Immunoregulatory effects of L-arginine and therapeutical implications

Arginine, initially classified as a non-essential amino acid, participates to multiple biological processes including release of several hormones, collagen synthesis during wound healing, antitumor and antibacterial activities and non-specific immunity. Nitric oxide synthase and arginase competes fo...

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Bibliographic Details
Published inCurrent drug targets. Immune, endocrine and metabolic disorders Vol. 1; no. 1; p. 67
Main Authors Potenza, M A, Nacci, C, Mitolo-Chieppa, D
Format Journal Article
LanguageEnglish
Published United Arab Emirates 01.05.2001
Subjects
Animals
Arginine - pharmacology
Arginine - physiology
Humans
Immune System - drug effects
Immune System - physiology
Immunity, Cellular - drug effects
Immunity, Cellular - physiology
Macrophages - drug effects
Macrophages - immunology
Phagocytosis - drug effects
Phagocytosis - physiology
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Summary:Arginine, initially classified as a non-essential amino acid, participates to multiple biological processes including release of several hormones, collagen synthesis during wound healing, antitumor and antibacterial activities and non-specific immunity. Nitric oxide synthase and arginase competes for L-arginine as a substrate and this event appears to play a key role in the regulation of the inflammatory process. In this framework recent studies have identified complex patterns of interactions among these enzymes. This review will emphasizes some effects of L-arginine on immune cell functions, including triggering of L-arginine-nitric oxide and arginase pathways, its biological properties and therapeutical applications.
ISSN:1568-0088
DOI:10.2174/1568008013341811