Exploring antimalarial potential: Conjugating organometallic moieties with organic fragments for enhanced efficacy
[Display omitted] In the search for novel ligands with efficacy against various diseases, particularly parasitic diseases, molecular hybridization of organometallic units into biologically active scaffolds has been hailed as an appealing strategy in medicinal chemistry. The conjugation to organometa...
Saved in:
Published in | Bioorganic chemistry Vol. 149; p. 107510 |
---|---|
Main Authors | , , , , , , , , , , |
Format | Journal Article |
Language | English |
Published |
United States
Elsevier Inc
01.08.2024
|
Subjects | |
Online Access | Get full text |
Cover
Loading…
Abstract | [Display omitted]
In the search for novel ligands with efficacy against various diseases, particularly parasitic diseases, molecular hybridization of organometallic units into biologically active scaffolds has been hailed as an appealing strategy in medicinal chemistry. The conjugation to organometallic fragments can be achieved by an appropriate linker or by directly coordinating the existing drugs to a metal. The success of Ferroquine (FQ, SR97193), an effective chloroquine–ferrocene conjugate currently undergoing the patient-exploratory phase as a combination therapy with the novel triaminopyrimidine ZY-19489 for malaria, has sparked intense interest in organometallic compound drug discovery. We present the evolution of organometallic antimalarial agents over the last decade, focusing on the parent moiety’s class and the type of organometallics involved. Four main organometallic antimalarial compounds have been chosen based on conjugated organic moieties: existing antimalarial drugs, other clinical drugs, hybrid drugs, and promising scaffolds of thiosemicarbazones, benzimidazoles, and chalcones, in particular. The presented insights contribute to the ongoing discourse on organometallic compound drug development for malaria diseases. |
---|---|
AbstractList | In the search for novel ligands with efficacy against various diseases, particularly parasitic diseases, molecular hybridization of organometallic units into biologically active scaffolds has been hailed as an appealing strategy in medicinal chemistry. The conjugation to organometallic fragments can be achieved by an appropriate linker or by directly coordinating the existing drugs to a metal. The success of Ferroquine (FQ, SR97193), an effective chloroquine-ferrocene conjugate currently undergoing the patient-exploratory phase as a combination therapy with the novel triaminopyrimidine ZY-19489 for malaria, has sparked intense interest in organometallic compound drug discovery. We present the evolution of organometallic antimalarial agents over the last decade, focusing on the parent moiety's class and the type of organometallics involved. Four main organometallic antimalarial compounds have been chosen based on conjugated organic moieties: existing antimalarial drugs, other clinical drugs, hybrid drugs, and promising scaffolds of thiosemicarbazones, benzimidazoles, and chalcones, in particular. The presented insights contribute to the ongoing discourse on organometallic compound drug development for malaria diseases.In the search for novel ligands with efficacy against various diseases, particularly parasitic diseases, molecular hybridization of organometallic units into biologically active scaffolds has been hailed as an appealing strategy in medicinal chemistry. The conjugation to organometallic fragments can be achieved by an appropriate linker or by directly coordinating the existing drugs to a metal. The success of Ferroquine (FQ, SR97193), an effective chloroquine-ferrocene conjugate currently undergoing the patient-exploratory phase as a combination therapy with the novel triaminopyrimidine ZY-19489 for malaria, has sparked intense interest in organometallic compound drug discovery. We present the evolution of organometallic antimalarial agents over the last decade, focusing on the parent moiety's class and the type of organometallics involved. Four main organometallic antimalarial compounds have been chosen based on conjugated organic moieties: existing antimalarial drugs, other clinical drugs, hybrid drugs, and promising scaffolds of thiosemicarbazones, benzimidazoles, and chalcones, in particular. The presented insights contribute to the ongoing discourse on organometallic compound drug development for malaria diseases. In the search for novel ligands with efficacy against various diseases, particularly parasitic diseases, molecular hybridization of organometallic units into biologically active scaffolds has been hailed as an appealing strategy in medicinal chemistry. The conjugation to organometallic fragments can be achieved by an appropriate linker or by directly coordinating the existing drugs to a metal. The success of Ferroquine (FQ, SR97193), an effective chloroquine-ferrocene conjugate currently undergoing the patient-exploratory phase as a combination therapy with the novel triaminopyrimidine ZY-19489 for malaria, has sparked intense interest in organometallic compound drug discovery. We present the evolution of organometallic antimalarial agents over the last decade, focusing on the parent moiety's class and the type of organometallics involved. Four main organometallic antimalarial compounds have been chosen based on conjugated organic moieties: existing antimalarial drugs, other clinical drugs, hybrid drugs, and promising scaffolds of thiosemicarbazones, benzimidazoles, and chalcones, in particular. The presented insights contribute to the ongoing discourse on organometallic compound drug development for malaria diseases. [Display omitted] In the search for novel ligands with efficacy against various diseases, particularly parasitic diseases, molecular hybridization of organometallic units into biologically active scaffolds has been hailed as an appealing strategy in medicinal chemistry. The conjugation to organometallic fragments can be achieved by an appropriate linker or by directly coordinating the existing drugs to a metal. The success of Ferroquine (FQ, SR97193), an effective chloroquine–ferrocene conjugate currently undergoing the patient-exploratory phase as a combination therapy with the novel triaminopyrimidine ZY-19489 for malaria, has sparked intense interest in organometallic compound drug discovery. We present the evolution of organometallic antimalarial agents over the last decade, focusing on the parent moiety’s class and the type of organometallics involved. Four main organometallic antimalarial compounds have been chosen based on conjugated organic moieties: existing antimalarial drugs, other clinical drugs, hybrid drugs, and promising scaffolds of thiosemicarbazones, benzimidazoles, and chalcones, in particular. The presented insights contribute to the ongoing discourse on organometallic compound drug development for malaria diseases. |
ArticleNumber | 107510 |
Author | Huda Abd Karim, Nurul Hamizah Ali, Amatul Kartini Agustar, Hani Izzaty Hassan, Nurul Ebihara, Masahiro Ravindar, Lekkala Suhaily Saaidin, Aimi Yee Ling, Lau Hafizah Mukhtar, Nur Aqilah Zahirah Norazmi, Nur Ismail, Norzila |
Author_xml | – sequence: 1 givenname: Nur surname: Aqilah Zahirah Norazmi fullname: Aqilah Zahirah Norazmi, Nur organization: Department of Chemical Sciences, Faculty of Science & Technology, Universiti Kebangsaan Malaysia, 43600 Bangi, Selangor, Malaysia – sequence: 2 givenname: Nur surname: Hafizah Mukhtar fullname: Hafizah Mukhtar, Nur organization: Department of Chemical Sciences, Faculty of Science & Technology, Universiti Kebangsaan Malaysia, 43600 Bangi, Selangor, Malaysia – sequence: 3 givenname: Lekkala surname: Ravindar fullname: Ravindar, Lekkala organization: Department of Chemical Sciences, Faculty of Science & Technology, Universiti Kebangsaan Malaysia, 43600 Bangi, Selangor, Malaysia – sequence: 4 givenname: Aimi surname: Suhaily Saaidin fullname: Suhaily Saaidin, Aimi organization: Center of Foundation Studies, Universiti Teknologi Mara, 43800 Dengkil, Selangor, Malaysia – sequence: 5 givenname: Nurul surname: Huda Abd Karim fullname: Huda Abd Karim, Nurul organization: Department of Chemical Sciences, Faculty of Science & Technology, Universiti Kebangsaan Malaysia, 43600 Bangi, Selangor, Malaysia – sequence: 6 givenname: Amatul surname: Hamizah Ali fullname: Hamizah Ali, Amatul organization: Department of Chemical Sciences, Faculty of Science & Technology, Universiti Kebangsaan Malaysia, 43600 Bangi, Selangor, Malaysia – sequence: 7 givenname: Hani surname: Kartini Agustar fullname: Kartini Agustar, Hani organization: Department of Earth Sciences and Environment, Faculty of Science and Technology, Universiti Kebangsaan Malaysia, UKM, 43600, Bangi, Selangor, Malaysia – sequence: 8 givenname: Norzila surname: Ismail fullname: Ismail, Norzila organization: Department of Pharmacology, School of Medicinal Sciences, Universiti Sains Malaysia, 16150 Kubang Kerian, Kelantan, Malaysia – sequence: 9 givenname: Lau surname: Yee Ling fullname: Yee Ling, Lau organization: Department of Parasitology, Faculty of Medicine, Universiti Malaya, 50603 Kuala Lumpur, Malaysia – sequence: 10 givenname: Masahiro surname: Ebihara fullname: Ebihara, Masahiro organization: Department of Chemistry and Biomolecular Science, Faculty of Engineering, Gifu University, 1-1 Yanagido, Gifu City 501-1193, Japan – sequence: 11 givenname: Nurul surname: Izzaty Hassan fullname: Izzaty Hassan, Nurul email: drizz@ukm.edu.my organization: Department of Chemical Sciences, Faculty of Science & Technology, Universiti Kebangsaan Malaysia, 43600 Bangi, Selangor, Malaysia |
BackLink | https://www.ncbi.nlm.nih.gov/pubmed/38833991$$D View this record in MEDLINE/PubMed |
BookMark | eNp9kM1u1DAURi1URKeFN0AoSzYZrn_iJCyQ0KhApUpsYG05zvXUI8cebA9t3x6PUliysnzv-fzJ54pchBiQkLcUthSo_HDYTi7GtN8yYKKO-o7CC7KhMELLKIMLsgEQXctADpfkKucDAKWil6_IJR8GzseRbki6eTz6mFzYNzoUt2ivk9O-OcaC9a79x2YXw-G01-XM1D4d4oJFe-9Ms0SHxWFuHly5X5d1apPeLzWdGxtTg-FeB4Nzg9Y6o83Ta_LSap_xzfN5TX5-ufmx-9beff96u_t81xomaGkF7YScgNthlJaPk9CMjhPCYIdBWNYJPnAQtJ_4DMwKg3XXyUnrXshZG8mvyfv13WOKv06Yi1pcNui9DhhPWXGQYmRUdH1FxYqaFHNOaNUxVRfpSVFQZ9vqoFbb6mxbrbZr7N1zw2lacP4X-qu3Ap9WAOs_fztMKhuHZxsuoSlqju7_DX8AxK2WNw |
Cites_doi | 10.1021/om500622p 10.1016/j.jorganchem.2012.06.025 10.1021/acsomega.3c01830 10.3390/molecules24193604 10.1021/om300354x 10.1038/nm1586 10.1039/C7DT04142J 10.1039/c2dt12050j 10.1016/j.ejmech.2023.115458 10.1016/j.ejmech.2019.111791 10.1051/parasite/2018021 10.1371/journal.pmed.1000406 10.1002/adhm.202202411 10.1007/s00775-018-1634-9 10.1002/cbdv.202300158 10.1039/b924677k 10.1155/2020/9414093 10.1039/c3dt32740j 10.1039/c2dt12083f 10.3136/fstr.19.113 10.1128/AAC.00967-06 10.1128/microbiolspec.EI10-0013-2016 10.1016/j.jorganchem.2016.06.032 10.1021/om300334z 10.3390/ijms20010039 10.1021/om300392q 10.1016/j.molstruc.2014.12.070 10.3390/molecules13112900 10.1007/s00044-016-1509-y 10.1021/jm950729w 10.1016/S0968-0896(00)00206-6 10.1039/C7MT00196G 10.1016/j.bmc.2011.01.048 10.1016/S0140-6736(13)60024-0 10.1021/ar7000843 10.1002/cmdc.202300326 10.1007/s15010-024-02196-y 10.2147/IDR.S279433 10.1055/s-0031-1296211 10.1016/j.ejmech.2023.116043 10.1016/j.ejmech.2014.11.065 10.1017/S0031182016001153 10.1016/j.jinorgbio.2021.111408 10.1007/s00044-016-1769-6 10.1039/C5DT04918K 10.1016/j.ejmech.2020.112215 10.1016/j.eng.2018.11.011 10.1021/cr3001252 10.1016/j.ddtec.2019.06.001 10.1016/j.ejmech.2019.111963 10.1016/j.ejmech.2020.112694 10.1038/nature01813 10.1039/D3RA05361J 10.1038/s41570-017-0066 10.1021/jm400288z 10.1016/j.ejmech.2018.10.019 10.1021/jm301422h 10.1517/13543784.9.8.1815 10.1074/jbc.273.26.16192 10.1038/nrdp.2017.50 10.4269/ajtmh.15-0007 10.1016/j.jorganchem.2010.06.010 10.1039/D3DT02254D 10.1016/j.inoche.2023.111473 10.1016/j.jinorgbio.2022.111905 10.1016/j.cell.2011.03.049 10.1002/cbic.202000132 10.1016/j.jorganchem.2022.122419 10.1016/j.ccr.2018.04.008 10.3389/fmicb.2020.634640 10.1039/C5DT03739E 10.2174/1568026622666220105103751 10.1039/c3ra42513d 10.1016/j.bmcl.2017.12.057 10.1016/j.jorganchem.2022.122273 10.1021/jm300831b 10.1007/s00044-013-0748-4 10.1016/j.sajb.2019.11.017 10.1016/j.ejmech.2016.09.044 10.1039/C6MD00251J 10.1021/mp0500061 10.1515/pac-2018-0802 10.1016/j.ejphar.2021.174027 10.3389/fimmu.2019.01444 10.1021/jm9018383 10.1039/C5DT02378E 10.1039/C5DT02410B 10.1182/blood-2010-04-202911 10.1016/j.ejmech.2014.10.024 10.1016/0140-6736(93)90362-K 10.1155/2008/495123 10.1016/j.jinorgbio.2017.04.014 10.1016/j.inoche.2023.111674 10.1021/acs.inorgchem.0c01795 10.1002/chem.201801090 10.1128/AAC.05345-11 10.1038/nrmicro3138 10.3390/molecules25225276 10.1016/S1473-3099(21)00168-7 10.1039/D0DT01935F 10.1016/j.ejmech.2015.04.053 10.1016/S2666-5247(24)00016-8 10.1016/j.bmc.2007.07.012 10.1016/j.arabjc.2023.105573 10.1016/j.ejmech.2014.08.053 10.1016/j.inoche.2013.06.019 10.1039/C6DT03175G 10.1016/j.ejmech.2014.01.043 10.3390/molecules26051333 10.1016/j.jinorgbio.2020.111328 10.1039/c2dt30077j 10.1016/S1474-4422(05)70247-7 10.1016/bs.armc.2019.05.002 10.1021/om300945c 10.1021/jm100117e 10.1186/1756-3305-3-5 10.1016/j.jorganchem.2011.07.028 10.1039/C4DT03234A 10.1021/ic802220w 10.1056/NEJMra022219 10.1002/slct.202004710 10.1016/j.bmcl.2018.08.037 10.1016/j.ejmech.2023.115694 10.1002/cmdc.200700127 10.1016/j.jorganchem.2012.08.024 10.1021/acs.jmedchem.8b00760 10.1016/j.ejmech.2015.07.009 10.1016/j.jinorgbio.2011.03.019 10.1016/j.jorganchem.2013.02.024 10.1039/C9DT02030F 10.1016/j.ejmech.2019.06.069 10.1016/B978-008055232-3.62712-6 10.1016/j.ejps.2022.106365 10.1186/1475-2875-6-81 10.1016/j.ica.2022.121039 10.1021/jm970401y 10.1590/0074-02760150163 10.9734/ajrimps/2023/v12i1206 10.1016/j.jinorgbio.2018.11.018 10.1016/j.jorganchem.2013.04.017 10.1002/chem.201904699 |
ContentType | Journal Article |
Copyright | 2024 Elsevier Inc. Copyright © 2024 Elsevier Inc. All rights reserved. |
Copyright_xml | – notice: 2024 Elsevier Inc. – notice: Copyright © 2024 Elsevier Inc. All rights reserved. |
DBID | CGR CUY CVF ECM EIF NPM AAYXX CITATION 7X8 |
DOI | 10.1016/j.bioorg.2024.107510 |
DatabaseName | Medline MEDLINE MEDLINE (Ovid) MEDLINE MEDLINE PubMed CrossRef MEDLINE - Academic |
DatabaseTitle | MEDLINE Medline Complete MEDLINE with Full Text PubMed MEDLINE (Ovid) CrossRef MEDLINE - Academic |
DatabaseTitleList | MEDLINE - Academic MEDLINE |
Database_xml | – sequence: 1 dbid: NPM name: PubMed url: https://proxy.k.utb.cz/login?url=http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed sourceTypes: Index Database – sequence: 2 dbid: EIF name: MEDLINE url: https://proxy.k.utb.cz/login?url=https://www.webofscience.com/wos/medline/basic-search sourceTypes: Index Database |
DeliveryMethod | fulltext_linktorsrc |
Discipline | Anatomy & Physiology Chemistry |
EISSN | 1090-2120 |
ExternalDocumentID | 10_1016_j_bioorg_2024_107510 38833991 S0045206824004152 |
Genre | Journal Article Review |
GroupedDBID | --- --K --M -DZ -~X .GJ .~1 0R~ 1B1 1RT 1~. 1~5 23N 4.4 457 4G. 53G 5GY 5VS 7-5 71M 8P~ 9JM 9JN AAAJQ AACTN AAEDT AAEDW AAIAV AAIKJ AAKOC AALRI AAOAW AAQFI AAQXK AARKO AARLI AAXUO ABEFU ABGSF ABJNI ABMAC ABUDA ABXDB ABZDS ACDAQ ACGFS ACNCT ACNNM ACRLP ADBBV ADECG ADEZE ADFGL ADMUD ADUVX AEBSH AEHWI AEKER AENEX AFKWA AFTJW AFXIZ AFZHZ AGEKW AGHFR AGRDE AGUBO AGYEJ AHHHB AIEXJ AIKHN AITUG AJOXV AJSZI AKRWK ALCLG ALMA_UNASSIGNED_HOLDINGS AMFUW AMRAJ ASPBG AVWKF AXJTR AZFZN BKOJK BLXMC CAG CJTIS COF CS3 DM4 DU5 EBS EFBJH EJD EO8 EO9 EP2 EP3 F5P FA8 FDB FEDTE FGOYB FIRID FLBIZ FNPLU FYGXN G-2 G-Q GBLVA HLW HMG HMS HMT HVGLF HZ~ H~9 IHE J1W K-O KOM LG5 LUGTX LX2 LZ5 M2Y M33 M41 MO0 MVM N9A O-L O9- OAUVE OGGZJ OZT P-8 P-9 P2P PC. Q38 R2- RIG RNS ROL RPZ SBG SCB SDF SDG SDP SES SEW SIN SOC SPC SPCBC SPT SSI SSK SSP SSU SSZ T5K UQL WH7 WUQ XPP ZGI ZMT ~G- ~KM AAXKI AFJKZ CGR CUY CVF ECM EIF NPM AAYXX CITATION 7X8 |
ID | FETCH-LOGICAL-c241t-41546b03f896f39b4a219be08f884f2543830417b3d02f4cebe056baa746dac63 |
IEDL.DBID | AIKHN |
ISSN | 0045-2068 1090-2120 |
IngestDate | Sat Aug 17 04:41:27 EDT 2024 Thu Sep 26 16:12:15 EDT 2024 Wed Oct 23 10:01:50 EDT 2024 Tue Jun 18 08:50:49 EDT 2024 |
IsPeerReviewed | true |
IsScholarly | true |
Keywords | Molecular hybridization Antimalarial PQ ARS INH ART SAR CHO FQ Fc QN WHO LSG CQS CQDP CQR TSCs Organometallic Transition metal SERM CP CQ ECM DHODH HEK AQ ACT MMV PGM ROS CORM PfCRT Conjugation ARM DHA PTA |
Language | English |
License | Copyright © 2024 Elsevier Inc. All rights reserved. |
LinkModel | DirectLink |
MergedId | FETCHMERGED-LOGICAL-c241t-41546b03f896f39b4a219be08f884f2543830417b3d02f4cebe056baa746dac63 |
Notes | ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 ObjectType-Review-3 content type line 23 |
PMID | 38833991 |
PQID | 3064921457 |
PQPubID | 23479 |
ParticipantIDs | proquest_miscellaneous_3064921457 crossref_primary_10_1016_j_bioorg_2024_107510 pubmed_primary_38833991 elsevier_sciencedirect_doi_10_1016_j_bioorg_2024_107510 |
PublicationCentury | 2000 |
PublicationDate | 2024-08-01 |
PublicationDateYYYYMMDD | 2024-08-01 |
PublicationDate_xml | – month: 08 year: 2024 text: 2024-08-01 day: 01 |
PublicationDecade | 2020 |
PublicationPlace | United States |
PublicationPlace_xml | – name: United States |
PublicationTitle | Bioorganic chemistry |
PublicationTitleAlternate | Bioorg Chem |
PublicationYear | 2024 |
Publisher | Elsevier Inc |
Publisher_xml | – name: Elsevier Inc |
References | Meena, Kumar Baroliya (b0140) 2023; 20 Macedo, Villarreal, Couto, Moreira, Navarro, Machado, Prudêncio, Batista, Soares (b0315) 2017; 9 Kumar, Devi, Dubey, Tufail, Sharma (b0630) 2024; 159 Dive, Biot (b0215) 2008; 3 Shibeshi, Kifle, Atnafie (b0035) 2020; 13 Peter, Morifi, Aderibigbe (b0440) 2021; 6 Rosenthal (b0415) 2021; 21 Norman, Hambley (b0115) 2011 Baartzes, Stringer, Smith (b0180) 2018 Macedo, Colina-Vegas, Da Paixão, Navarro, Barreto, Oliveira, Macambira, Machado, Prudêncio, D’alessandro, Basilico, Moreira, Batista, Soares (b0360) 2016; 143 Cui, Mharakurwa, Ndiaye, Rathod, Rosenthal (b0070) 2015; 93 Smit, Bezuidenhout, Bezuidenhout, N’Da (b0695) 2016; 25 Ravindar, Hasbullah, Rakesh, Raheem, Agustar, Ismail, Ling, Hassan (b0095) 2024; 264 Alonso, Bassat, Binka, Brewer, Chandra, Culpepper, Dinglasan, Duncan, Duparc, Fukuda, Laxminarayan, MacArthur, Magill, Marzetta, Milman, Mutabingwa, Nosten, Nwaka, Nyunt, Ohrt, Plowe, Pottage, Price, Ringwald, Serazin, Shanks, Sinden, Tanner, Vial, Ward, Wellems, Wells, White, Wirth, Yeung, Yuthavong, Alonso, Djimde, Magill, Milman, Nájera, Plowe, Wells, Yeung, Kremsner, Mueller, Newman, Rabinovich (b0775) 2011; 8 Medicines for Malaria Venture, ZY19489-Ferroquine, (2024). https://www.mmv.org/mmv-pipeline-antimalarial-drugs/zy19489-ferroquine (accessed April 25, 2024). Delhaes, Biot, Berry, Maciejewski, Camus, Brocard, Dive (b0420) 2000; 8 Ong, Gasser (b0205) 2020; 37 Martínez, Deregnaucourt, Sinou, Latour, Roy, Schrével, Sánchez-Delgado (b0550) 2017; 26 Aksic, Gencic, Radulovic (b0725) 2020; 18 Cox (b0005) 2010; 3 Benoit-Vical, Lelièvre, Berry, Deymier, Dechy-Cabaret, Cazelles, Loup, Robert, Magnaval, Meunier (b0780) 2007; 51 Adams, de Kock, Smith, Land, Liu, Hopper, Hsiao, Burgoyne, Stringer, Meyer, Wiesner, Chibale, Smith (b0605) 2015; 44 Buffet, Safeukui, Deplaine, Brousse, Prendki, Thellier, Turner, Mercereau-Puijalon (b0045) 2011; 117 Chellan, Sadler (b0190) 2020; 26 Mbaba, Dingle, Zulu, Laming, Swart, de la Mare, Hoppe, Edkins, Khanye (b0530) 2021; 26 Hien, White (b0740) 1993; 341 Mbaba, de la Mare, Sterrenberg, Kajewole, Maharaj, Edkins, Isaacs, Hoppe, Khanye (b0495) 2019; 24 Riggs, Hartmann (b0465) 2003; 348 Adams, De Kock, Smith, Malatji, Hutton, Chibale, Smith (b0590) 2013; 739 Chellan, Nasser, Vivas, Chibale, Smith (b0595) 2010; 695 Chellan, Avery, Duffy, Land, Tam, Kim, Cheng, Romero-Canelón, Sadler (b0455) 2021; 219 Noronha, Pawar, Prajapati, Subramanian (b0065) 2020; 128 Sánchez-Delgado, Navarro, Pérez, Urbina (b0125) 1996; 39 Abid, Singh, Egan, Joshi (b0185) 2022; 22 Ferreira, Marguti, Bechmann, Jeney, Chora, Palha, Rebelo, Henri, Beuzard, Soares (b0380) 2011; 145 Gemma, Camodeca, Brindisi, Brogi, Kukreja, Kunjir, Gabellieri, Lucantoni, Habluetzel, Taramelli, Basilico, Gualdani, Tadini-Buoninsegni, Bartolommei, Moncelli, Martin, Summers, Lamponi, Savini, Fiorini, Valoti, Novellino, Campiani, Butini (b0535) 2012; 55 Ravindar, Hasbullah, Rakesh, Hassan (b0085) 2023; 256 Thatikayala, Kumar Garige, Gadegoni (b0640) 2022 Chutiyami, Saravanakumar, Bello, Salihu, Adeleye, Kolo, Dawa, Hamina, Bhandari, Sulaiman, Sim (b0080) 2024 Herrmann, Salas, Patrick, de Kock, Smith, Adam, Orvig (b0285) 2012; 41 Herrmann, Salas, Cawthray, de Kock, Patrick, Smith, Adam, Orvig (b0290) 2012; 31 Xiao, Sun, Kong, Gao (b0230) 2020; 185 Mehta, Gajera, Raval, Thakkar, Patel (b0355) 2016; 7 Attar, O’Brien, Alhaddad, Golden, Calderón-Urrea (b0690) 2011; 19 Rohde, Sorci (b0485) 2021; 11 Salas, Herrmann, Cawthray, Nimphius, Kenkel, Chen, de Kock, Smith, Patrick, Adam, Orvig (b0260) 2013; 56 Sevrioukova, Poulos (b0460) 2013; 56 Adebayo, Oduselu, Aderohunmu, Klika, Olasehinde, Ajani, Adebiyi (b0100) 2024; 17 Proschak, Stark, Merk (b0715) 2019; 62 Yadav, Sharma, Awasthi (b0770) 2014; 4 Peter, Aderibigbe (b0160) 2019; 24 Biot, Taramelli, Forfar-Bares, Maciejewski, Boyce, Nowogrocki, Brocard, Basilico, Olliaro, Egan (b0200) 2005; 2 Patti, Pedotti, Grassi, Idolo, Guido, De Donno (b0305) 2012; 716 Colina-Vegas, da Cruz, Silva, de Souza Pereira, Isis Barros, Araújo Nobrega, Navarro, Rottmann, D’Alessandro, Basilico, Azevedo Batista, Moreira (b0370) 2023; 29 Montes-González, Alsina-Sánchez, Aponte-Santini, Delgado-Rivera, Durán-Camacho (b0680) 2019; 91 Idro, Jenkins, Newton (b0395) 2005; 4 Herrmann, Salas, Patrick, de Kock, Smith, Adam, Orvig (b0295) 2012; 31 Mahapatra, Hazra (b0635) 2023 Ekengard, Kumar, Fogeron, de Kock, Smith, Haukka, Monari, Nordlander (b0350) 2016; 45 Blackie, Chibale (b0225) 2008; 2008 Glans, Taylor, De Kock, Smith, Haukka, Moss, Nordlander (b0330) 2011; 105 Adams, Stringer, de Kock, Smith, Land, Liu, Tam, Cheng, Njoroge, Chibale, Smith (b0280) 2016; 45 Pamplona, Ferreira, Balla, Jeney, Balla, Epiphanio, Chora, Rodrigues, Gregoire, Cunha-Rodrigues, Portugal, Soares, Mota (b0390) 2007; 13 Baartzes, Stringer, Seldon, Warner, Taylor, Wittlin, Chibale, Smith (b0545) 2019; 180 Reiter, Fröhlich, Zeino, Marschall, Bahsi, Leidenberger, Friedrich, Kappes, Hampel, Efferth, Tsogoeva (b0435) 2015; 97 Salas, Herrmann, Orvig (b0030) 2013; 113 Albertyn, van Niekerk, Duffy, Avery, Strauss, Chellan (b0445) 2023; 987–988 Ravindar, Hasbullah, Rakesh, Hassan (b0090) 2023; 259 Dubar, Khalife, Brocard, Dive, Biot (b0730) 2008; 13 Caraballo, King (b0015) 2014; 16 Venkatesan (b0025) 2024; 5 Eckstein-Ludwig, Webb, van Goethem, East, Lee, Kimura, O’Neill, Bray, Ward, Krishna (b0755) 2003; 424 Kwofie, Broni, Dankwa, Enninful, Teye, Davidson, Nimely, Chioma Orizu, Kempaiah, Rathi, Miller (b0150) 2020; 2020 Price (b0735) 2000; 9 Kumar, Pradines, Madamet, Amalvict, Benoit, Kumar (b0520) 2014; 87 N’Da, Smith (b0255) 2014; 23 Arancibia, Dubar, Pradines, Forfar, Dive, Klahn, Biot (b0325) 2010; 18 Bellot, Coslédan, Vendier, Brocard, Meunier, Robert (b0505) 2010; 53 Reiter, Çapcı Karagöz, Fröhlich, Klein, Zeino, Viertel, Held, Mordmüller, Emirdağ Öztürk, Anıl, Efferth, Tsogoeva (b0525) 2014; 75 Hubin, Amoyaw, Roewe, Simpson, Maples, Carder Freeman, Cain, Le, Archibald, Khan, Tekwani, Khan (b0120) 2014; 22 Mandal, Kushwaha, Mandal, Bajpai, Yadav, Banerjee (b0155) 2023; 18 Ekengard, Glans, Cassells, Fogeron, Govender, Stringer, Chellan, Lisensky, Hersh, Doverbratt, Lidin, de Kock, Smith, Smith, Nordlander (b0345) 2015; 44 Wani, Jameel, Baig, Mumtazuddin, Hun (b0170) 2015; 101 World Health Organization (WHO), World Malaria Report 2023, Geneva, 2023. https://www.who.int/teams/global-malaria-programme/reports/world-malaria-report-2023. Qin, Zhang, Lekkala, Alsulami, Rakesh (b0670) 2020; 193 Stringer, Quintero, Wiesner, Smith, Nordlander (b0555) 2019; 191 Chellan, Avery, Duffy, Triccas, Nagalingam, Tam, Cheng, Liu, Land, Clarkson, Romero-Canelón, Sadler (b0480) 2018; 24 Flannery, Chatterjee, Winzeler (b0060) 2013; 11 Farrer, Sadler (b0110) 2011 Wenzel, Chavain, Wang, Friebolin, Maes, Pradines, Lanzer, Yardley, Brun, Herold-Mende, Biot, Tóth, Davioud-Charvet (b0245) 2010; 53 Ouji, Augereau, Paloque, Benoit-Vical (b0410) 2018; 25 Glans, Hu, Jöst, de Kock, Smith, Haukka, Bruhn, Schatzschneider, Nordlander (b0335) 2012; 41 Lee, Russell, Rénia (b0055) 2019; 10 Matos, Da Cruz, Cabrita, Gut, Nogueira, Do Rosário, Moreira, Rosenthal, Prudêncio, Gomes (b0310) 2012; 56 Barends, Jaidee, Khaohirun, Singhasivanon, Nosten (b0195) 2007; 6 Da, Breytenbach, Smith, Lategan (b0250) 2011; 61 Adams, Li, Khot, De Kock, Smith, Land, Chibale, Smith (b0585) 2013; 42 Fairhurst, Dondorp (b0075) 2016; 4 Ishmail, Melis, Mbaba, Smith (b0400) 2021; 215 Adams, Barnard, de Kock, Smith, Wiesner, Chibale, Smith (b0610) 2016; 45 Oyarzo, Acuña, Klahn, Arancibia, Silva, Bosque, López, Font-Bardía, Calvis, Messeguer (b0320) 2018; 47 Biot, Glorian, Maciejewski, Brocard, Domarle, Blampain, Millet, Georges, Abessolo, Dive, Lebibi (b0240) 1997; 40 Munnik, Kaschula, Watson, Wiesner, Loots, Chellan (b0665) 2022; 540 Li, de Kock, Smith, Chibale, Smith (b0275) 2014; 33 Sovari, Golding, Mbaba, Mohunlal, Egan, Smith, Zobi (b0405) 2022; 234 Devi, Kumar, Dubey, Tufail, Boora (b0625) 2023 Alsina-Sánchez, Montalvo-Vázquez, Grafals-Ruiz, Acosta, Ormé, Rodríguez, Delgado-Rivera, Tinoco, Dharmawardhane, Montes-González (b0685) 2023; 8 E.M. Scholar, Tamoxifen, in: S.J. Enna, D.B. Bylund (Eds.), XPharm Compr. Pharmacol. Ref., Elsevier, 2010: pp. 1–8. https://doi.org/10.1016/B978-008055232-3.62712-6. Bhisutthibhan, Pan, Hossler, Walker, Yowell, Carlton, Dame, Meshnick (b0750) 1998; 273 White, Pukrittayakamee, Hien, Faiz, Mokuolu, Dondorp (b0050) 2014; 383 Munnik, Kaschula, Harding, Chellan (b0450) 2023; 52 Blackie, Beagley, Croft, Kendrick, Moss, Chibale (b0220) 2007; 15 Ravindar, Hasbullah, Rakesh, Hassan (b0105) 2023; 183 Toro, Klahn, Pradines, Lahoz, Pascual, Biot, Arancibia (b0650) 2013; 35 Stringer, Taylor, Guzgay, Shokar, Au, Smith, Hendricks, Land, Egan, Smith (b0375) 2015; 44 Taxak, Devi, Kumar, Asija (b0145) 2023; 158 Baartzes, Jordaan, Warner, Combrinck, Taylor, Chibale, Smith (b0565) 2020; 206 Rylands, Welsh, Maepa, Stringer, Taylor, Chibale, Smith (b0655) 2019; 161 Arancibia, Biot, Delaney, Roussel, Pascual, Pradines, Klahn (b0700) 2013; 723 Tseha (b0040) 2021 Baartzes, Combrinck, Chibale, Smith (b0570) 2022; 975 Mbaba, Golding, Smith (b0175) 2020; 25 de Souza, Aguiar, de Oliveira, Top, Pigeon, Jaouen, Goulart, Krettli (b0475) 2015; 110 Baartzes, Stringer, Okombo, Seldon, Warner, de Kock, Smith, Smith (b0620) 2016; 819 Milheiro, Gonçalves, Lopes, Madureira, Lobo, Lopes, Nogueira, Fontinha, Prudêncio, Piedade, Pinto, Florindo, Moreira (b0710) 2020; 59 Phillips, Burrows, Manyando, van Huijsduijnen, Van Voorhis, Wells (b0010) 2017; 3 Patra, Gasser (b0720) 2017; 1 Adams, de Kock, Smith, Chibale, Smith (b0600) 2013; 736 Khanye, Gut, Rosenthal, Chibale, Smith (b0615) 2011; 696 Li, de Kock, Smith, Guzgay, Hendricks, Naran, Mizrahi, Warner, Chibale, Smith (b0270) 2013; 32 Kowalski (b0165) 2018; 366 Biot, Dive (b0210) 2010 Jordaan, Ndlovu, Mkhize, Ngubane, Loots, Duffy, Avery, Chellan (b0660) 2022; 962 de Lange, Coertzen, Smit, Wentzel, Wong, Birkholtz, Haynes, N’Da (b0430) 2018; 28 Fricker (b0580) 2010; 2 Singh, Gut, Rosenthal, Kumar (b0510) 2017; 125 Glans, Ehnbom, de Kock, Martínez, Estrada, Smith, Eckstein-Ludwig (10.1016/j.bioorg.2024.107510_b0755) 2003; 424 Sevrioukova (10.1016/j.bioorg.2024.107510_b0460) 2013; 56 Qin (10.1016/j.bioorg.2024.107510_b0670) 2020; 193 de Lange (10.1016/j.bioorg.2024.107510_b0425) 2018; 28 Flannery (10.1016/j.bioorg.2024.107510_b0060) 2013; 11 Chellan (10.1016/j.bioorg.2024.107510_b0455) 2021; 219 Salas (10.1016/j.bioorg.2024.107510_b0030) 2013; 113 Stringer (10.1016/j.bioorg.2024.107510_b0555) 2019; 191 Reiter (10.1016/j.bioorg.2024.107510_b0435) 2015; 97 Mahapatra (10.1016/j.bioorg.2024.107510_b0635) 2023 Lee (10.1016/j.bioorg.2024.107510_b0055) 2019; 10 Glans (10.1016/j.bioorg.2024.107510_b0340) 2012; 41 Farrer (10.1016/j.bioorg.2024.107510_b0110) 2011 Attar (10.1016/j.bioorg.2024.107510_b0690) 2011; 19 Biot (10.1016/j.bioorg.2024.107510_b0210) 2010 10.1016/j.bioorg.2024.107510_b0130 Singh (10.1016/j.bioorg.2024.107510_b0510) 2017; 125 Adams (10.1016/j.bioorg.2024.107510_b0600) 2013; 736 Meena (10.1016/j.bioorg.2024.107510_b0140) 2023; 20 Choudhary (10.1016/j.bioorg.2024.107510_b0645) 2021; 899 Martínez (10.1016/j.bioorg.2024.107510_b0550) 2017; 26 Ravindar (10.1016/j.bioorg.2024.107510_b0090) 2023; 259 Alsina-Sánchez (10.1016/j.bioorg.2024.107510_b0685) 2023; 8 Fairhurst (10.1016/j.bioorg.2024.107510_b0075) 2016; 4 Oyarzo (10.1016/j.bioorg.2024.107510_b0320) 2018; 47 Kwofie (10.1016/j.bioorg.2024.107510_b0150) 2020; 2020 Patra (10.1016/j.bioorg.2024.107510_b0720) 2017; 1 Mbaba (10.1016/j.bioorg.2024.107510_b0175) 2020; 25 Chiang (10.1016/j.bioorg.2024.107510_b0385) 2018; 20 Ferreira (10.1016/j.bioorg.2024.107510_b0380) 2011; 145 Melis (10.1016/j.bioorg.2024.107510_b0560) 2020; 49 Norman (10.1016/j.bioorg.2024.107510_b0115) 2011 N’Da (10.1016/j.bioorg.2024.107510_b0255) 2014; 23 Bhisutthibhan (10.1016/j.bioorg.2024.107510_b0750) 1998; 273 Alonso (10.1016/j.bioorg.2024.107510_b0775) 2011; 8 10.1016/j.bioorg.2024.107510_b0020 Smit (10.1016/j.bioorg.2024.107510_b0695) 2016; 25 Ekengard (10.1016/j.bioorg.2024.107510_b0350) 2016; 45 Sovari (10.1016/j.bioorg.2024.107510_b0405) 2022; 234 Adams (10.1016/j.bioorg.2024.107510_b0590) 2013; 739 Venkatesan (10.1016/j.bioorg.2024.107510_b0025) 2024; 5 Li (10.1016/j.bioorg.2024.107510_b0275) 2014; 33 Arancibia (10.1016/j.bioorg.2024.107510_b0700) 2013; 723 Zhang (10.1016/j.bioorg.2024.107510_b0500) 2013; 19 Chellan (10.1016/j.bioorg.2024.107510_b0190) 2020; 26 Chellan (10.1016/j.bioorg.2024.107510_b0575) 2012; 31 Herrmann (10.1016/j.bioorg.2024.107510_b0285) 2012; 41 Yadav (10.1016/j.bioorg.2024.107510_b0770) 2014; 4 Adams (10.1016/j.bioorg.2024.107510_b0610) 2016; 45 Wang (10.1016/j.bioorg.2024.107510_b0745) 2019; 5 Benoit-Vical (10.1016/j.bioorg.2024.107510_b0780) 2007; 51 Mandal (10.1016/j.bioorg.2024.107510_b0155) 2023; 18 Shibeshi (10.1016/j.bioorg.2024.107510_b0035) 2020; 13 Kumari (10.1016/j.bioorg.2024.107510_b0135) 2023; 12 Herrmann (10.1016/j.bioorg.2024.107510_b0295) 2012; 31 Bellot (10.1016/j.bioorg.2024.107510_b0505) 2010; 53 Barends (10.1016/j.bioorg.2024.107510_b0195) 2007; 6 Li (10.1016/j.bioorg.2024.107510_b0270) 2013; 32 Blackie (10.1016/j.bioorg.2024.107510_b0220) 2007; 15 Minić (10.1016/j.bioorg.2024.107510_b0300) 2020; 187 Biot (10.1016/j.bioorg.2024.107510_b0240) 1997; 40 Chellan (10.1016/j.bioorg.2024.107510_b0480) 2018; 24 White (10.1016/j.bioorg.2024.107510_b0050) 2014; 383 10.1016/j.bioorg.2024.107510_b0470 Xiao (10.1016/j.bioorg.2024.107510_b0230) 2020; 185 Syahri (10.1016/j.bioorg.2024.107510_b0675) 2023; 13 Tseha (10.1016/j.bioorg.2024.107510_b0040) 2021 Thatikayala (10.1016/j.bioorg.2024.107510_b0640) 2022 Arancibia (10.1016/j.bioorg.2024.107510_b0325) 2010; 18 Adebayo (10.1016/j.bioorg.2024.107510_b0100) 2024; 17 Macedo (10.1016/j.bioorg.2024.107510_b0360) 2016; 143 Hubin (10.1016/j.bioorg.2024.107510_b0120) 2014; 22 Rosenthal (10.1016/j.bioorg.2024.107510_b0415) 2021; 21 Rohde (10.1016/j.bioorg.2024.107510_b0485) 2021; 11 Ravindar (10.1016/j.bioorg.2024.107510_b0105) 2023; 183 Reiter (10.1016/j.bioorg.2024.107510_b0525) 2014; 75 Gemma (10.1016/j.bioorg.2024.107510_b0535) 2012; 55 Peter (10.1016/j.bioorg.2024.107510_b0160) 2019; 24 Baartzes (10.1016/j.bioorg.2024.107510_b0565) 2020; 206 Colina-Vegas (10.1016/j.bioorg.2024.107510_b0370) 2023; 29 Jordaan (10.1016/j.bioorg.2024.107510_b0660) 2022; 962 Ravindar (10.1016/j.bioorg.2024.107510_b0085) 2023; 256 Mbaba (10.1016/j.bioorg.2024.107510_b0540) 2020; 21 Baartzes (10.1016/j.bioorg.2024.107510_b0545) 2019; 180 Proschak (10.1016/j.bioorg.2024.107510_b0715) 2019; 62 Da (10.1016/j.bioorg.2024.107510_b0250) 2011; 61 Ravindar (10.1016/j.bioorg.2024.107510_b0095) 2024; 264 Abid (10.1016/j.bioorg.2024.107510_b0185) 2022; 22 Salas (10.1016/j.bioorg.2024.107510_b0260) 2013; 56 Herrmann (10.1016/j.bioorg.2024.107510_b0290) 2012; 31 Adams (10.1016/j.bioorg.2024.107510_b0585) 2013; 42 Blackie (10.1016/j.bioorg.2024.107510_b0225) 2008; 2008 Pamplona (10.1016/j.bioorg.2024.107510_b0390) 2007; 13 Kowalski (10.1016/j.bioorg.2024.107510_b0165) 2018; 366 Biot (10.1016/j.bioorg.2024.107510_b0200) 2005; 2 Stringer (10.1016/j.bioorg.2024.107510_b0375) 2015; 44 Ouji (10.1016/j.bioorg.2024.107510_b0410) 2018; 25 Chellan (10.1016/j.bioorg.2024.107510_b0595) 2010; 695 Riggs (10.1016/j.bioorg.2024.107510_b0465) 2003; 348 Baartzes (10.1016/j.bioorg.2024.107510_b0180) 2018 Aksic (10.1016/j.bioorg.2024.107510_b0725) 2020; 18 Gupta (10.1016/j.bioorg.2024.107510_b0760) 2019 Phillips (10.1016/j.bioorg.2024.107510_b0010) 2017; 3 Munnik (10.1016/j.bioorg.2024.107510_b0665) 2022; 540 Peter (10.1016/j.bioorg.2024.107510_b0440) 2021; 6 Albertyn (10.1016/j.bioorg.2024.107510_b0445) 2023; 987–988 Hien (10.1016/j.bioorg.2024.107510_b0740) 1993; 341 Cui (10.1016/j.bioorg.2024.107510_b0070) 2015; 93 Mbaba (10.1016/j.bioorg.2024.107510_b0490) 2017; 172 Caraballo (10.1016/j.bioorg.2024.107510_b0015) 2014; 16 Kumar (10.1016/j.bioorg.2024.107510_b0630) 2024; 159 Patti (10.1016/j.bioorg.2024.107510_b0305) 2012; 716 Noronha (10.1016/j.bioorg.2024.107510_b0065) 2020; 128 Meunier (10.1016/j.bioorg.2024.107510_b0765) 2008; 41 Stringer (10.1016/j.bioorg.2024.107510_b0365) 2019; 48 Fricker (10.1016/j.bioorg.2024.107510_b0580) 2010; 2 Khanye (10.1016/j.bioorg.2024.107510_b0615) 2011; 696 Mbaba (10.1016/j.bioorg.2024.107510_b0530) 2021; 26 de Souza (10.1016/j.bioorg.2024.107510_b0475) 2015; 110 Adams (10.1016/j.bioorg.2024.107510_b0280) 2016; 45 Idro (10.1016/j.bioorg.2024.107510_b0395) 2005; 4 Dive (10.1016/j.bioorg.2024.107510_b0215) 2008; 3 Ong (10.1016/j.bioorg.2024.107510_b0205) 2020; 37 Devi (10.1016/j.bioorg.2024.107510_b0625) 2023 Buffet (10.1016/j.bioorg.2024.107510_b0045) 2011; 117 Rylands (10.1016/j.bioorg.2024.107510_b0655) 2019; 161 Macedo (10.1016/j.bioorg.2024.107510_b0315) 2017; 9 Chutiyami (10.1016/j.bioorg.2024.107510_b0080) 2024 Mwande-Maguene (10.1016/j.bioorg.2024.107510_b0265) 2015; 90 Toro (10.1016/j.bioorg.2024.107510_b0650) 2013; 35 Price (10.1016/j.bioorg.2024.107510_b0735) 2000; 9 Sánchez-Delgado (10.1016/j.bioorg.2024.107510_b0125) 1996; 39 Taxak (10.1016/j.bioorg.2024.107510_b0145) 2023; 158 Munnik (10.1016/j.bioorg.2024.107510_b0450) 2023; 52 Glans (10.1016/j.bioorg.2024.107510_b0335) 2012; 41 Glans (10.1016/j.bioorg.2024.107510_b0330) 2011; 105 Kumar (10.1016/j.bioorg.2024.107510_b0520) 2014; 87 Cox (10.1016/j.bioorg.2024.107510_b0005) 2010; 3 Dubar (10.1016/j.bioorg.2024.107510_b0730) 2008; 13 Montes-González (10.1016/j.bioorg.2024.107510_b0680) 2019; 91 Ekengard (10.1016/j.bioorg.2024.107510_b0345) 2015; 44 Milheiro (10.1016/j.bioorg.2024.107510_b0710) 2020; 59 Baartzes (10.1016/j.bioorg.2024.107510_b0620) 2016; 819 Mbaba (10.1016/j.bioorg.2024.107510_b0495) 2019; 24 de Lange (10.1016/j.bioorg.2024.107510_b0430) 2018; 28 Rajapakse (10.1016/j.bioorg.2024.107510_b0235) 2009; 48 Wani (10.1016/j.bioorg.2024.107510_b0170) 2015; 101 Ishmail (10.1016/j.bioorg.2024.107510_b0400) 2021; 215 Adams (10.1016/j.bioorg.2024.107510_b0605) 2015; 44 Mehta (10.1016/j.bioorg.2024.107510_b0355) 2016; 7 Delhaes (10.1016/j.bioorg.2024.107510_b0420) 2000; 8 Mishra (10.1016/j.bioorg.2024.107510_b0705) 2015; 1085 Kumar (10.1016/j.bioorg.2024.107510_b0515) 2014; 86 Wenzel (10.1016/j.bioorg.2024.107510_b0245) 2010; 53 Matos (10.1016/j.bioorg.2024.107510_b0310) 2012; 56 Baartzes (10.1016/j.bioorg.2024.107510_b0570) 2022; 975 |
References_xml | – volume: 2008 start-page: 1 year: 2008 end-page: 10 ident: b0225 article-title: Metallocene antimalarials: the continuing quest publication-title: Met. Based. Drugs. contributor: fullname: Chibale – volume: 113 start-page: 3450 year: 2013 end-page: 3492 ident: b0030 article-title: Metalloantimalarials publication-title: Chem. Rev. contributor: fullname: Orvig – volume: 736 start-page: 19 year: 2013 end-page: 26 ident: b0600 article-title: Synthesis, characterization and antiplasmodial evaluation of cyclopalladated thiosemicarbazone complexes publication-title: J. Organomet. Chem. contributor: fullname: Smith – volume: 44 start-page: 14906 year: 2015 end-page: 14917 ident: b0375 article-title: Polyamine quinoline rhodium complexes: synthesis and pharmacological evaluation as antiparasitic agents against Plasmodium falciparum and Trichomonas vaginalis publication-title: Dalt. Trans. contributor: fullname: Smith – volume: 158 year: 2023 ident: b0145 article-title: Exploring the antimalarial, antioxidant and antimicrobial properties of newly synthesized diorganotin(IV) complexes with ONO-donor hydrazone ligands publication-title: Inorg. Chem. Commun. contributor: fullname: Asija – volume: 24 start-page: 139 year: 2019 end-page: 149 ident: b0495 article-title: Novobiocin–ferrocene conjugates possessing anticancer and antiplasmodial activity independent of HSP90 inhibition publication-title: J. Biol. Inorg. Chem. contributor: fullname: Khanye – volume: 975 year: 2022 ident: b0570 article-title: Heteroleptic Rh(III) phenylpyridyl complexes based on an aminoquinoline-benzimidazole hybrid scaffold: Antiplasmodial evaluation and mechanistic insights publication-title: J. Organomet. Chem. contributor: fullname: Smith – volume: 37 start-page: 117 year: 2020 end-page: 124 ident: b0205 article-title: Organometallic compounds in drug discovery: Past, present and future publication-title: Drug Discov. Today Technol. contributor: fullname: Gasser – volume: 12 year: 2023 ident: b0135 article-title: Development of mitochondria targeting AIE-active cyclometalated iridium complexes as potent antimalarial agents publication-title: Adv. Healthc. Mater. contributor: fullname: Sasmal – volume: 19 start-page: 2055 year: 2011 end-page: 2073 ident: b0690 article-title: Ferrocenyl chalcones versus organic chalcones: A comparative study of their nematocidal activity publication-title: Bioorg. Med. Chem. contributor: fullname: Calderón-Urrea – volume: 20 year: 2023 ident: b0140 article-title: Synthesis, characterization, antimicrobial and antimalarial activities of azines based schiff bases and their Pd(II) complexes publication-title: Chem. Biodivers. contributor: fullname: Kumar Baroliya – volume: 31 start-page: 5748 year: 2012 end-page: 5759 ident: b0295 article-title: Modular synthesis of 1,2- and 1,1′-disubstituted ferrocenyl carbohydrate chloroquine and mefloquine conjugates as potential antimalarial agents publication-title: Organometallics. contributor: fullname: Orvig – start-page: 49 year: 2011 end-page: 78 ident: b0115 article-title: Targeting strategies for metal-based therapeutics publication-title: Bioinorg. Med. Chem. contributor: fullname: Hambley – volume: 24 start-page: 3604 year: 2019 ident: b0160 article-title: Ferrocene-based compounds with antimalaria/anticancer activity publication-title: Molecules. contributor: fullname: Aderibigbe – volume: 20 start-page: 39 year: 2018 ident: b0385 article-title: A Dual Role of Heme Oxygenase-1 in Cancer Cells publication-title: Int. J. Mol. Sci. contributor: fullname: Chang – volume: 19 start-page: 113 year: 2013 end-page: 116 ident: b0500 article-title: Oleanolic acid and ursolic acid in commercial dried fruits publication-title: Food Sci. Technol. Res. contributor: fullname: Tokuji – volume: 206 year: 2020 ident: b0565 article-title: Antimicrobial evaluation of neutral and cationic iridium(III) and rhodium(III) aminoquinoline-benzimidazole hybrid complexes publication-title: Eur. J. Med. Chem. contributor: fullname: Smith – year: 2023 ident: b0625 article-title: Exploring the antimalarial and antioxidant efficacy of transition metal(II) chelates of thiosemicarbazone ligands: spectral investigations, molecular docking, DFT, MESP and ADMET publication-title: BioMetals. contributor: fullname: Boora – volume: 987–988 year: 2023 ident: b0445 article-title: Investigation of bioorganometallic artemisinins as antiplasmodials publication-title: J. Organomet. Chem. contributor: fullname: Chellan – volume: 117 start-page: 381 year: 2011 end-page: 392 ident: b0045 article-title: The pathogenesis of Plasmodium falciparum malaria in humans: insights from splenic physiology publication-title: Blood. contributor: fullname: Mercereau-Puijalon – volume: 18 start-page: 1 year: 2020 end-page: 37 ident: b0725 article-title: Recent updates in the development of mettallocenes with antimalarial activity, Facta Univ. - Ser. Physics publication-title: Chem. Technol. contributor: fullname: Radulovic – volume: 159 year: 2024 ident: b0630 article-title: Exploring the antimalarial, antioxidant, anti-inflammatory activities of newly synthesized transition metal(II) complexes bearing thiosemicarbazone ligands: Insights from molecular docking, DFT, MESP and ADMET studies publication-title: Inorg. Chem. Commun. contributor: fullname: Sharma – volume: 2 start-page: 366 year: 2010 ident: b0580 article-title: Cysteine proteases as targets for metal-based drugs publication-title: Metallomics. contributor: fullname: Fricker – volume: 695 start-page: 2225 year: 2010 end-page: 2232 ident: b0595 article-title: Cyclopalladated complexes containing tridentate thiosemicarbazone ligands of biological significance: Synthesis, structure and antimalarial activity publication-title: J. Organomet. Chem. contributor: fullname: Smith – volume: 56 start-page: 1596 year: 2013 end-page: 1613 ident: b0260 article-title: Structural characteristics of chloroquine-bridged ferrocenophane analogues of ferroquine may obviate malaria drug-resistance mechanisms publication-title: J. Med. Chem. contributor: fullname: Orvig – volume: 86 start-page: 113 year: 2014 end-page: 121 ident: b0515 article-title: 1H–1,2,3-triazole tethered mono- and bis-ferrocenylchalcone-β-lactam conjugates: Synthesis and antimalarial evaluation publication-title: Eur. J. Med. Chem. contributor: fullname: Kumar – volume: 29 year: 2023 ident: b0370 article-title: Antimalarial Agents Derived from Metal-Amodiaquine Complexes with Activity in Multiple Stages of the Plasmodium Life Cycle publication-title: Chem. – A Eur. J. contributor: fullname: Moreira – volume: 39 start-page: 1095 year: 1996 end-page: 1099 ident: b0125 article-title: Toward a novel metal-based chemotherapy against tropical diseases. 2. Synthesis and antimalarial activity in vitro and in vivo of new ruthenium− and rhodium−chloroquine complexes publication-title: J. Med. Chem. contributor: fullname: Urbina – volume: 41 start-page: 6443 year: 2012 ident: b0335 article-title: Synthesis and biological activity of cymantrene and cyrhetrene 4-aminoquinoline conjugates against malaria, leishmaniasis, and trypanosomiasis publication-title: Dalt. Trans. contributor: fullname: Nordlander – volume: 723 start-page: 143 year: 2013 end-page: 148 ident: b0700 article-title: Cyrhetrenyl chalcones: Synthesis, characterization and antimalarial evaluation publication-title: J. Organomet. Chem. contributor: fullname: Klahn – volume: 62 start-page: 420 year: 2019 end-page: 444 ident: b0715 article-title: Polypharmacology by Design: A Medicinal Chemist’s Perspective on Multitargeting Compounds publication-title: J. Med. Chem. contributor: fullname: Merk – volume: 383 start-page: 723 year: 2014 end-page: 735 ident: b0050 article-title: Malaria publication-title: Lancet. contributor: fullname: Dondorp – volume: 101 start-page: 534 year: 2015 end-page: 551 ident: b0170 article-title: Ferroquine and its derivatives: New generation of antimalarial agents publication-title: Eur. J. Med. Chem. contributor: fullname: Hun – volume: 4 start-page: 827 year: 2005 end-page: 840 ident: b0395 article-title: Pathogenesis, clinical features, and neurological outcome of cerebral malaria publication-title: Lancet Neurol. contributor: fullname: Newton – volume: 21 start-page: 2643 year: 2020 end-page: 2658 ident: b0540 article-title: The in Vitro antiplasmodial and antiproliferative activity of new ferrocene-based α-aminocresols targeting hemozoin inhibition and DNA interaction publication-title: Chembiochem. contributor: fullname: Khanye – volume: 48 start-page: 1122 year: 2009 end-page: 1131 ident: b0235 article-title: Synthesis, characterization, and in vitro antimalarial and antitumor activity of new ruthenium(II) complexes of chloroquine publication-title: Inorg. Chem. contributor: fullname: Sánchez-Delgado – volume: 5 start-page: e214 year: 2024 ident: b0025 article-title: The 2023 WHO World malaria report publication-title: Lancet Microbe. contributor: fullname: Venkatesan – volume: 26 start-page: 8676 year: 2020 end-page: 8688 ident: b0190 article-title: Enhancing the activity of drugs by conjugation to organometallic fragments publication-title: Chem. – A Eur. J. contributor: fullname: Sadler – volume: 8 start-page: 2739 year: 2000 end-page: 2745 ident: b0420 article-title: Novel ferrocenic artemisinin derivatives: synthesis, in vitro antimalarial activity and affinity of binding with ferroprotoporphyrin IX publication-title: Bioorg. Med. Chem. contributor: fullname: Dive – volume: 172 start-page: 88 year: 2017 end-page: 93 ident: b0490 article-title: Ferrocenyl and organic novobiocin derivatives: Synthesis and their in vitro biological activity publication-title: J. Inorg. Biochem. contributor: fullname: Khanye – volume: 41 start-page: 2764 year: 2012 ident: b0340 article-title: Ruthenium(ii) arene complexes with chelating chloroquine analogue ligands: Synthesis, characterization and in vitro antimalarial activity publication-title: Dalt. Trans. contributor: fullname: Nordlander – volume: 128 start-page: 292 year: 2020 end-page: 303 ident: b0065 article-title: A literature review on traditional herbal medicines for malaria publication-title: South African J. Bot. contributor: fullname: Subramanian – volume: 31 start-page: 5791 year: 2012 end-page: 5799 ident: b0575 article-title: Exploring the versatility of cycloplatinated thiosemicarbazones as antitumor and antiparasitic agents publication-title: Organometallics. contributor: fullname: Smith – volume: 348 start-page: 618 year: 2003 end-page: 629 ident: b0465 article-title: Selective Estrogen-Receptor Modulators — Mechanisms of Action and Application to Clinical Practice publication-title: N. Engl. J. Med. contributor: fullname: Hartmann – volume: 13 start-page: 36035 year: 2023 end-page: 36047 ident: b0675 article-title: Chalcone Mannich base derivatives: synthesis, antimalarial activities against Plasmodium knowlesi, and molecular docking analysis publication-title: RSC Adv. contributor: fullname: Ling – volume: 11 start-page: 849 year: 2013 end-page: 862 ident: b0060 article-title: Antimalarial drug discovery — approaches and progress towards new medicines publication-title: Nat. Rev. Microbiol. contributor: fullname: Winzeler – volume: 273 start-page: 16192 year: 1998 end-page: 16198 ident: b0750 article-title: The Plasmodium falciparum Translationally Controlled Tumor Protein Homolog and Its Reaction with the Antimalarial Drug Artemisinin publication-title: J. Biol. Chem. contributor: fullname: Meshnick – volume: 26 start-page: 1333 year: 2021 ident: b0530 article-title: Coumarin-annulated ferrocenyl 1,3-oxazine derivatives possessing in vitro antimalarial and antitrypanosomal potency publication-title: Molecules. contributor: fullname: Khanye – volume: 26 start-page: 473 year: 2017 end-page: 483 ident: b0550 article-title: Synthesis of an organo-ruthenium aminoquinoline-trioxane hybrid and evaluation of its activity against Plasmodium falciparum and its toxicity toward normal mammalian cells publication-title: Med. Chem. Res. contributor: fullname: Sánchez-Delgado – volume: 696 start-page: 3296 year: 2011 end-page: 3300 ident: b0615 article-title: Ferrocenylthiosemicarbazones conjugated to a poly(propyleneimine) dendrimer scaffold: Synthesis and in vitro antimalarial activity publication-title: J. Organomet. Chem. contributor: fullname: Smith – volume: 41 start-page: 6431 year: 2012 ident: b0285 article-title: 1,2-Disubstituted ferrocenyl carbohydrate chloroquine conjugates as potential antimalarial agents publication-title: Dalt. Trans. contributor: fullname: Orvig – volume: 264 year: 2024 ident: b0095 article-title: Exploring diverse frontiers: Advancements of bioactive 4-aminoquinoline-based molecular hybrids in targeted therapeutics and beyond publication-title: Eur. J. Med. Chem. contributor: fullname: Hassan – volume: 41 start-page: 69 year: 2008 end-page: 77 ident: b0765 article-title: Hybrid molecules with a dual mode of action: dream or reality? publication-title: Acc. Chem. Res. contributor: fullname: Meunier – volume: 28 start-page: 289 year: 2018 end-page: 292 ident: b0425 article-title: Synthesis, in vitro antimalarial activities and cytotoxicities of amino-artemisinin-ferrocene derivatives publication-title: Bioorg. Med. Chem. Lett. contributor: fullname: N’Da – volume: 259 year: 2023 ident: b0090 article-title: Triazole hybrid compounds: A new frontier in malaria treatment publication-title: Eur. J. Med. Chem. contributor: fullname: Hassan – volume: 161 start-page: 11 year: 2019 end-page: 21 ident: b0655 article-title: Structure-activity relationship studies of antiplasmodial cyclometallated ruthenium(II), rhodium(III) and iridium(III) complexes of 2-phenylbenzimidazoles publication-title: Eur. J. Med. Chem. contributor: fullname: Smith – volume: 33 start-page: 4345 year: 2014 end-page: 4348 ident: b0275 article-title: Synthesis and evaluation of a carbosilane congener of ferroquine and its corresponding half-sandwich ruthenium and rhodium complexes for antiplasmodial and β-hematin inhibition activity publication-title: Organometallics. contributor: fullname: Smith – start-page: 73 year: 2019 end-page: 105 ident: b0760 article-title: The hybrid antimalarial approach publication-title: Annu. Reports Med. Chem. contributor: fullname: Singh – volume: 49 start-page: 11543 year: 2020 end-page: 11555 ident: b0560 article-title: Quinoline-triazole half-sandwich iridium(iii) complexes: synthesis, antiplasmodial activity and preliminary transfer hydrogenation studies publication-title: Dalt. Trans. contributor: fullname: Smith – volume: 6 start-page: 81 year: 2007 ident: b0195 article-title: In vitro activity of ferroquine (SSR 97193) against Plasmodium falciparum isolates from the Thai-Burmese border publication-title: Malar. J. contributor: fullname: Nosten – volume: 35 start-page: 126 year: 2013 end-page: 129 ident: b0650 article-title: Organometallic benzimidazoles: Synthesis, characterization and antimalarial activity publication-title: Inorg. Chem. Commun. contributor: fullname: Arancibia – volume: 234 year: 2022 ident: b0405 article-title: Rhenium(I) derivatives of aminoquinoline and imidazolopiperidine-based ligands: Synthesis, in vitro and in silico biological evaluation against Plasmodium falciparum publication-title: J. Inorg. Biochem. contributor: fullname: Zobi – volume: 540 year: 2022 ident: b0665 article-title: Synthesis and study of organometallic PGM complexes containing 2-(2-pyridyl)benzimidazole as antiplasmodial agents publication-title: Inorganica Chim. Acta. contributor: fullname: Chellan – volume: 962 year: 2022 ident: b0660 article-title: Investigating the antiplasmodial activity of substituted cyclopentadienyl rhodium and iridium complexes of 2-(2-pyridyl)benzimidazole publication-title: J. Organomet. Chem. contributor: fullname: Chellan – volume: 97 start-page: 164 year: 2015 end-page: 172 ident: b0435 article-title: New efficient artemisinin derived agents against human leukemia cells, human cytomegalovirus and Plasmodium falciparum: 2nd generation 1,2,4-trioxane-ferrocene hybrids publication-title: Eur. J. Med. Chem. contributor: fullname: Tsogoeva – volume: 191 start-page: 164 year: 2019 end-page: 173 ident: b0555 article-title: Evaluation of PTA-derived ruthenium(II) and iridium(III) quinoline complexes against chloroquine-sensitive and resistant strains of the Plasmodium falciparum malaria parasite publication-title: J. Inorg. Biochem. contributor: fullname: Nordlander – volume: 716 start-page: 216 year: 2012 end-page: 221 ident: b0305 article-title: Synthesis of 2-ferrocenylquinoline derivatives and evaluation of their antimalarial activity publication-title: J. Organomet. Chem. contributor: fullname: De Donno – volume: 13 start-page: 4047 year: 2020 end-page: 4060 ident: b0035 article-title: Antimalarial drug resistance and novel targets for antimalarial drug discovery publication-title: Infect. Drug Resist. contributor: fullname: Atnafie – volume: 56 start-page: 3733 year: 2013 end-page: 3741 ident: b0460 article-title: Pyridine-Substituted Desoxyritonavir Is a More Potent Inhibitor of Cytochrome P450 3A4 than Ritonavir publication-title: J. Med. Chem. contributor: fullname: Poulos – volume: 105 start-page: 985 year: 2011 end-page: 990 ident: b0330 article-title: Synthesis, characterization and antimalarial activity of new chromium arene-quinoline half sandwich complexes publication-title: J. Inorg. Biochem. contributor: fullname: Nordlander – volume: 193 year: 2020 ident: b0670 article-title: Chalcone hybrids as privileged scaffolds in antimalarial drug discovery: A key review publication-title: Eur. J. Med. Chem. contributor: fullname: Rakesh – volume: 8 start-page: e1000402 year: 2011 ident: b0775 article-title: A research agenda for malaria eradication: drugs publication-title: PLoS Med. contributor: fullname: Rabinovich – volume: 61 start-page: 358 year: 2011 end-page: 365 ident: b0250 article-title: Synthesis and in vitro antiplasmodial activityof quinoline-ferrocene esters publication-title: Arzneimittelforschung. contributor: fullname: Lategan – volume: 91 start-page: 653 year: 2019 end-page: 669 ident: b0680 article-title: Perspectives of ferrocenyl chalcones: synthetic scaffolds toward biomedical and materials science applications publication-title: Pure Appl. Chem. contributor: fullname: Durán-Camacho – volume: 16 start-page: 1 year: 2014 end-page: 23 ident: b0015 article-title: Emergency department management of mosquito-borne illness: malaria, dengue, and West Nile virus publication-title: Emerg. Med. Pract. contributor: fullname: King – volume: 10 year: 2019 ident: b0055 article-title: Sticking for a cause: the falciparum malaria parasites cytoadherence paradigm publication-title: Front. Immunol. contributor: fullname: Rénia – volume: 18 start-page: 8085 year: 2010 end-page: 8091 ident: b0325 article-title: Synthesis and antimalarial activities of rhenium bioorganometallics based on the 4-aminoquinoline structure, Bioorganic publication-title: Med. Chem. contributor: fullname: Biot – volume: 215 year: 2021 ident: b0400 article-title: Diversification of quinoline-triazole scaffolds with CORMs: Synthesis, in vitro and in silico biological evaluation against Plasmodium falciparum publication-title: J. Inorg. Biochem. contributor: fullname: Smith – volume: 110 start-page: 981 year: 2015 end-page: 988 ident: b0475 article-title: Antiplasmodial activity of iron(II) and ruthenium(II) organometallic complexes against Plasmodium falciparum blood parasites publication-title: Mem. Inst. Oswaldo Cruz. contributor: fullname: Krettli – volume: 366 start-page: 91 year: 2018 end-page: 108 ident: b0165 article-title: Recent developments in the chemistry of ferrocenyl secondary natural product conjugates publication-title: Coord. Chem. Rev. contributor: fullname: Kowalski – volume: 13 start-page: 703 year: 2007 end-page: 710 ident: b0390 article-title: Heme oxygenase-1 and carbon monoxide suppress the pathogenesis of experimental cerebral malaria publication-title: Nat. Med. contributor: fullname: Mota – volume: 11 year: 2021 ident: b0485 article-title: The Prospective Synergy of Antitubercular Drugs With NAD Biosynthesis Inhibitors publication-title: Front. Microbiol. contributor: fullname: Sorci – volume: 899 year: 2021 ident: b0645 article-title: Benzimidazole based hybrids against complex diseases: A catalogue of the SAR profile publication-title: Eur. J. Pharmacol. contributor: fullname: Silakari – volume: 1 start-page: 0066 year: 2017 ident: b0720 article-title: The medicinal chemistry of ferrocene and its derivatives publication-title: Nat. Rev. Chem. contributor: fullname: Gasser – volume: 45 start-page: 5514 year: 2016 end-page: 5520 ident: b0610 article-title: Cyclopalladated organosilane–tethered thiosemicarbazones: novel strategies for improving antiplasmodial activity publication-title: Dalt. Trans. contributor: fullname: Smith – volume: 22 start-page: 3239 year: 2014 end-page: 3244 ident: b0120 article-title: Synthesis and antimalarial activity of metal complexes of cross-bridged tetraazamacrocyclic ligands, Bioorganic publication-title: Med. Chem. contributor: fullname: Khan – volume: 53 start-page: 3214 year: 2010 end-page: 3226 ident: b0245 article-title: Antimalarial versus cytotoxic properties of dual drugs derived from 4-aminoquinolines and mannich bases: interaction with DNA publication-title: J. Med. Chem. contributor: fullname: Davioud-Charvet – volume: 3 start-page: 5 year: 2010 ident: b0005 article-title: History of discovering the malaria parasites and their vectors publication-title: Parasit. Vectors. contributor: fullname: Cox – volume: 93 start-page: 57 year: 2015 end-page: 68 ident: b0070 article-title: Antimalarial drug resistance: literature review and activities and findings of the ICEMR network publication-title: Am. J. Trop. Med. Hyg. contributor: fullname: Rosenthal – volume: 180 start-page: 121 year: 2019 end-page: 133 ident: b0545 article-title: Bioisosteric ferrocenyl aminoquinoline-benzimidazole hybrids: Antimicrobial evaluation and mechanistic insights publication-title: Eur. J. Med. Chem. contributor: fullname: Smith – volume: 17 year: 2024 ident: b0100 article-title: Structure-based design, and development of amidinyl, amidoximyl and hydroxamic acid based organic molecules as novel antimalarial drug candidates publication-title: Arab. J. Chem. contributor: fullname: Adebiyi – volume: 87 start-page: 801 year: 2014 end-page: 804 ident: b0520 article-title: 1H–1,2,3-triazole tethered isatin-ferrocene conjugates: Synthesis and in vitro antimalarial evaluation publication-title: Eur. J. Med. Chem. contributor: fullname: Kumar – volume: 1085 start-page: 162 year: 2015 end-page: 172 ident: b0705 article-title: Ferrocenyl-cymantrenyl hetero-bimetallic chalcones: Synthesis, structure and biological properties publication-title: J. Mol. Struct. contributor: fullname: Chatterjee – volume: 143 start-page: 1543 year: 2016 end-page: 1556 ident: b0360 article-title: Chloroquine-containing organoruthenium complexes are fast-acting multistage antimalarial agents publication-title: Parasitology. contributor: fullname: Soares – volume: 187 year: 2020 ident: b0300 article-title: Design and synthesis of novel ferrocene-quinoline conjugates and evaluation of their electrochemical and antiplasmodium properties publication-title: Eur. J. Med. Chem. contributor: fullname: D’hooghe – volume: 2020 start-page: 1 year: 2020 end-page: 9 ident: b0150 article-title: Review of atypical organometallic compounds as antimalarial drugs publication-title: J. Chem. contributor: fullname: Miller – volume: 256 year: 2023 ident: b0085 article-title: Recent developments in antimalarial activities of 4-aminoquinoline derivatives publication-title: Eur. J. Med. Chem. contributor: fullname: Hassan – volume: 25 start-page: 568 year: 2016 end-page: 584 ident: b0695 article-title: Synthesis and in vitro biological activities of ferrocenyl–chalcone amides publication-title: Med. Chem. Res. contributor: fullname: N’Da – volume: 18 year: 2023 ident: b0155 article-title: Transition metal complexes as antimalarial agents: A review publication-title: ChemMedChem. contributor: fullname: Banerjee – volume: 21 start-page: 1056 year: 2021 end-page: 1057 ident: b0415 article-title: Has artemisinin resistance emerged in Africa? publication-title: Lancet Infect. Dis. contributor: fullname: Rosenthal – volume: 5 start-page: 32 year: 2019 end-page: 39 ident: b0745 article-title: Artemisinin, the magic drug discovered from traditional chinese medicine publication-title: Engineering. contributor: fullname: Tu – volume: 40 start-page: 3715 year: 1997 end-page: 3718 ident: b0240 article-title: Synthesis and antimalarial activity in vitro and in vivo of a new ferrocene−chloroquine analogue publication-title: J. Med. Chem. contributor: fullname: Lebibi – year: 2024 ident: b0080 article-title: Malaria vaccine efficacy, safety, and community perception in Africa: a scoping review of recent empirical studies publication-title: Infection. contributor: fullname: Sim – volume: 125 start-page: 269 year: 2017 end-page: 277 ident: b0510 article-title: 4-Aminoquinoline-ferrocenyl-chalcone conjugates: Synthesis and anti-plasmodial evaluation publication-title: Eur. J. Med. Chem. contributor: fullname: Kumar – volume: 23 start-page: 1214 year: 2014 end-page: 1224 ident: b0255 article-title: Synthesis, in vitro antiplasmodial and antiproliferative activities of a series of quinoline–ferrocene hybrids publication-title: Med. Chem. Res. contributor: fullname: Smith – volume: 9 start-page: 1815 year: 2000 end-page: 1827 ident: b0735 article-title: Artemisinin drugs: novel antimalarial agents publication-title: Expert Opin. Investig. Drugs. contributor: fullname: Price – start-page: 155 year: 2010 end-page: 193 ident: b0210 article-title: Bioorganometallic chemistry and malaria publication-title: Med. Organomet. Chem. contributor: fullname: Dive – volume: 13 start-page: 2900 year: 2008 end-page: 2907 ident: b0730 article-title: Ferroquine, an Ingenious Antimalarial Drug –Thoughts on the Mechanism of Action publication-title: Molecules. contributor: fullname: Biot – year: 2022 ident: b0640 article-title: Benzimidazole: pharmacological profile publication-title: Benzimidazole contributor: fullname: Gadegoni – start-page: 1 year: 2011 end-page: 47 ident: b0110 article-title: Medicinal inorganic chemistry: state of the art, new trends, and a vision of the future publication-title: Bioinorg. Med. Chem. contributor: fullname: Sadler – volume: 219 year: 2021 ident: b0455 article-title: Bioactive half-sandwich Rh and Ir bipyridyl complexes containing artemisinin publication-title: J. Inorg. Biochem. contributor: fullname: Sadler – volume: 22 start-page: 436 year: 2022 end-page: 472 ident: b0185 article-title: Structural-activity relationship of metallo-aminoquines as next generation antimalarials publication-title: Curr. Top. Med. Chem. contributor: fullname: Joshi – volume: 25 start-page: 24 year: 2018 ident: b0410 article-title: Plasmodium falciparum resistance to artemisinin-based combination therapies: A sword of Damocles in the path toward malaria elimination publication-title: Parasite. contributor: fullname: Benoit-Vical – volume: 3 start-page: 383 year: 2008 end-page: 391 ident: b0215 article-title: Ferrocene conjugates of chloroquine and other antimalarials: the development of ferroquine, a new antimalarial publication-title: ChemMedChem. contributor: fullname: Biot – volume: 75 start-page: 403 year: 2014 end-page: 412 ident: b0525 article-title: Synthesis and study of cytotoxic activity of 1,2,4-trioxane- and egonol-derived hybrid molecules against Plasmodium falciparum and multidrug-resistant human leukemia cells publication-title: Eur. J. Med. Chem. contributor: fullname: Tsogoeva – volume: 424 start-page: 957 year: 2003 end-page: 961 ident: b0755 article-title: Artemisinins target the SERCA of Plasmodium falciparum publication-title: Nature. contributor: fullname: Krishna – volume: 15 start-page: 6510 year: 2007 end-page: 6516 ident: b0220 article-title: Metallocene-based antimalarials: An exploration into the influence of the ferrocenyl moiety on in vitro antimalarial activity in chloroquine-sensitive and chloroquine-resistant strains of Plasmodium falciparum publication-title: Bioorg. Med. Chem. contributor: fullname: Chibale – volume: 31 start-page: 5736 year: 2012 end-page: 5747 ident: b0290 article-title: 1,1′-Disubstituted ferrocenyl carbohydrate chloroquine conjugates as potential antimalarials publication-title: Organometallics. contributor: fullname: Orvig – volume: 51 start-page: 1463 year: 2007 end-page: 1472 ident: b0780 article-title: Trioxaquines are new antimalarial agents active on all erythrocytic forms, including gametocytes publication-title: Antimicrob. Agents Chemother. contributor: fullname: Meunier – volume: 3 start-page: 17050 year: 2017 ident: b0010 article-title: Malaria publication-title: Nat. Rev. Dis. Prim. contributor: fullname: Wells – volume: 44 start-page: 19314 year: 2015 end-page: 19329 ident: b0345 article-title: Antimalarial activity of ruthenium(II) and osmium(II) arene complexes with mono- and bidentate chloroquine analogue ligands publication-title: Dalton Trans. contributor: fullname: Nordlander – volume: 819 start-page: 166 year: 2016 end-page: 172 ident: b0620 article-title: Mono- and polynuclear ferrocenylthiosemicarbazones: Synthesis, characterisation and antimicrobial evaluation publication-title: J. Organomet. Chem. contributor: fullname: Smith – volume: 59 start-page: 12722 year: 2020 end-page: 12732 ident: b0710 article-title: Half-Sandwich Cyclopentadienylruthenium(II) Complexes: A New Antimalarial Chemotype publication-title: Inorg. Chem. contributor: fullname: Moreira – volume: 45 start-page: 19086 year: 2016 end-page: 19095 ident: b0280 article-title: Bioisosteric ferrocenyl-containing quinolines with antiplasmodial and antitrichomonal properties publication-title: Dalt. Trans. contributor: fullname: Smith – volume: 145 start-page: 398 year: 2011 end-page: 409 ident: b0380 article-title: Sickle Hemoglobin Confers Tolerance to Plasmodium Infection publication-title: Cell. contributor: fullname: Soares – volume: 185 year: 2020 ident: b0230 article-title: Current scenario of ferrocene-containing hybrids for antimalarial activity publication-title: Eur. J. Med. Chem. contributor: fullname: Gao – volume: 739 start-page: 15 year: 2013 end-page: 20 ident: b0590 article-title: Heterobimetallic ferrocenylthiosemicarbazone palladium(II) complexes: Synthesis, electrochemistry and antiplasmodial evaluation publication-title: J. Organomet. Chem. contributor: fullname: Smith – volume: 90 start-page: 519 year: 2015 end-page: 525 ident: b0265 article-title: Synthesis and in vitro antiplasmodial activity of ferrocenyl aminoquinoline derivatives publication-title: Eur. J. Med. Chem. contributor: fullname: Pélinski – volume: 47 start-page: 1635 year: 2018 end-page: 1649 ident: b0320 article-title: Isomeric and hybrid ferrocenyl/cyrhetrenyl aldimines: a new family of multifunctional compounds publication-title: Dalt. Trans. contributor: fullname: Messeguer – volume: 25 start-page: 5276 year: 2020 ident: b0175 article-title: Recent advances in the biological investigation of organometallic platinum-group metal (Ir, Ru, Rh, Os, Pd, Pt) complexes as antimalarial agents publication-title: Molecules. contributor: fullname: Smith – volume: 44 start-page: 2456 year: 2015 end-page: 2468 ident: b0605 article-title: Improved antiparasitic activity by incorporation of organosilane entities into half-sandwich ruthenium(ii) and rhodium(iii) thiosemicarbazone complexes publication-title: Dalt. Trans. contributor: fullname: Smith – volume: 2 start-page: 185 year: 2005 end-page: 193 ident: b0200 article-title: Insights into the mechanism of action of ferroquine. Relationship between physicochemical properties and antiplasmodial activity publication-title: Mol. Pharm. contributor: fullname: Egan – year: 2018 ident: b0180 article-title: Targeting Sensitive-Strain and Resistant-Strain Malaria Parasites Through a Metal-Based Approach contributor: fullname: Smith – volume: 52 start-page: 15786 year: 2023 end-page: 15797 ident: b0450 article-title: Investigation of new ferrocenyl-artesunate derivatives as antiparasitics publication-title: Dalt. Trans. contributor: fullname: Chellan – volume: 28 start-page: 3161 year: 2018 end-page: 3163 ident: b0430 article-title: Synthesis, antimalarial activities and cytotoxicities of amino-artemisinin-1,2-disubstituted ferrocene hybrids publication-title: Bioorg. Med. Chem. Lett. contributor: fullname: N’Da – volume: 42 start-page: 4677 year: 2013 ident: b0585 article-title: The synthesis and antiparasitic activity of aryl- and ferrocenyl-derived thiosemicarbazone ruthenium(ii)–arene complexes publication-title: Dalt. Trans. contributor: fullname: Smith – volume: 56 start-page: 1564 year: 2012 end-page: 1570 ident: b0310 article-title: Novel potent metallocenes against liver stage malaria publication-title: Antimicrob. Agents Chemother. contributor: fullname: Gomes – volume: 183 year: 2023 ident: b0105 article-title: Pyrazole and pyrazoline derivatives as antimalarial agents: A key review publication-title: Eur. J. Pharm. Sci. contributor: fullname: Hassan – volume: 4 start-page: 5469 year: 2014 ident: b0770 article-title: Diversification in the synthesis of antimalarial trioxane and tetraoxane analogs publication-title: RSC Adv. contributor: fullname: Awasthi – start-page: 13 year: 2021 end-page: 27 ident: b0040 article-title: Plasmodium species and drug resistance publication-title: Plasmodium Species Drug Resist contributor: fullname: Tseha – volume: 7 start-page: 1617 year: 2016 end-page: 1627 ident: b0355 article-title: Biological assessment of substituted quinoline based heteroleptic organometallic compounds publication-title: Medchemcomm. contributor: fullname: Patel – volume: 6 start-page: 1756 year: 2021 end-page: 1763 ident: b0440 article-title: Hybrid Compounds Containing a Ferrocene Scaffold as Potential Antimalarials publication-title: ChemistrySelect. contributor: fullname: Aderibigbe – volume: 55 start-page: 10387 year: 2012 end-page: 10404 ident: b0535 article-title: Mimicking the intramolecular hydrogen bond: synthesis, biological evaluation, and molecular modeling of benzoxazines and quinazolines as potential antimalarial agents publication-title: J. Med. Chem. contributor: fullname: Butini – volume: 341 start-page: 603 year: 1993 end-page: 608 ident: b0740 article-title: Qinghaosu publication-title: Lancet. contributor: fullname: White – volume: 32 start-page: 141 year: 2013 end-page: 150 ident: b0270 article-title: Synthesis, characterization, and pharmacological evaluation of silicon-containing aminoquinoline organometallic complexes as antiplasmodial, antitumor, and antimycobacterial agents publication-title: Organometallics. contributor: fullname: Smith – volume: 9 start-page: 1548 year: 2017 end-page: 1561 ident: b0315 article-title: Platinum(<scp>ii</scp>)–chloroquine complexes are antimalarial agents against blood and liver stages by impairing mitochondrial function publication-title: Metallomics. contributor: fullname: Soares – volume: 53 start-page: 4103 year: 2010 end-page: 4109 ident: b0505 article-title: Trioxaferroquines as New Hybrid Antimalarial Drugs publication-title: J. Med. Chem. contributor: fullname: Robert – start-page: 13 year: 2023 end-page: 19 ident: b0635 article-title: A review on benzothiazole derivatives and their biological significances publication-title: Asian J. Res. Med. Pharm. Sci. contributor: fullname: Hazra – volume: 45 start-page: 3905 year: 2016 end-page: 3917 ident: b0350 article-title: Pentamethylcyclopentadienyl-rhodium and iridium complexes containing (N^N and N^O) bound chloroquine analogue ligands: synthesis, characterization and antimalarial properties publication-title: Dalt. Trans. contributor: fullname: Nordlander – volume: 24 start-page: 10078 year: 2018 end-page: 10090 ident: b0480 article-title: Organometallic Conjugates of the Drug Sulfadoxine for Combatting Antimicrobial Resistance publication-title: Chem. – A Eur. J. contributor: fullname: Sadler – volume: 8 start-page: 34377 year: 2023 end-page: 34387 ident: b0685 article-title: Synthesis of Novel Heterocyclic Ferrocenyl Chalcones and Their Biological Evaluation publication-title: ACS Omega. contributor: fullname: Montes-González – volume: 48 start-page: 13143 year: 2019 end-page: 13148 ident: b0365 article-title: N, O -Chelating quinoline-based half-sandwich organorhodium and -iridium complexes: synthesis, antiplasmodial activity and preliminary evaluation as transfer hydrogenation catalysts for the reduction of NAD + publication-title: Dalt. Trans. contributor: fullname: Smith – volume: 4 start-page: 1 year: 2016 end-page: 16 ident: b0075 article-title: Artemisinin-resistant plasmodium falciparum malaria publication-title: Microbiol. Spectr. contributor: fullname: Dondorp – volume: 33 start-page: 4345 year: 2014 ident: 10.1016/j.bioorg.2024.107510_b0275 article-title: Synthesis and evaluation of a carbosilane congener of ferroquine and its corresponding half-sandwich ruthenium and rhodium complexes for antiplasmodial and β-hematin inhibition activity publication-title: Organometallics. doi: 10.1021/om500622p contributor: fullname: Li – volume: 716 start-page: 216 year: 2012 ident: 10.1016/j.bioorg.2024.107510_b0305 article-title: Synthesis of 2-ferrocenylquinoline derivatives and evaluation of their antimalarial activity publication-title: J. Organomet. Chem. doi: 10.1016/j.jorganchem.2012.06.025 contributor: fullname: Patti – volume: 8 start-page: 34377 year: 2023 ident: 10.1016/j.bioorg.2024.107510_b0685 article-title: Synthesis of Novel Heterocyclic Ferrocenyl Chalcones and Their Biological Evaluation publication-title: ACS Omega. doi: 10.1021/acsomega.3c01830 contributor: fullname: Alsina-Sánchez – volume: 24 start-page: 3604 year: 2019 ident: 10.1016/j.bioorg.2024.107510_b0160 article-title: Ferrocene-based compounds with antimalaria/anticancer activity publication-title: Molecules. doi: 10.3390/molecules24193604 contributor: fullname: Peter – volume: 31 start-page: 5736 year: 2012 ident: 10.1016/j.bioorg.2024.107510_b0290 article-title: 1,1′-Disubstituted ferrocenyl carbohydrate chloroquine conjugates as potential antimalarials publication-title: Organometallics. doi: 10.1021/om300354x contributor: fullname: Herrmann – volume: 13 start-page: 703 year: 2007 ident: 10.1016/j.bioorg.2024.107510_b0390 article-title: Heme oxygenase-1 and carbon monoxide suppress the pathogenesis of experimental cerebral malaria publication-title: Nat. Med. doi: 10.1038/nm1586 contributor: fullname: Pamplona – volume: 29 year: 2023 ident: 10.1016/j.bioorg.2024.107510_b0370 article-title: Antimalarial Agents Derived from Metal-Amodiaquine Complexes with Activity in Multiple Stages of the Plasmodium Life Cycle publication-title: Chem. – A Eur. J. contributor: fullname: Colina-Vegas – volume: 47 start-page: 1635 year: 2018 ident: 10.1016/j.bioorg.2024.107510_b0320 article-title: Isomeric and hybrid ferrocenyl/cyrhetrenyl aldimines: a new family of multifunctional compounds publication-title: Dalt. Trans. doi: 10.1039/C7DT04142J contributor: fullname: Oyarzo – volume: 41 start-page: 6431 year: 2012 ident: 10.1016/j.bioorg.2024.107510_b0285 article-title: 1,2-Disubstituted ferrocenyl carbohydrate chloroquine conjugates as potential antimalarial agents publication-title: Dalt. Trans. doi: 10.1039/c2dt12050j contributor: fullname: Herrmann – volume: 256 year: 2023 ident: 10.1016/j.bioorg.2024.107510_b0085 article-title: Recent developments in antimalarial activities of 4-aminoquinoline derivatives publication-title: Eur. J. Med. Chem. doi: 10.1016/j.ejmech.2023.115458 contributor: fullname: Ravindar – volume: 185 year: 2020 ident: 10.1016/j.bioorg.2024.107510_b0230 article-title: Current scenario of ferrocene-containing hybrids for antimalarial activity publication-title: Eur. J. Med. Chem. doi: 10.1016/j.ejmech.2019.111791 contributor: fullname: Xiao – volume: 25 start-page: 24 year: 2018 ident: 10.1016/j.bioorg.2024.107510_b0410 article-title: Plasmodium falciparum resistance to artemisinin-based combination therapies: A sword of Damocles in the path toward malaria elimination publication-title: Parasite. doi: 10.1051/parasite/2018021 contributor: fullname: Ouji – volume: 8 start-page: e1000402 year: 2011 ident: 10.1016/j.bioorg.2024.107510_b0775 article-title: A research agenda for malaria eradication: drugs publication-title: PLoS Med. doi: 10.1371/journal.pmed.1000406 contributor: fullname: Alonso – volume: 12 year: 2023 ident: 10.1016/j.bioorg.2024.107510_b0135 article-title: Development of mitochondria targeting AIE-active cyclometalated iridium complexes as potent antimalarial agents publication-title: Adv. Healthc. Mater. doi: 10.1002/adhm.202202411 contributor: fullname: Kumari – volume: 24 start-page: 139 year: 2019 ident: 10.1016/j.bioorg.2024.107510_b0495 article-title: Novobiocin–ferrocene conjugates possessing anticancer and antiplasmodial activity independent of HSP90 inhibition publication-title: J. Biol. Inorg. Chem. doi: 10.1007/s00775-018-1634-9 contributor: fullname: Mbaba – volume: 20 year: 2023 ident: 10.1016/j.bioorg.2024.107510_b0140 article-title: Synthesis, characterization, antimicrobial and antimalarial activities of azines based schiff bases and their Pd(II) complexes publication-title: Chem. Biodivers. doi: 10.1002/cbdv.202300158 contributor: fullname: Meena – volume: 2 start-page: 366 year: 2010 ident: 10.1016/j.bioorg.2024.107510_b0580 article-title: Cysteine proteases as targets for metal-based drugs publication-title: Metallomics. doi: 10.1039/b924677k contributor: fullname: Fricker – volume: 2020 start-page: 1 year: 2020 ident: 10.1016/j.bioorg.2024.107510_b0150 article-title: Review of atypical organometallic compounds as antimalarial drugs publication-title: J. Chem. doi: 10.1155/2020/9414093 contributor: fullname: Kwofie – volume: 42 start-page: 4677 year: 2013 ident: 10.1016/j.bioorg.2024.107510_b0585 article-title: The synthesis and antiparasitic activity of aryl- and ferrocenyl-derived thiosemicarbazone ruthenium(ii)–arene complexes publication-title: Dalt. Trans. doi: 10.1039/c3dt32740j contributor: fullname: Adams – volume: 41 start-page: 2764 year: 2012 ident: 10.1016/j.bioorg.2024.107510_b0340 article-title: Ruthenium(ii) arene complexes with chelating chloroquine analogue ligands: Synthesis, characterization and in vitro antimalarial activity publication-title: Dalt. Trans. doi: 10.1039/c2dt12083f contributor: fullname: Glans – volume: 19 start-page: 113 year: 2013 ident: 10.1016/j.bioorg.2024.107510_b0500 article-title: Oleanolic acid and ursolic acid in commercial dried fruits publication-title: Food Sci. Technol. Res. doi: 10.3136/fstr.19.113 contributor: fullname: Zhang – volume: 51 start-page: 1463 year: 2007 ident: 10.1016/j.bioorg.2024.107510_b0780 article-title: Trioxaquines are new antimalarial agents active on all erythrocytic forms, including gametocytes publication-title: Antimicrob. Agents Chemother. doi: 10.1128/AAC.00967-06 contributor: fullname: Benoit-Vical – volume: 4 start-page: 1 year: 2016 ident: 10.1016/j.bioorg.2024.107510_b0075 article-title: Artemisinin-resistant plasmodium falciparum malaria publication-title: Microbiol. Spectr. doi: 10.1128/microbiolspec.EI10-0013-2016 contributor: fullname: Fairhurst – volume: 819 start-page: 166 year: 2016 ident: 10.1016/j.bioorg.2024.107510_b0620 article-title: Mono- and polynuclear ferrocenylthiosemicarbazones: Synthesis, characterisation and antimicrobial evaluation publication-title: J. Organomet. Chem. doi: 10.1016/j.jorganchem.2016.06.032 contributor: fullname: Baartzes – volume: 31 start-page: 5791 year: 2012 ident: 10.1016/j.bioorg.2024.107510_b0575 article-title: Exploring the versatility of cycloplatinated thiosemicarbazones as antitumor and antiparasitic agents publication-title: Organometallics. doi: 10.1021/om300334z contributor: fullname: Chellan – volume: 20 start-page: 39 year: 2018 ident: 10.1016/j.bioorg.2024.107510_b0385 article-title: A Dual Role of Heme Oxygenase-1 in Cancer Cells publication-title: Int. J. Mol. Sci. doi: 10.3390/ijms20010039 contributor: fullname: Chiang – volume: 31 start-page: 5748 year: 2012 ident: 10.1016/j.bioorg.2024.107510_b0295 article-title: Modular synthesis of 1,2- and 1,1′-disubstituted ferrocenyl carbohydrate chloroquine and mefloquine conjugates as potential antimalarial agents publication-title: Organometallics. doi: 10.1021/om300392q contributor: fullname: Herrmann – volume: 1085 start-page: 162 year: 2015 ident: 10.1016/j.bioorg.2024.107510_b0705 article-title: Ferrocenyl-cymantrenyl hetero-bimetallic chalcones: Synthesis, structure and biological properties publication-title: J. Mol. Struct. doi: 10.1016/j.molstruc.2014.12.070 contributor: fullname: Mishra – volume: 13 start-page: 2900 year: 2008 ident: 10.1016/j.bioorg.2024.107510_b0730 article-title: Ferroquine, an Ingenious Antimalarial Drug –Thoughts on the Mechanism of Action publication-title: Molecules. doi: 10.3390/molecules13112900 contributor: fullname: Dubar – year: 2023 ident: 10.1016/j.bioorg.2024.107510_b0625 article-title: Exploring the antimalarial and antioxidant efficacy of transition metal(II) chelates of thiosemicarbazone ligands: spectral investigations, molecular docking, DFT, MESP and ADMET publication-title: BioMetals. contributor: fullname: Devi – volume: 25 start-page: 568 year: 2016 ident: 10.1016/j.bioorg.2024.107510_b0695 article-title: Synthesis and in vitro biological activities of ferrocenyl–chalcone amides publication-title: Med. Chem. Res. doi: 10.1007/s00044-016-1509-y contributor: fullname: Smit – volume: 39 start-page: 1095 year: 1996 ident: 10.1016/j.bioorg.2024.107510_b0125 article-title: Toward a novel metal-based chemotherapy against tropical diseases. 2. Synthesis and antimalarial activity in vitro and in vivo of new ruthenium− and rhodium−chloroquine complexes publication-title: J. Med. Chem. doi: 10.1021/jm950729w contributor: fullname: Sánchez-Delgado – volume: 8 start-page: 2739 year: 2000 ident: 10.1016/j.bioorg.2024.107510_b0420 article-title: Novel ferrocenic artemisinin derivatives: synthesis, in vitro antimalarial activity and affinity of binding with ferroprotoporphyrin IX publication-title: Bioorg. Med. Chem. doi: 10.1016/S0968-0896(00)00206-6 contributor: fullname: Delhaes – volume: 9 start-page: 1548 year: 2017 ident: 10.1016/j.bioorg.2024.107510_b0315 article-title: Platinum(ii)–chloroquine complexes are antimalarial agents against blood and liver stages by impairing mitochondrial function publication-title: Metallomics. doi: 10.1039/C7MT00196G contributor: fullname: Macedo – volume: 19 start-page: 2055 year: 2011 ident: 10.1016/j.bioorg.2024.107510_b0690 article-title: Ferrocenyl chalcones versus organic chalcones: A comparative study of their nematocidal activity publication-title: Bioorg. Med. Chem. doi: 10.1016/j.bmc.2011.01.048 contributor: fullname: Attar – volume: 383 start-page: 723 year: 2014 ident: 10.1016/j.bioorg.2024.107510_b0050 article-title: Malaria publication-title: Lancet. doi: 10.1016/S0140-6736(13)60024-0 contributor: fullname: White – volume: 41 start-page: 69 year: 2008 ident: 10.1016/j.bioorg.2024.107510_b0765 article-title: Hybrid molecules with a dual mode of action: dream or reality? publication-title: Acc. Chem. Res. doi: 10.1021/ar7000843 contributor: fullname: Meunier – volume: 18 year: 2023 ident: 10.1016/j.bioorg.2024.107510_b0155 article-title: Transition metal complexes as antimalarial agents: A review publication-title: ChemMedChem. doi: 10.1002/cmdc.202300326 contributor: fullname: Mandal – year: 2024 ident: 10.1016/j.bioorg.2024.107510_b0080 article-title: Malaria vaccine efficacy, safety, and community perception in Africa: a scoping review of recent empirical studies publication-title: Infection. doi: 10.1007/s15010-024-02196-y contributor: fullname: Chutiyami – volume: 13 start-page: 4047 year: 2020 ident: 10.1016/j.bioorg.2024.107510_b0035 article-title: Antimalarial drug resistance and novel targets for antimalarial drug discovery publication-title: Infect. Drug Resist. doi: 10.2147/IDR.S279433 contributor: fullname: Shibeshi – volume: 61 start-page: 358 year: 2011 ident: 10.1016/j.bioorg.2024.107510_b0250 article-title: Synthesis and in vitro antiplasmodial activityof quinoline-ferrocene esters publication-title: Arzneimittelforschung. doi: 10.1055/s-0031-1296211 contributor: fullname: Da – volume: 264 year: 2024 ident: 10.1016/j.bioorg.2024.107510_b0095 article-title: Exploring diverse frontiers: Advancements of bioactive 4-aminoquinoline-based molecular hybrids in targeted therapeutics and beyond publication-title: Eur. J. Med. Chem. doi: 10.1016/j.ejmech.2023.116043 contributor: fullname: Ravindar – volume: 90 start-page: 519 year: 2015 ident: 10.1016/j.bioorg.2024.107510_b0265 article-title: Synthesis and in vitro antiplasmodial activity of ferrocenyl aminoquinoline derivatives publication-title: Eur. J. Med. Chem. doi: 10.1016/j.ejmech.2014.11.065 contributor: fullname: Mwande-Maguene – volume: 143 start-page: 1543 year: 2016 ident: 10.1016/j.bioorg.2024.107510_b0360 article-title: Chloroquine-containing organoruthenium complexes are fast-acting multistage antimalarial agents publication-title: Parasitology. doi: 10.1017/S0031182016001153 contributor: fullname: Macedo – volume: 219 year: 2021 ident: 10.1016/j.bioorg.2024.107510_b0455 article-title: Bioactive half-sandwich Rh and Ir bipyridyl complexes containing artemisinin publication-title: J. Inorg. Biochem. doi: 10.1016/j.jinorgbio.2021.111408 contributor: fullname: Chellan – volume: 26 start-page: 473 year: 2017 ident: 10.1016/j.bioorg.2024.107510_b0550 article-title: Synthesis of an organo-ruthenium aminoquinoline-trioxane hybrid and evaluation of its activity against Plasmodium falciparum and its toxicity toward normal mammalian cells publication-title: Med. Chem. Res. doi: 10.1007/s00044-016-1769-6 contributor: fullname: Martínez – volume: 45 start-page: 5514 year: 2016 ident: 10.1016/j.bioorg.2024.107510_b0610 article-title: Cyclopalladated organosilane–tethered thiosemicarbazones: novel strategies for improving antiplasmodial activity publication-title: Dalt. Trans. doi: 10.1039/C5DT04918K contributor: fullname: Adams – volume: 193 year: 2020 ident: 10.1016/j.bioorg.2024.107510_b0670 article-title: Chalcone hybrids as privileged scaffolds in antimalarial drug discovery: A key review publication-title: Eur. J. Med. Chem. doi: 10.1016/j.ejmech.2020.112215 contributor: fullname: Qin – volume: 5 start-page: 32 year: 2019 ident: 10.1016/j.bioorg.2024.107510_b0745 article-title: Artemisinin, the magic drug discovered from traditional chinese medicine publication-title: Engineering. doi: 10.1016/j.eng.2018.11.011 contributor: fullname: Wang – volume: 113 start-page: 3450 year: 2013 ident: 10.1016/j.bioorg.2024.107510_b0030 article-title: Metalloantimalarials publication-title: Chem. Rev. doi: 10.1021/cr3001252 contributor: fullname: Salas – start-page: 1 year: 2011 ident: 10.1016/j.bioorg.2024.107510_b0110 article-title: Medicinal inorganic chemistry: state of the art, new trends, and a vision of the future contributor: fullname: Farrer – volume: 37 start-page: 117 year: 2020 ident: 10.1016/j.bioorg.2024.107510_b0205 article-title: Organometallic compounds in drug discovery: Past, present and future publication-title: Drug Discov. Today Technol. doi: 10.1016/j.ddtec.2019.06.001 contributor: fullname: Ong – volume: 187 year: 2020 ident: 10.1016/j.bioorg.2024.107510_b0300 article-title: Design and synthesis of novel ferrocene-quinoline conjugates and evaluation of their electrochemical and antiplasmodium properties publication-title: Eur. J. Med. Chem. doi: 10.1016/j.ejmech.2019.111963 contributor: fullname: Minić – volume: 206 year: 2020 ident: 10.1016/j.bioorg.2024.107510_b0565 article-title: Antimicrobial evaluation of neutral and cationic iridium(III) and rhodium(III) aminoquinoline-benzimidazole hybrid complexes publication-title: Eur. J. Med. Chem. doi: 10.1016/j.ejmech.2020.112694 contributor: fullname: Baartzes – volume: 424 start-page: 957 year: 2003 ident: 10.1016/j.bioorg.2024.107510_b0755 article-title: Artemisinins target the SERCA of Plasmodium falciparum publication-title: Nature. doi: 10.1038/nature01813 contributor: fullname: Eckstein-Ludwig – volume: 13 start-page: 36035 year: 2023 ident: 10.1016/j.bioorg.2024.107510_b0675 article-title: Chalcone Mannich base derivatives: synthesis, antimalarial activities against Plasmodium knowlesi, and molecular docking analysis publication-title: RSC Adv. doi: 10.1039/D3RA05361J contributor: fullname: Syahri – volume: 1 start-page: 0066 year: 2017 ident: 10.1016/j.bioorg.2024.107510_b0720 article-title: The medicinal chemistry of ferrocene and its derivatives publication-title: Nat. Rev. Chem. doi: 10.1038/s41570-017-0066 contributor: fullname: Patra – volume: 56 start-page: 3733 year: 2013 ident: 10.1016/j.bioorg.2024.107510_b0460 article-title: Pyridine-Substituted Desoxyritonavir Is a More Potent Inhibitor of Cytochrome P450 3A4 than Ritonavir publication-title: J. Med. Chem. doi: 10.1021/jm400288z contributor: fullname: Sevrioukova – volume: 161 start-page: 11 year: 2019 ident: 10.1016/j.bioorg.2024.107510_b0655 article-title: Structure-activity relationship studies of antiplasmodial cyclometallated ruthenium(II), rhodium(III) and iridium(III) complexes of 2-phenylbenzimidazoles publication-title: Eur. J. Med. Chem. doi: 10.1016/j.ejmech.2018.10.019 contributor: fullname: Rylands – volume: 56 start-page: 1596 year: 2013 ident: 10.1016/j.bioorg.2024.107510_b0260 article-title: Structural characteristics of chloroquine-bridged ferrocenophane analogues of ferroquine may obviate malaria drug-resistance mechanisms publication-title: J. Med. Chem. doi: 10.1021/jm301422h contributor: fullname: Salas – volume: 9 start-page: 1815 year: 2000 ident: 10.1016/j.bioorg.2024.107510_b0735 article-title: Artemisinin drugs: novel antimalarial agents publication-title: Expert Opin. Investig. Drugs. doi: 10.1517/13543784.9.8.1815 contributor: fullname: Price – volume: 273 start-page: 16192 year: 1998 ident: 10.1016/j.bioorg.2024.107510_b0750 article-title: The Plasmodium falciparum Translationally Controlled Tumor Protein Homolog and Its Reaction with the Antimalarial Drug Artemisinin publication-title: J. Biol. Chem. doi: 10.1074/jbc.273.26.16192 contributor: fullname: Bhisutthibhan – volume: 3 start-page: 17050 year: 2017 ident: 10.1016/j.bioorg.2024.107510_b0010 article-title: Malaria publication-title: Nat. Rev. Dis. Prim. doi: 10.1038/nrdp.2017.50 contributor: fullname: Phillips – volume: 93 start-page: 57 year: 2015 ident: 10.1016/j.bioorg.2024.107510_b0070 article-title: Antimalarial drug resistance: literature review and activities and findings of the ICEMR network publication-title: Am. J. Trop. Med. Hyg. doi: 10.4269/ajtmh.15-0007 contributor: fullname: Cui – volume: 695 start-page: 2225 year: 2010 ident: 10.1016/j.bioorg.2024.107510_b0595 article-title: Cyclopalladated complexes containing tridentate thiosemicarbazone ligands of biological significance: Synthesis, structure and antimalarial activity publication-title: J. Organomet. Chem. doi: 10.1016/j.jorganchem.2010.06.010 contributor: fullname: Chellan – volume: 22 start-page: 3239 year: 2014 ident: 10.1016/j.bioorg.2024.107510_b0120 article-title: Synthesis and antimalarial activity of metal complexes of cross-bridged tetraazamacrocyclic ligands, Bioorganic publication-title: Med. Chem. contributor: fullname: Hubin – volume: 52 start-page: 15786 year: 2023 ident: 10.1016/j.bioorg.2024.107510_b0450 article-title: Investigation of new ferrocenyl-artesunate derivatives as antiparasitics publication-title: Dalt. Trans. doi: 10.1039/D3DT02254D contributor: fullname: Munnik – volume: 158 year: 2023 ident: 10.1016/j.bioorg.2024.107510_b0145 article-title: Exploring the antimalarial, antioxidant and antimicrobial properties of newly synthesized diorganotin(IV) complexes with ONO-donor hydrazone ligands publication-title: Inorg. Chem. Commun. doi: 10.1016/j.inoche.2023.111473 contributor: fullname: Taxak – volume: 234 year: 2022 ident: 10.1016/j.bioorg.2024.107510_b0405 article-title: Rhenium(I) derivatives of aminoquinoline and imidazolopiperidine-based ligands: Synthesis, in vitro and in silico biological evaluation against Plasmodium falciparum publication-title: J. Inorg. Biochem. doi: 10.1016/j.jinorgbio.2022.111905 contributor: fullname: Sovari – volume: 145 start-page: 398 year: 2011 ident: 10.1016/j.bioorg.2024.107510_b0380 article-title: Sickle Hemoglobin Confers Tolerance to Plasmodium Infection publication-title: Cell. doi: 10.1016/j.cell.2011.03.049 contributor: fullname: Ferreira – volume: 21 start-page: 2643 year: 2020 ident: 10.1016/j.bioorg.2024.107510_b0540 article-title: The in Vitro antiplasmodial and antiproliferative activity of new ferrocene-based α-aminocresols targeting hemozoin inhibition and DNA interaction publication-title: Chembiochem. doi: 10.1002/cbic.202000132 contributor: fullname: Mbaba – year: 2022 ident: 10.1016/j.bioorg.2024.107510_b0640 article-title: Benzimidazole: pharmacological profile contributor: fullname: Thatikayala – volume: 975 year: 2022 ident: 10.1016/j.bioorg.2024.107510_b0570 article-title: Heteroleptic Rh(III) phenylpyridyl complexes based on an aminoquinoline-benzimidazole hybrid scaffold: Antiplasmodial evaluation and mechanistic insights publication-title: J. Organomet. Chem. doi: 10.1016/j.jorganchem.2022.122419 contributor: fullname: Baartzes – volume: 366 start-page: 91 year: 2018 ident: 10.1016/j.bioorg.2024.107510_b0165 article-title: Recent developments in the chemistry of ferrocenyl secondary natural product conjugates publication-title: Coord. Chem. Rev. doi: 10.1016/j.ccr.2018.04.008 contributor: fullname: Kowalski – volume: 11 year: 2021 ident: 10.1016/j.bioorg.2024.107510_b0485 article-title: The Prospective Synergy of Antitubercular Drugs With NAD Biosynthesis Inhibitors publication-title: Front. Microbiol. doi: 10.3389/fmicb.2020.634640 contributor: fullname: Rohde – volume: 987–988 year: 2023 ident: 10.1016/j.bioorg.2024.107510_b0445 article-title: Investigation of bioorganometallic artemisinins as antiplasmodials publication-title: J. Organomet. Chem. contributor: fullname: Albertyn – start-page: 155 year: 2010 ident: 10.1016/j.bioorg.2024.107510_b0210 article-title: Bioorganometallic chemistry and malaria contributor: fullname: Biot – ident: 10.1016/j.bioorg.2024.107510_b0130 – volume: 45 start-page: 3905 year: 2016 ident: 10.1016/j.bioorg.2024.107510_b0350 article-title: Pentamethylcyclopentadienyl-rhodium and iridium complexes containing (N^N and N^O) bound chloroquine analogue ligands: synthesis, characterization and antimalarial properties publication-title: Dalt. Trans. doi: 10.1039/C5DT03739E contributor: fullname: Ekengard – volume: 16 start-page: 1 year: 2014 ident: 10.1016/j.bioorg.2024.107510_b0015 article-title: Emergency department management of mosquito-borne illness: malaria, dengue, and West Nile virus publication-title: Emerg. Med. Pract. contributor: fullname: Caraballo – volume: 22 start-page: 436 year: 2022 ident: 10.1016/j.bioorg.2024.107510_b0185 article-title: Structural-activity relationship of metallo-aminoquines as next generation antimalarials publication-title: Curr. Top. Med. Chem. doi: 10.2174/1568026622666220105103751 contributor: fullname: Abid – volume: 4 start-page: 5469 year: 2014 ident: 10.1016/j.bioorg.2024.107510_b0770 article-title: Diversification in the synthesis of antimalarial trioxane and tetraoxane analogs publication-title: RSC Adv. doi: 10.1039/c3ra42513d contributor: fullname: Yadav – volume: 28 start-page: 289 year: 2018 ident: 10.1016/j.bioorg.2024.107510_b0425 article-title: Synthesis, in vitro antimalarial activities and cytotoxicities of amino-artemisinin-ferrocene derivatives publication-title: Bioorg. Med. Chem. Lett. doi: 10.1016/j.bmcl.2017.12.057 contributor: fullname: de Lange – volume: 962 year: 2022 ident: 10.1016/j.bioorg.2024.107510_b0660 article-title: Investigating the antiplasmodial activity of substituted cyclopentadienyl rhodium and iridium complexes of 2-(2-pyridyl)benzimidazole publication-title: J. Organomet. Chem. doi: 10.1016/j.jorganchem.2022.122273 contributor: fullname: Jordaan – volume: 55 start-page: 10387 year: 2012 ident: 10.1016/j.bioorg.2024.107510_b0535 article-title: Mimicking the intramolecular hydrogen bond: synthesis, biological evaluation, and molecular modeling of benzoxazines and quinazolines as potential antimalarial agents publication-title: J. Med. Chem. doi: 10.1021/jm300831b contributor: fullname: Gemma – volume: 23 start-page: 1214 year: 2014 ident: 10.1016/j.bioorg.2024.107510_b0255 article-title: Synthesis, in vitro antiplasmodial and antiproliferative activities of a series of quinoline–ferrocene hybrids publication-title: Med. Chem. Res. doi: 10.1007/s00044-013-0748-4 contributor: fullname: N’Da – volume: 128 start-page: 292 year: 2020 ident: 10.1016/j.bioorg.2024.107510_b0065 article-title: A literature review on traditional herbal medicines for malaria publication-title: South African J. Bot. doi: 10.1016/j.sajb.2019.11.017 contributor: fullname: Noronha – volume: 125 start-page: 269 year: 2017 ident: 10.1016/j.bioorg.2024.107510_b0510 article-title: 4-Aminoquinoline-ferrocenyl-chalcone conjugates: Synthesis and anti-plasmodial evaluation publication-title: Eur. J. Med. Chem. doi: 10.1016/j.ejmech.2016.09.044 contributor: fullname: Singh – volume: 7 start-page: 1617 year: 2016 ident: 10.1016/j.bioorg.2024.107510_b0355 article-title: Biological assessment of substituted quinoline based heteroleptic organometallic compounds publication-title: Medchemcomm. doi: 10.1039/C6MD00251J contributor: fullname: Mehta – volume: 2 start-page: 185 year: 2005 ident: 10.1016/j.bioorg.2024.107510_b0200 article-title: Insights into the mechanism of action of ferroquine. Relationship between physicochemical properties and antiplasmodial activity publication-title: Mol. Pharm. doi: 10.1021/mp0500061 contributor: fullname: Biot – volume: 91 start-page: 653 year: 2019 ident: 10.1016/j.bioorg.2024.107510_b0680 article-title: Perspectives of ferrocenyl chalcones: synthetic scaffolds toward biomedical and materials science applications publication-title: Pure Appl. Chem. doi: 10.1515/pac-2018-0802 contributor: fullname: Montes-González – volume: 899 year: 2021 ident: 10.1016/j.bioorg.2024.107510_b0645 article-title: Benzimidazole based hybrids against complex diseases: A catalogue of the SAR profile publication-title: Eur. J. Pharmacol. doi: 10.1016/j.ejphar.2021.174027 contributor: fullname: Choudhary – volume: 10 year: 2019 ident: 10.1016/j.bioorg.2024.107510_b0055 article-title: Sticking for a cause: the falciparum malaria parasites cytoadherence paradigm publication-title: Front. Immunol. doi: 10.3389/fimmu.2019.01444 contributor: fullname: Lee – volume: 53 start-page: 3214 year: 2010 ident: 10.1016/j.bioorg.2024.107510_b0245 article-title: Antimalarial versus cytotoxic properties of dual drugs derived from 4-aminoquinolines and mannich bases: interaction with DNA publication-title: J. Med. Chem. doi: 10.1021/jm9018383 contributor: fullname: Wenzel – volume: 44 start-page: 14906 year: 2015 ident: 10.1016/j.bioorg.2024.107510_b0375 article-title: Polyamine quinoline rhodium complexes: synthesis and pharmacological evaluation as antiparasitic agents against Plasmodium falciparum and Trichomonas vaginalis publication-title: Dalt. Trans. doi: 10.1039/C5DT02378E contributor: fullname: Stringer – volume: 44 start-page: 19314 year: 2015 ident: 10.1016/j.bioorg.2024.107510_b0345 article-title: Antimalarial activity of ruthenium(II) and osmium(II) arene complexes with mono- and bidentate chloroquine analogue ligands publication-title: Dalton Trans. doi: 10.1039/C5DT02410B contributor: fullname: Ekengard – volume: 117 start-page: 381 year: 2011 ident: 10.1016/j.bioorg.2024.107510_b0045 article-title: The pathogenesis of Plasmodium falciparum malaria in humans: insights from splenic physiology publication-title: Blood. doi: 10.1182/blood-2010-04-202911 contributor: fullname: Buffet – volume: 87 start-page: 801 year: 2014 ident: 10.1016/j.bioorg.2024.107510_b0520 article-title: 1H–1,2,3-triazole tethered isatin-ferrocene conjugates: Synthesis and in vitro antimalarial evaluation publication-title: Eur. J. Med. Chem. doi: 10.1016/j.ejmech.2014.10.024 contributor: fullname: Kumar – volume: 341 start-page: 603 year: 1993 ident: 10.1016/j.bioorg.2024.107510_b0740 article-title: Qinghaosu publication-title: Lancet. doi: 10.1016/0140-6736(93)90362-K contributor: fullname: Hien – volume: 2008 start-page: 1 year: 2008 ident: 10.1016/j.bioorg.2024.107510_b0225 article-title: Metallocene antimalarials: the continuing quest publication-title: Met. Based. Drugs. doi: 10.1155/2008/495123 contributor: fullname: Blackie – volume: 172 start-page: 88 year: 2017 ident: 10.1016/j.bioorg.2024.107510_b0490 article-title: Ferrocenyl and organic novobiocin derivatives: Synthesis and their in vitro biological activity publication-title: J. Inorg. Biochem. doi: 10.1016/j.jinorgbio.2017.04.014 contributor: fullname: Mbaba – volume: 159 year: 2024 ident: 10.1016/j.bioorg.2024.107510_b0630 article-title: Exploring the antimalarial, antioxidant, anti-inflammatory activities of newly synthesized transition metal(II) complexes bearing thiosemicarbazone ligands: Insights from molecular docking, DFT, MESP and ADMET studies publication-title: Inorg. Chem. Commun. doi: 10.1016/j.inoche.2023.111674 contributor: fullname: Kumar – volume: 59 start-page: 12722 year: 2020 ident: 10.1016/j.bioorg.2024.107510_b0710 article-title: Half-Sandwich Cyclopentadienylruthenium(II) Complexes: A New Antimalarial Chemotype publication-title: Inorg. Chem. doi: 10.1021/acs.inorgchem.0c01795 contributor: fullname: Milheiro – start-page: 13 year: 2021 ident: 10.1016/j.bioorg.2024.107510_b0040 article-title: Plasmodium species and drug resistance contributor: fullname: Tseha – year: 2018 ident: 10.1016/j.bioorg.2024.107510_b0180 contributor: fullname: Baartzes – volume: 24 start-page: 10078 year: 2018 ident: 10.1016/j.bioorg.2024.107510_b0480 article-title: Organometallic Conjugates of the Drug Sulfadoxine for Combatting Antimicrobial Resistance publication-title: Chem. – A Eur. J. doi: 10.1002/chem.201801090 contributor: fullname: Chellan – volume: 56 start-page: 1564 year: 2012 ident: 10.1016/j.bioorg.2024.107510_b0310 article-title: Novel potent metallocenes against liver stage malaria publication-title: Antimicrob. Agents Chemother. doi: 10.1128/AAC.05345-11 contributor: fullname: Matos – volume: 11 start-page: 849 year: 2013 ident: 10.1016/j.bioorg.2024.107510_b0060 article-title: Antimalarial drug discovery — approaches and progress towards new medicines publication-title: Nat. Rev. Microbiol. doi: 10.1038/nrmicro3138 contributor: fullname: Flannery – volume: 25 start-page: 5276 year: 2020 ident: 10.1016/j.bioorg.2024.107510_b0175 article-title: Recent advances in the biological investigation of organometallic platinum-group metal (Ir, Ru, Rh, Os, Pd, Pt) complexes as antimalarial agents publication-title: Molecules. doi: 10.3390/molecules25225276 contributor: fullname: Mbaba – volume: 21 start-page: 1056 year: 2021 ident: 10.1016/j.bioorg.2024.107510_b0415 article-title: Has artemisinin resistance emerged in Africa? publication-title: Lancet Infect. Dis. doi: 10.1016/S1473-3099(21)00168-7 contributor: fullname: Rosenthal – volume: 49 start-page: 11543 year: 2020 ident: 10.1016/j.bioorg.2024.107510_b0560 article-title: Quinoline-triazole half-sandwich iridium(iii) complexes: synthesis, antiplasmodial activity and preliminary transfer hydrogenation studies publication-title: Dalt. Trans. doi: 10.1039/D0DT01935F contributor: fullname: Melis – volume: 97 start-page: 164 year: 2015 ident: 10.1016/j.bioorg.2024.107510_b0435 article-title: New efficient artemisinin derived agents against human leukemia cells, human cytomegalovirus and Plasmodium falciparum: 2nd generation 1,2,4-trioxane-ferrocene hybrids publication-title: Eur. J. Med. Chem. doi: 10.1016/j.ejmech.2015.04.053 contributor: fullname: Reiter – volume: 5 start-page: e214 year: 2024 ident: 10.1016/j.bioorg.2024.107510_b0025 article-title: The 2023 WHO World malaria report publication-title: Lancet Microbe. doi: 10.1016/S2666-5247(24)00016-8 contributor: fullname: Venkatesan – volume: 15 start-page: 6510 year: 2007 ident: 10.1016/j.bioorg.2024.107510_b0220 article-title: Metallocene-based antimalarials: An exploration into the influence of the ferrocenyl moiety on in vitro antimalarial activity in chloroquine-sensitive and chloroquine-resistant strains of Plasmodium falciparum publication-title: Bioorg. Med. Chem. doi: 10.1016/j.bmc.2007.07.012 contributor: fullname: Blackie – volume: 17 year: 2024 ident: 10.1016/j.bioorg.2024.107510_b0100 article-title: Structure-based design, and development of amidinyl, amidoximyl and hydroxamic acid based organic molecules as novel antimalarial drug candidates publication-title: Arab. J. Chem. doi: 10.1016/j.arabjc.2023.105573 contributor: fullname: Adebayo – volume: 86 start-page: 113 year: 2014 ident: 10.1016/j.bioorg.2024.107510_b0515 article-title: 1H–1,2,3-triazole tethered mono- and bis-ferrocenylchalcone-β-lactam conjugates: Synthesis and antimalarial evaluation publication-title: Eur. J. Med. Chem. doi: 10.1016/j.ejmech.2014.08.053 contributor: fullname: Kumar – volume: 35 start-page: 126 year: 2013 ident: 10.1016/j.bioorg.2024.107510_b0650 article-title: Organometallic benzimidazoles: Synthesis, characterization and antimalarial activity publication-title: Inorg. Chem. Commun. doi: 10.1016/j.inoche.2013.06.019 contributor: fullname: Toro – volume: 45 start-page: 19086 year: 2016 ident: 10.1016/j.bioorg.2024.107510_b0280 article-title: Bioisosteric ferrocenyl-containing quinolines with antiplasmodial and antitrichomonal properties publication-title: Dalt. Trans. doi: 10.1039/C6DT03175G contributor: fullname: Adams – volume: 75 start-page: 403 year: 2014 ident: 10.1016/j.bioorg.2024.107510_b0525 article-title: Synthesis and study of cytotoxic activity of 1,2,4-trioxane- and egonol-derived hybrid molecules against Plasmodium falciparum and multidrug-resistant human leukemia cells publication-title: Eur. J. Med. Chem. doi: 10.1016/j.ejmech.2014.01.043 contributor: fullname: Reiter – volume: 26 start-page: 1333 year: 2021 ident: 10.1016/j.bioorg.2024.107510_b0530 article-title: Coumarin-annulated ferrocenyl 1,3-oxazine derivatives possessing in vitro antimalarial and antitrypanosomal potency publication-title: Molecules. doi: 10.3390/molecules26051333 contributor: fullname: Mbaba – volume: 215 year: 2021 ident: 10.1016/j.bioorg.2024.107510_b0400 article-title: Diversification of quinoline-triazole scaffolds with CORMs: Synthesis, in vitro and in silico biological evaluation against Plasmodium falciparum publication-title: J. Inorg. Biochem. doi: 10.1016/j.jinorgbio.2020.111328 contributor: fullname: Ishmail – volume: 41 start-page: 6443 year: 2012 ident: 10.1016/j.bioorg.2024.107510_b0335 article-title: Synthesis and biological activity of cymantrene and cyrhetrene 4-aminoquinoline conjugates against malaria, leishmaniasis, and trypanosomiasis publication-title: Dalt. Trans. doi: 10.1039/c2dt30077j contributor: fullname: Glans – volume: 4 start-page: 827 year: 2005 ident: 10.1016/j.bioorg.2024.107510_b0395 article-title: Pathogenesis, clinical features, and neurological outcome of cerebral malaria publication-title: Lancet Neurol. doi: 10.1016/S1474-4422(05)70247-7 contributor: fullname: Idro – start-page: 73 year: 2019 ident: 10.1016/j.bioorg.2024.107510_b0760 article-title: The hybrid antimalarial approach doi: 10.1016/bs.armc.2019.05.002 contributor: fullname: Gupta – volume: 32 start-page: 141 year: 2013 ident: 10.1016/j.bioorg.2024.107510_b0270 article-title: Synthesis, characterization, and pharmacological evaluation of silicon-containing aminoquinoline organometallic complexes as antiplasmodial, antitumor, and antimycobacterial agents publication-title: Organometallics. doi: 10.1021/om300945c contributor: fullname: Li – volume: 53 start-page: 4103 year: 2010 ident: 10.1016/j.bioorg.2024.107510_b0505 article-title: Trioxaferroquines as New Hybrid Antimalarial Drugs publication-title: J. Med. Chem. doi: 10.1021/jm100117e contributor: fullname: Bellot – volume: 3 start-page: 5 year: 2010 ident: 10.1016/j.bioorg.2024.107510_b0005 article-title: History of discovering the malaria parasites and their vectors publication-title: Parasit. Vectors. doi: 10.1186/1756-3305-3-5 contributor: fullname: Cox – volume: 696 start-page: 3296 year: 2011 ident: 10.1016/j.bioorg.2024.107510_b0615 article-title: Ferrocenylthiosemicarbazones conjugated to a poly(propyleneimine) dendrimer scaffold: Synthesis and in vitro antimalarial activity publication-title: J. Organomet. Chem. doi: 10.1016/j.jorganchem.2011.07.028 contributor: fullname: Khanye – volume: 44 start-page: 2456 year: 2015 ident: 10.1016/j.bioorg.2024.107510_b0605 article-title: Improved antiparasitic activity by incorporation of organosilane entities into half-sandwich ruthenium(ii) and rhodium(iii) thiosemicarbazone complexes publication-title: Dalt. Trans. doi: 10.1039/C4DT03234A contributor: fullname: Adams – volume: 48 start-page: 1122 year: 2009 ident: 10.1016/j.bioorg.2024.107510_b0235 article-title: Synthesis, characterization, and in vitro antimalarial and antitumor activity of new ruthenium(II) complexes of chloroquine publication-title: Inorg. Chem. doi: 10.1021/ic802220w contributor: fullname: Rajapakse – volume: 348 start-page: 618 year: 2003 ident: 10.1016/j.bioorg.2024.107510_b0465 article-title: Selective Estrogen-Receptor Modulators — Mechanisms of Action and Application to Clinical Practice publication-title: N. Engl. J. Med. doi: 10.1056/NEJMra022219 contributor: fullname: Riggs – volume: 6 start-page: 1756 year: 2021 ident: 10.1016/j.bioorg.2024.107510_b0440 article-title: Hybrid Compounds Containing a Ferrocene Scaffold as Potential Antimalarials publication-title: ChemistrySelect. doi: 10.1002/slct.202004710 contributor: fullname: Peter – volume: 28 start-page: 3161 year: 2018 ident: 10.1016/j.bioorg.2024.107510_b0430 article-title: Synthesis, antimalarial activities and cytotoxicities of amino-artemisinin-1,2-disubstituted ferrocene hybrids publication-title: Bioorg. Med. Chem. Lett. doi: 10.1016/j.bmcl.2018.08.037 contributor: fullname: de Lange – volume: 259 year: 2023 ident: 10.1016/j.bioorg.2024.107510_b0090 article-title: Triazole hybrid compounds: A new frontier in malaria treatment publication-title: Eur. J. Med. Chem. doi: 10.1016/j.ejmech.2023.115694 contributor: fullname: Ravindar – volume: 3 start-page: 383 year: 2008 ident: 10.1016/j.bioorg.2024.107510_b0215 article-title: Ferrocene conjugates of chloroquine and other antimalarials: the development of ferroquine, a new antimalarial publication-title: ChemMedChem. doi: 10.1002/cmdc.200700127 contributor: fullname: Dive – volume: 723 start-page: 143 year: 2013 ident: 10.1016/j.bioorg.2024.107510_b0700 article-title: Cyrhetrenyl chalcones: Synthesis, characterization and antimalarial evaluation publication-title: J. Organomet. Chem. doi: 10.1016/j.jorganchem.2012.08.024 contributor: fullname: Arancibia – volume: 62 start-page: 420 year: 2019 ident: 10.1016/j.bioorg.2024.107510_b0715 article-title: Polypharmacology by Design: A Medicinal Chemist’s Perspective on Multitargeting Compounds publication-title: J. Med. Chem. doi: 10.1021/acs.jmedchem.8b00760 contributor: fullname: Proschak – volume: 101 start-page: 534 year: 2015 ident: 10.1016/j.bioorg.2024.107510_b0170 article-title: Ferroquine and its derivatives: New generation of antimalarial agents publication-title: Eur. J. Med. Chem. doi: 10.1016/j.ejmech.2015.07.009 contributor: fullname: Wani – volume: 105 start-page: 985 year: 2011 ident: 10.1016/j.bioorg.2024.107510_b0330 article-title: Synthesis, characterization and antimalarial activity of new chromium arene-quinoline half sandwich complexes publication-title: J. Inorg. Biochem. doi: 10.1016/j.jinorgbio.2011.03.019 contributor: fullname: Glans – volume: 736 start-page: 19 year: 2013 ident: 10.1016/j.bioorg.2024.107510_b0600 article-title: Synthesis, characterization and antiplasmodial evaluation of cyclopalladated thiosemicarbazone complexes publication-title: J. Organomet. Chem. doi: 10.1016/j.jorganchem.2013.02.024 contributor: fullname: Adams – volume: 48 start-page: 13143 year: 2019 ident: 10.1016/j.bioorg.2024.107510_b0365 article-title: N, O -Chelating quinoline-based half-sandwich organorhodium and -iridium complexes: synthesis, antiplasmodial activity and preliminary evaluation as transfer hydrogenation catalysts for the reduction of NAD + publication-title: Dalt. Trans. doi: 10.1039/C9DT02030F contributor: fullname: Stringer – volume: 180 start-page: 121 year: 2019 ident: 10.1016/j.bioorg.2024.107510_b0545 article-title: Bioisosteric ferrocenyl aminoquinoline-benzimidazole hybrids: Antimicrobial evaluation and mechanistic insights publication-title: Eur. J. Med. Chem. doi: 10.1016/j.ejmech.2019.06.069 contributor: fullname: Baartzes – ident: 10.1016/j.bioorg.2024.107510_b0470 doi: 10.1016/B978-008055232-3.62712-6 – volume: 18 start-page: 1 year: 2020 ident: 10.1016/j.bioorg.2024.107510_b0725 article-title: Recent updates in the development of mettallocenes with antimalarial activity, Facta Univ. - Ser. Physics publication-title: Chem. Technol. contributor: fullname: Aksic – volume: 183 year: 2023 ident: 10.1016/j.bioorg.2024.107510_b0105 article-title: Pyrazole and pyrazoline derivatives as antimalarial agents: A key review publication-title: Eur. J. Pharm. Sci. doi: 10.1016/j.ejps.2022.106365 contributor: fullname: Ravindar – volume: 6 start-page: 81 year: 2007 ident: 10.1016/j.bioorg.2024.107510_b0195 article-title: In vitro activity of ferroquine (SSR 97193) against Plasmodium falciparum isolates from the Thai-Burmese border publication-title: Malar. J. doi: 10.1186/1475-2875-6-81 contributor: fullname: Barends – volume: 540 year: 2022 ident: 10.1016/j.bioorg.2024.107510_b0665 article-title: Synthesis and study of organometallic PGM complexes containing 2-(2-pyridyl)benzimidazole as antiplasmodial agents publication-title: Inorganica Chim. Acta. doi: 10.1016/j.ica.2022.121039 contributor: fullname: Munnik – start-page: 49 year: 2011 ident: 10.1016/j.bioorg.2024.107510_b0115 article-title: Targeting strategies for metal-based therapeutics contributor: fullname: Norman – volume: 40 start-page: 3715 year: 1997 ident: 10.1016/j.bioorg.2024.107510_b0240 article-title: Synthesis and antimalarial activity in vitro and in vivo of a new ferrocene−chloroquine analogue publication-title: J. Med. Chem. doi: 10.1021/jm970401y contributor: fullname: Biot – volume: 18 start-page: 8085 year: 2010 ident: 10.1016/j.bioorg.2024.107510_b0325 article-title: Synthesis and antimalarial activities of rhenium bioorganometallics based on the 4-aminoquinoline structure, Bioorganic publication-title: Med. Chem. contributor: fullname: Arancibia – volume: 110 start-page: 981 year: 2015 ident: 10.1016/j.bioorg.2024.107510_b0475 article-title: Antiplasmodial activity of iron(II) and ruthenium(II) organometallic complexes against Plasmodium falciparum blood parasites publication-title: Mem. Inst. Oswaldo Cruz. doi: 10.1590/0074-02760150163 contributor: fullname: de Souza – start-page: 13 year: 2023 ident: 10.1016/j.bioorg.2024.107510_b0635 article-title: A review on benzothiazole derivatives and their biological significances publication-title: Asian J. Res. Med. Pharm. Sci. doi: 10.9734/ajrimps/2023/v12i1206 contributor: fullname: Mahapatra – volume: 191 start-page: 164 year: 2019 ident: 10.1016/j.bioorg.2024.107510_b0555 article-title: Evaluation of PTA-derived ruthenium(II) and iridium(III) quinoline complexes against chloroquine-sensitive and resistant strains of the Plasmodium falciparum malaria parasite publication-title: J. Inorg. Biochem. doi: 10.1016/j.jinorgbio.2018.11.018 contributor: fullname: Stringer – ident: 10.1016/j.bioorg.2024.107510_b0020 – volume: 739 start-page: 15 year: 2013 ident: 10.1016/j.bioorg.2024.107510_b0590 article-title: Heterobimetallic ferrocenylthiosemicarbazone palladium(II) complexes: Synthesis, electrochemistry and antiplasmodial evaluation publication-title: J. Organomet. Chem. doi: 10.1016/j.jorganchem.2013.04.017 contributor: fullname: Adams – volume: 26 start-page: 8676 year: 2020 ident: 10.1016/j.bioorg.2024.107510_b0190 article-title: Enhancing the activity of drugs by conjugation to organometallic fragments publication-title: Chem. – A Eur. J. doi: 10.1002/chem.201904699 contributor: fullname: Chellan |
SSID | ssj0011476 |
Score | 2.4093826 |
SecondaryResourceType | review_article |
Snippet | [Display omitted]
In the search for novel ligands with efficacy against various diseases, particularly parasitic diseases, molecular hybridization of... In the search for novel ligands with efficacy against various diseases, particularly parasitic diseases, molecular hybridization of organometallic units into... |
SourceID | proquest crossref pubmed elsevier |
SourceType | Aggregation Database Index Database Publisher |
StartPage | 107510 |
SubjectTerms | Animals Antimalarial Antimalarials - chemical synthesis Antimalarials - chemistry Antimalarials - pharmacology Conjugation Humans Malaria - drug therapy Molecular hybridization Molecular Structure Organometallic Organometallic Compounds - chemical synthesis Organometallic Compounds - chemistry Organometallic Compounds - pharmacology Parasitic Sensitivity Tests Plasmodium falciparum - drug effects Structure-Activity Relationship Transition metal |
Title | Exploring antimalarial potential: Conjugating organometallic moieties with organic fragments for enhanced efficacy |
URI | https://dx.doi.org/10.1016/j.bioorg.2024.107510 https://www.ncbi.nlm.nih.gov/pubmed/38833991 https://www.proquest.com/docview/3064921457/abstract/ |
Volume | 149 |
hasFullText | 1 |
inHoldings | 1 |
isFullTextHit | |
isPrint | |
link | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwnV3da9swED_a9GF7KWu7j6xt0GDsTasTKba8t2Ba0n2UMVbom5AUqXNp7JAmD33Z39472Q4MVgp9tGxjc3fc_U763R3AR2VCikDCczU0jks_MxzjfMadMJiN2CCMo33IHxfp9FJ-vRpfbUHR1cIQrbL1_Y1Pj966XTlppXmyKEuq8ZXjUZIqYkFSGNqGHQxHUvZgZ3L-bXqxOUwYyjhjjp7n9EJXQRdpXras6-U1JoojiUvZmEpp_x-hHkOgMRKdvYLdFkKySfOXe7Dlq304mFSYPs_v2ScWSZ1xt3wfXhTdQLcDWG74dgzFWc4NJrVofWxRr4gyZG6_sKKubtbUcwOfifOe6rlHdH5bOjavS0_NVxnt3DY3cTUszXUskmMIfpmv_kRCAfPUmMK4-9dweXb6u5jyduQCdyi7FUc5ytQmIqg8DSK30qBHsz5RQSkZqHBeCRR2ZsUsGQXp0AQQQVljMpnOjEvFG-hVdeXfATMmJGPnlLepl5mzuctFYvNEGoyaQz_rA-_ErBdNZw3dUc5udKMWTWrRjVr6kHW60P9YiEbn_8SbHzrVaRQ5nYiYytfrO03pV0692rM-vG10uvkXQWOYET2_f_Z3D-ElXTV0wSPorZZrf4wQZmUHsP3573CAhlr8-v5z0BrsAxyo890 |
link.rule.ids | 315,786,790,4521,24144,27955,27956,45618,45712 |
linkProvider | Elsevier |
linkToHtml | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwnV1Nb9QwEB2VcigXRD-ABVqMhHpzm669icOtWlFtoe2plXqzxl67pOomq2X30Au_nRknWakSCImr7SjRzGjmjfNmBuCzwZgTkAjSnKCXOkxRUpwvpFdI2YiLCj3fQ15e5ZMb_e12dLsB474WhmmVne9vfXry1t3KcSfN43lVcY2vHg2z3DALksPQM3jOaIB5XUe_1jwPwvtpwhyflny8r59LJC9XNc3ijtLEoaalYsSFtH-OT3_DnykOnb2Clx2AFKftN27DRqh3YPe0puR59igORaJ0prvyHdga9-PcdmGxZtsJEmY1Q0ppyfbEvFkyYQgfvohxU9-vuOMGnUnTnppZIGz-UHkxa6rArVcF39u2m7QaF3iXSuQEQV8R6h-JTiACt6VA_7gHN2dfr8cT2Q1ckJ4C-VKSFHXuMhVNmUdVOo3kz1zITDRGRy6bN4pEXTg1zYZRezIAwk8OsdD5FH2uXsNm3dThLQjEmI28N8HlQRfelb5UmSszjRQzT8J0ALIXs523fTVsTzi7t61aLKvFtmoZQNHrwj6xD0uu_x9PfupVZ0nk_D8E69CsflpOvkru1F4M4E2r0_W3KB7CTNj53X-_9yNsTa4vL-zF-dX39_CCd1ri4AfYXC5WYZ_AzNIdJGP9Da6a8x0 |
openUrl | ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=Exploring+antimalarial+potential%3A+Conjugating+organometallic+moieties+with+organic+fragments+for+enhanced+efficacy&rft.jtitle=Bioorganic+chemistry&rft.au=Aqilah+Zahirah+Norazmi%2C+Nur&rft.au=Hafizah+Mukhtar%2C+Nur&rft.au=Ravindar%2C+Lekkala&rft.au=Suhaily+Saaidin%2C+Aimi&rft.date=2024-08-01&rft.issn=0045-2068&rft.spage=107510&rft_id=info:doi/10.1016%2Fj.bioorg.2024.107510&rft.externalDBID=n%2Fa&rft.externalDocID=10_1016_j_bioorg_2024_107510 |
thumbnail_l | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=0045-2068&client=summon |
thumbnail_m | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=0045-2068&client=summon |
thumbnail_s | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=0045-2068&client=summon |