Effects of glyprolines on stress-induced behavioral disorders in rats

• Published in: Neuroscience and behavioral physiology Vol. 36; no. 4; pp. 409 - 413
• Main Authors: Badmaeva, S E, Kopylova, G N, Abushinova, N N, Samonina, G E, Umarova, B A
• Format: Journal Article
• Language: English
• Published: United States Springer Nature B.V 01.05.2006
• Subjects: Animals; Behavior, Animal - drug effects; Behavioral Symptoms - drug therapy; Behavioral Symptoms - etiology; Dipeptides - chemistry; Dipeptides - therapeutic use; Exploratory Behavior - drug effects; Male; Maze Learning - drug effects; Neuroprotective Agents - therapeutic use; Rats; Stress, Physiological - complications
• ISSN: 0097-0549; 1573-899X
• DOI: 10.1007/s11055-006-0032-x

We report here studies on the antistress protective actions of three peptides of the glyproline family: Pro-Gly-Pro, Pro-Gly, and Gly-Pro. Stress (10 min forced swimming) evoked typical changes in the behavioral activity of rats in the elevated cross maze and hole board tests, providing evidence of a significant increase in anxiety and a decrease in the level of orientational-investigative activity. Prior (15 min before stress) i.p. administration of Pro-Gly-Pro and Gly-Pro at a dose of 3.7 microM/kg significantly decreased the stress-induced behavioral abnormalities. This demonstrates the possibility that peptides Pro-Gly-Pro and Gly-Pro may affect CNS structures involved in forming the body's responses to stress-inducing factors. Peptide Pro-Gly, at an equimolar dose, had no marked protective effect and only slightly decreased the stress-induced abnormalities in the behavior of rats.