Application of a bespoke monoclonal antibody panel to characterize immune cell populations in cave nectar bats

Among their many unique biological features, bats are increasingly recognized as a key reservoir of many emerging viruses that cause massive morbidity and mortality in humans. Bats are capable of harboring many of these deadly viruses without any apparent signs of pathology, in a mechanism known as...

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Published inCell reports (Cambridge) Vol. 43; no. 9; p. 114703
Main Authors Chen, Shiwei, Sia, Wan Rong, Tang, Leon J.W., Gamage, Akshamal M., Chan, Wharton O.Y., Zhu, Feng, Chia, Wanni, Kwek, Madeline S.S., Kong, Pui San, Lim, Beng Lee, Foo, Randy, Ng, Wei Lun, Tan, Adrian H.J., He, Shan, Loh, Abigail Y.T., Low, Dolyce H.W., Smith, Gavin J.D., Hong, Lewis Z., Wang, Lin-Fa
Format Journal Article
LanguageEnglish
Published United States Elsevier Inc 24.09.2024
Subjects
bat
disease tolerance
immunology
mAb
monoclonal antibody
CP: Immunology
bat
monoclonal antibody
immunology
disease tolerance
mAb
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Abstract Among their many unique biological features, bats are increasingly recognized as a key reservoir of many emerging viruses that cause massive morbidity and mortality in humans. Bats are capable of harboring many of these deadly viruses without any apparent signs of pathology, in a mechanism known as viral disease tolerance. However, the immunological mechanisms behind viral tolerance remain poorly understood. As a non-model organism species, there are very limited research resources and tools available to study bat immunology. In the cave nectar bat Eonycteris spelaea, we have a panel of monoclonal antibodies (mAbs) against major immune markers. An immunophenotyping survey of major immune compartments and barrier sites using these mAbs reveals differences in the immunological landscape of bats. [Display omitted] •Development of a panel of monoclonal antibodies specific to E. spelaea•Flow cytometric phenotyping of multiple tissues to compare bats and mice•Bats have fewer B cells and a skewing of monocytes toward the non-classical lineage•CD4 and CD21 mAbs demonstrate cross-reactivity to two other bat species Bats are reservoir hosts of many viruses, harboring these viruses using unique mechanisms of viral tolerance. However, immunological study has been impaired by a lack of suitable tools. Chen et al. address this limitation by the usage of a panel of bat-specific monoclonal antibodies for flow cytometry.
AbstractList Among their many unique biological features, bats are increasingly recognized as a key reservoir of many emerging viruses that cause massive morbidity and mortality in humans. Bats are capable of harboring many of these deadly viruses without any apparent signs of pathology, in a mechanism known as viral disease tolerance. However, the immunological mechanisms behind viral tolerance remain poorly understood. As a non-model organism species, there are very limited research resources and tools available to study bat immunology. In the cave nectar bat Eonycteris spelaea, we have a panel of monoclonal antibodies (mAbs) against major immune markers. An immunophenotyping survey of major immune compartments and barrier sites using these mAbs reveals differences in the immunological landscape of bats. [Display omitted] •Development of a panel of monoclonal antibodies specific to E. spelaea•Flow cytometric phenotyping of multiple tissues to compare bats and mice•Bats have fewer B cells and a skewing of monocytes toward the non-classical lineage•CD4 and CD21 mAbs demonstrate cross-reactivity to two other bat species Bats are reservoir hosts of many viruses, harboring these viruses using unique mechanisms of viral tolerance. However, immunological study has been impaired by a lack of suitable tools. Chen et al. address this limitation by the usage of a panel of bat-specific monoclonal antibodies for flow cytometry.
Among their many unique biological features, bats are increasingly recognized as a key reservoir of many emerging viruses that cause massive morbidity and mortality in humans. Bats are capable of harboring many of these deadly viruses without any apparent signs of pathology, in a mechanism known as viral disease tolerance. However, the immunological mechanisms behind viral tolerance remain poorly understood. As a non-model organism species, there are very limited research resources and tools available to study bat immunology. In the cave nectar bat Eonycteris spelaea, we have a panel of monoclonal antibodies (mAbs) against major immune markers. An immunophenotyping survey of major immune compartments and barrier sites using these mAbs reveals differences in the immunological landscape of bats.
Among their many unique biological features, bats are increasingly recognized as a key reservoir of many emerging viruses that cause massive morbidity and mortality in humans. Bats are capable of harboring many of these deadly viruses without any apparent signs of pathology, in a mechanism known as viral disease tolerance. However, the immunological mechanisms behind viral tolerance remain poorly understood. As a non-model organism species, there are very limited research resources and tools available to study bat immunology. In the cave nectar bat Eonycteris spelaea, we have a panel of monoclonal antibodies (mAbs) against major immune markers. An immunophenotyping survey of major immune compartments and barrier sites using these mAbs reveals differences in the immunological landscape of bats.Among their many unique biological features, bats are increasingly recognized as a key reservoir of many emerging viruses that cause massive morbidity and mortality in humans. Bats are capable of harboring many of these deadly viruses without any apparent signs of pathology, in a mechanism known as viral disease tolerance. However, the immunological mechanisms behind viral tolerance remain poorly understood. As a non-model organism species, there are very limited research resources and tools available to study bat immunology. In the cave nectar bat Eonycteris spelaea, we have a panel of monoclonal antibodies (mAbs) against major immune markers. An immunophenotyping survey of major immune compartments and barrier sites using these mAbs reveals differences in the immunological landscape of bats.
ArticleNumber 114703
Author Ng, Wei Lun
Smith, Gavin J.D.
Chan, Wharton O.Y.
Kong, Pui San
Tang, Leon J.W.
Gamage, Akshamal M.
Zhu, Feng
Wang, Lin-Fa
Lim, Beng Lee
Hong, Lewis Z.
Loh, Abigail Y.T.
Low, Dolyce H.W.
Chia, Wanni
Foo, Randy
Chen, Shiwei
He, Shan
Tan, Adrian H.J.
Kwek, Madeline S.S.
Sia, Wan Rong
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  givenname: Shan
  surname: He
  fullname: He, Shan
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  surname: Loh
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  organization: Paratus Sciences, Singapore, Singapore
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  surname: Wang
  fullname: Wang, Lin-Fa
  email: linfa.wang@duke-nus.edu.sg
  organization: Programme in Emerging Infectious Diseases, Duke-NUS Medical School, Singapore, Singapore
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Keywords CP: Immunology
bat
monoclonal antibody
immunology
disease tolerance
mAb
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Snippet Among their many unique biological features, bats are increasingly recognized as a key reservoir of many emerging viruses that cause massive morbidity and...
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SubjectTerms bat
disease tolerance
immunology
mAb
monoclonal antibody
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Title Application of a bespoke monoclonal antibody panel to characterize immune cell populations in cave nectar bats
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