Review: Sporadic Parkinson's disease: development and distribution of α-synuclein pathology

• Published in: Neuropathology and applied neurobiology Vol. 42; no. 1; pp. 33 - 50
• Main Authors: Del Tredici, K., Braak, H.
• Format: Journal Article
• Language: English
• Published: England Blackwell Publishing Ltd 01.02.2016
• Subjects: alpha-Synuclein - metabolism; Animals; autophagy; central nervous system; chaperones; Disease Progression; dorsal motor nucleus of the vagal nerve; enteric nervous system; Enteric Nervous System - pathology; Humans; Lewy pathology; Parkinson Disease - pathology; Parkinson's disease; peripheral nervous system; protein aggregation/misfolding; α-synuclein; Parkinson's disease; autophagy; protein aggregation/misfolding; Lewy pathology; enteric nervous system; peripheral nervous system; chaperones; dorsal motor nucleus of the vagal nerve; α-synuclein; central nervous system

The development of α‐synuclein immunoreactive aggregates in selectively vulnerable neuronal types of the human central, peripheral, and enteric nervous systems is crucial for the pathogenesis of sporadic Parkinson's disease. The presence of these lesions persists into the end phase of the disea...