The Peptidome Comes of Age: Mass Spectrometry-Based Characterization of the Circulating Cancer Peptidome

• Published in: The Enzymes Vol. 42; p. 27
• Main Authors: Greening, David W, Kapp, Eugene A, Simpson, Richard J
• Format: Journal Article
• Language: English
• Published: United States 2017
• Subjects: Peptides; Proteolysis; Proteomics; Biomarkers; Top-down proteomics; Informatics; Mass spectrometry; Cancer; Peptidome

Peptides play a seminal role in most physiological processes acting as neurotransmitters, hormones, antibiotics, and immune regulation. In the context of tumor biology, it is hypothesized that endogenous peptides, hormones, cytokines, growth factors, and aberrant degradation of select protein networ...