Perioperative outcomes after hepatectomy for hepatocellular carcinoma among patients with cirrhosis, fatty liver disease, and clinically normal livers

• Published in: Surgical oncology Vol. 56; p. 102114
• Main Authors: Gupta, Meera, Davenport, Daniel, Orozco, Gabriel, Bharadwaj, Rashmi, Roses, Robert E., Evers, B Mark, Zwischenberger, Joseph, Ancheta, Alexandre, Shah, Malay B., Gedaly, Roberto
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier Ltd 01.10.2024
• Subjects: Carcinoma; Hepatectomy; Hepatocellular; Liver cirrhosis; Hepatocellular; Carcinoma; Liver cirrhosis; Hepatectomy
• DOI: 10.1016/j.suronc.2024.102114
• ISSN: 0960-7404; 1879-3320

Despite superior outcomes with liver transplantation, cirrhotic patients with HCC may turn to other forms of definitive treatment. To understand perioperative outcomes, we examined perioperative mortality and major morbidity after hepatectomy for HCC among cirrhotic and non-cirrhotic patients. ology: The American College of Surgeons National Surgical Quality Improvement Project (ACS-NSQIP) database was queried for liver resection for HCC. Multivariable logistic regression was performed to determine the association between liver texture and risk of major non-infectious morbidity, post-hepatectomy liver failure (PHLF) and 30-day mortality. From 2014 to 2018, 2203 patients underwent hepatectomy: 58.6 % cirrhotic, 12.8 % fatty and 28.6 % normal texture. Overall 30 day-mortality was 2.1 % (n = 46), although higher among fatty liver (2.8 %) and cirrhotic (2.6 %; p = 0.025) patients. The incidence of PHLF was 6.9 %, with hepatectomy type, cirrhosis, and platelet count as major risk factors. Age, resection type, and platelet count were associated with major complications. Trisegmentectomy and right hepatectomy (OR = 3.60, OR = 3.46, respectively) conferred a greater risk of major noninfectious morbidity compared to partial hepatectomy. Among cirrhotics alone, hepatectomy type, platelet count, preoperative sepsis and ASA class were associated with major morbidity. Hepatic parenchymal disease/texture and function, presence of portal hypertension, and the extent of the liver resection are critical determinants of perioperative risk among HCC patients. •This ACS-NSQIP study examines outcomes after hepatectomy for HCC among cirrhotic, fatty liver, and normal liver patients.•Overall 30 day-mortality is higher among fatty liver and cirrhotic patients.•Liver resection confers an increasedrisk for mortality, post-hepatectomy liver failure, and morbidity among cirrhotics.•Hepatic echotexture & function, portal hypertension, and resection are determinants of perioperative risk among HCC patients.