SENP2-NDR2-p21 axis modulates lung cancer cell growth

• Published in: European journal of pharmacology Vol. 978; p. 176761
• Main Authors: Cheng, Yixuan, Hou, Wanxin, Fang, Houshun, Yan, Yinjie, Lu, Yiming, Meng, Tian, Ma, Chunshuang, Liu, Qinghai, Zhou, Zhiyi, Li, Hui, Li, Hegen, Xiao, Ning
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier B.V 05.09.2024
• Subjects: Astragaloside IV; Cell cycle; Lung cancer; NDR2/STK38L; SENP2; SENP; NDR2; AS-IV; FDA; SUMO; NDR2/STK38L; Lung cancer; JOL; Cell cycle; STK38L; SENP2; Astragaloside IV

Sentrin/small ubiquitin-like modifier (SUMO)-specific proteases (SENPs) perform pivotal roles in SUMO maturation and recycling, which modulate the balance of SUMOylation/de-SUMOylation and spatiotemporal functions of SUMOylation targets. The malfunction of SENPs often results in cellular dysfunction...