The hidden elephant: Modified abasic sites and their consequences

• Published in: DNA repair Vol. 148; p. 103823
• Main Authors: Yudkina, Anna V., Zharkov, Dmitry O.
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier B.V 01.04.2025
• Subjects: Animals; AP sites; DNA - chemistry; DNA - metabolism; DNA adducts; DNA Adducts - chemistry; DNA Adducts - metabolism; DNA Damage; DNA Repair; DNA–peptide cross-links; DNA–protein cross-links; Humans; Interstrand cross-links; Oxidation-Reduction; Interstrand cross-links; AP sites; DNA adducts; DNA–peptide cross-links; DNA–protein cross-links

Abasic, or apurinic/apyrimidinic sites (AP sites) are among the most abundant DNA lesions, appearing in DNA both through spontaneous base loss and as intermediates of base excision DNA repair. Natural aldehydic AP sites have been known for decades and their interaction with the cellular replication,...