Polyamines in human brain tumors. A correlative study between tumor, cerebrospinal fluid and red blood cell free polyamine levels

Polyamine levels have been studied in brain tumor patients. We focused our study on the relationship between tumor, cerebrospinal fluid (CSF) and red blood cell (RBC) polyamine levels. Our results are the following: Polyamine levels in CSF are consistently increased, whatever the histological type m...

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Bibliographic Details
Published inJournal of neuro-oncology Vol. 2; no. 2; p. 153
Main Authors Moulinoux, J P, Quemener, V, Le Calve, M, Chatel, M, Darcel, F
Format Journal Article
LanguageEnglish
Published United States 01.01.1984
Subjects
Astrocytoma - analysis
Brain Neoplasms - analysis
Brain Neoplasms - blood
Brain Neoplasms - cerebrospinal fluid
Erythrocytes - analysis
Glioma - analysis
Humans
Medulloblastoma - analysis
Meningioma - analysis
Polyamines - analysis
Polyamines - blood
Polyamines - cerebrospinal fluid
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Summary:Polyamine levels have been studied in brain tumor patients. We focused our study on the relationship between tumor, cerebrospinal fluid (CSF) and red blood cell (RBC) polyamine levels. Our results are the following: Polyamine levels in CSF are consistently increased, whatever the histological type may be. The highest tumoral concentrations are found in medulloblastoma. In glioblastomas, the RBC spermidine levels are higher than in the other types of tumors and there is a highly significant correlation between the spermidine/spermine ratio in tumor and RBC. Therefore, RBC polyamine determination might be of clinical interest in the monitoring of patients with glioblastomas.
ISSN:0167-594X
1573-7373
DOI:10.1007/BF00177902