seetharamappa, Jaldappagari
• Format: Journal Article
• Language: English
• Published: Elsevier B.V 15.03.2023
• Subjects: 2,4-thiazolidinediones- Phenothiazine scaffolds; Antidiabetic activity; Binding studies; Crystallographic studies; In silico studies; In silico studies; Crystallographic studies; Antidiabetic activity; 2,4-thiazolidinediones- Phenothiazine scaffolds; Binding studies

•The synthesized compounds displayed potent in vitro antidiabetic activity.•The single-crystal X-ray investigation validated the molecular structure.•The interaction of compounds with HSA has been studied.•Molecular docking studies were carried out. 2,4-thiazolidinedione-phenothiazine molecular hybr...