Bimodal Expansion of the Lymphatic Vessels Is Regulated by the Sequential Expression of IL-7 and Lymphotoxin α1β2 in Newly Formed Tertiary Lymphoid Structures

• Published in: The Journal of immunology (1950) Vol. 197; no. 5; pp. 1957 - 1967
• Main Authors: Nayar, Saba, Campos, Joana, Chung, Ming May, Navarro-Núñez, Leyre, Chachlani, Menka, Steinthal, Nathalie, Gardner, David H, Rankin, Philip, Cloake, Thomas, Caamaño, Jorge H, McGettrick, Helen M, Watson, Steve P, Luther, Sanjiv, Buckley, Christopher D, Barone, Francesca
• Format: Journal Article
• Language: English
• Published: United States AAI 01.09.2016
• Subjects: Animals; Gene Expression Regulation; Inflammation; Interleukin-7 - genetics; Interleukin-7 - immunology; Interleukin-7 - metabolism; Lymphangiogenesis; Lymphatic Vessels - immunology; Lymphatic Vessels - metabolism; Lymphotoxin alpha1, beta2 Heterotrimer - genetics; Lymphotoxin alpha1, beta2 Heterotrimer - immunology; Lymphotoxin alpha1, beta2 Heterotrimer - metabolism; Mice; Mucosal Immunology; Salivary Glands - immunology; Signal Transduction - genetics; Signal Transduction - immunology; Tertiary Lymphoid Structures - immunology; Tertiary Lymphoid Structures - pathology

Lymphangiogenesis associated with tertiary lymphoid structure (TLS) has been reported in numerous studies. However, the kinetics and dynamic changes occurring to the lymphatic vascular network during TLS development have not been studied. Using a viral-induced, resolving model of TLS formation in th...